Participant characteristics of HNSCC cases and controls
| Characteristics . | Cases, n (%) . | Controls, n (%) . | All HNSCC, OR (95% CI)* . | Oral cavity only, OR (95% CI)† . | Pharynx only, OR (95% CI)‡ . | Larynx only, OR (95% CI)§ . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age (y) | ||||||||||||
| <52 | 143 (27.4) | 141 (23.5) | ||||||||||
| >52-60 | 133 (25.5) | 153 (25.5) | ||||||||||
| >60-68 | 123 (23.6) | 151 (25.2) | ||||||||||
| >68 | 122 (23.4) | 154 (25.7) | ||||||||||
| Gender | ||||||||||||
| Male | 375 (72.0) | 430 (71.8) | ||||||||||
| Female | 146 (28.0) | 169 (28.2) | ||||||||||
| Race | ||||||||||||
| Caucasian | 446 (85.6) | 540 (90.2) | ||||||||||
| Black | 23 (4.4) | 21 (3.5) | ||||||||||
| Other | 50 (9.6) | 37 (6.2) | ||||||||||
| Missing | 2 (0.4) | 1 (0.2) | ||||||||||
| Tobacco (pack-years) | ||||||||||||
| 0 | 100 (19.2) | 198 (33.1) | 1.0 | 1.0 | 1.0 | 1.0 | ||||||
| >0-15 | 77 (14.8) | 129 (21.5) | 1.2 (0.8-1.7) | 1.0 (0.6-1.5) | 1.5 (0.8-2.6) | 1.9 (0.8-4.3) | ||||||
| >15-35 | 92 (17.7) | 118 (19.7) | 1.7 (1.2-2.5) | 1.8 (1.2-2.8) | 1.5 (0.8-2.7) | 2.5 (1.1-5.6) | ||||||
| >35-58 | 107 (20.5) | 94 (15.7) | 2.6 (1.8-3.7) | 2.0 (1.3-3.3) | 2.7 (1.5-4.9) | 5.6 (2.6-12) | ||||||
| >58 | 145 (27.8) | 60 (10.0) | 5.6 (3.8-8.4) | 4.0 (2.5-6.6) | 5.6 (3.1-10) | 14.8 (6.9-32) | ||||||
| Tobacco (pack-years)∥ | ||||||||||||
| None | 100 (19.2) | 198 (33.1) | 1.0 | 1.0 | 1.0 | 1.0 | ||||||
| Light | 169 (32.4) | 247 (41.2) | 1.4 (1.0-1.9) | 1.3 (0.9-2.0) | 1.5 (0.9-2.5) | 2.1 (1.0-4.4) | ||||||
| Heavy | 252 (48.4) | 154 (25.7) | 3.7 (2.6-5.1) | 2.7 (1.8-4.1) | 3.9 (2.3-6.5) | 8.9 (4.4-18) | ||||||
| Alcohol (drinks/wk) | ||||||||||||
| 0 | 81 (15.5) | 108 (18.0) | 1.0 | 1.0 | 1.0 | 1.0 | ||||||
| >0-6 | 90 (17.3) | 190 (31.7) | 0.7 (0.5-1.0) | 0.6 (0.4-1.0) | 0.7 (0.4-1.3) | 0.9 (0.5-1.0) | ||||||
| >6-11 | 74 (14.2) | 113 (18.9) | 1.0 (0.7-1.5) | 1.0 (0.6-1.7) | 1.0 (0.5-2.1) | 1.2 (0.7-1.5) | ||||||
| >11-26 | 119 (22.8) | 117 (19.5) | 1.7 (1.1-2.5) | 1.5 (0.9-2.5) | 1.9 (1.0-3.5) | 2.2 (1.1-2.5) | ||||||
| >26 | 156 (29.9) | 69 (11.5) | 3.7 (2.4-5.7) | 4.0 (2.3-6.7) | 4.5 (2.4-8.4) | 2.9 (2.4-5.7) | ||||||
| Missing | 1 (0.2) | 2 (0.3) | ||||||||||
| Alcohol (drinks/wk)¶ | ||||||||||||
| None | 81 (15.5) | 108 (18.0) | 1.0 | 1.0 | 1.0 | 1.0 | ||||||
| Light | 298 (57.2) | 433 (72.3) | 1.0 (0.7-1.4) | 0.9 (0.6-1.4) | 1.1 (0.6-1.8) | 1.4 (0.7-2.6) | ||||||
| Heavy | 141 (27.1) | 56 (9.3) | 3.8 (2.5-6.0) | 4.2 (2.5-7.2) | 4.9 (2.6-9.3) | 2.6 (1.2-5.8) | ||||||
| Missing | 1 (0.2) | 2 (0.3) | ||||||||||
| ADH1C | ||||||||||||
| 1*1 | 197 (37.8) | 240 (40.1) | 1.0 | 1.0 | 1.0 | 1.0 | ||||||
| 1*2 | 242 (46.4) | 273 (45.6) | 1.1 (0.9-1.4) | 1.2 (0.9-1.7) | 0.8 (0.6-1.2) | 1.3 (0.8-2.1) | ||||||
| 2*2 | 82 (15.7) | 86 (14.4) | 1.2 (0.9-1.8) | 1.1 (0.7-1.7) | 1.0 (0.6-1.8) | 1.9 (1.0-3.5) | ||||||
| Total | 521 | 599 | ||||||||||
| Characteristics . | Cases, n (%) . | Controls, n (%) . | All HNSCC, OR (95% CI)* . | Oral cavity only, OR (95% CI)† . | Pharynx only, OR (95% CI)‡ . | Larynx only, OR (95% CI)§ . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age (y) | ||||||||||||
| <52 | 143 (27.4) | 141 (23.5) | ||||||||||
| >52-60 | 133 (25.5) | 153 (25.5) | ||||||||||
| >60-68 | 123 (23.6) | 151 (25.2) | ||||||||||
| >68 | 122 (23.4) | 154 (25.7) | ||||||||||
| Gender | ||||||||||||
| Male | 375 (72.0) | 430 (71.8) | ||||||||||
| Female | 146 (28.0) | 169 (28.2) | ||||||||||
| Race | ||||||||||||
| Caucasian | 446 (85.6) | 540 (90.2) | ||||||||||
| Black | 23 (4.4) | 21 (3.5) | ||||||||||
| Other | 50 (9.6) | 37 (6.2) | ||||||||||
| Missing | 2 (0.4) | 1 (0.2) | ||||||||||
| Tobacco (pack-years) | ||||||||||||
| 0 | 100 (19.2) | 198 (33.1) | 1.0 | 1.0 | 1.0 | 1.0 | ||||||
| >0-15 | 77 (14.8) | 129 (21.5) | 1.2 (0.8-1.7) | 1.0 (0.6-1.5) | 1.5 (0.8-2.6) | 1.9 (0.8-4.3) | ||||||
| >15-35 | 92 (17.7) | 118 (19.7) | 1.7 (1.2-2.5) | 1.8 (1.2-2.8) | 1.5 (0.8-2.7) | 2.5 (1.1-5.6) | ||||||
| >35-58 | 107 (20.5) | 94 (15.7) | 2.6 (1.8-3.7) | 2.0 (1.3-3.3) | 2.7 (1.5-4.9) | 5.6 (2.6-12) | ||||||
| >58 | 145 (27.8) | 60 (10.0) | 5.6 (3.8-8.4) | 4.0 (2.5-6.6) | 5.6 (3.1-10) | 14.8 (6.9-32) | ||||||
| Tobacco (pack-years)∥ | ||||||||||||
| None | 100 (19.2) | 198 (33.1) | 1.0 | 1.0 | 1.0 | 1.0 | ||||||
| Light | 169 (32.4) | 247 (41.2) | 1.4 (1.0-1.9) | 1.3 (0.9-2.0) | 1.5 (0.9-2.5) | 2.1 (1.0-4.4) | ||||||
| Heavy | 252 (48.4) | 154 (25.7) | 3.7 (2.6-5.1) | 2.7 (1.8-4.1) | 3.9 (2.3-6.5) | 8.9 (4.4-18) | ||||||
| Alcohol (drinks/wk) | ||||||||||||
| 0 | 81 (15.5) | 108 (18.0) | 1.0 | 1.0 | 1.0 | 1.0 | ||||||
| >0-6 | 90 (17.3) | 190 (31.7) | 0.7 (0.5-1.0) | 0.6 (0.4-1.0) | 0.7 (0.4-1.3) | 0.9 (0.5-1.0) | ||||||
| >6-11 | 74 (14.2) | 113 (18.9) | 1.0 (0.7-1.5) | 1.0 (0.6-1.7) | 1.0 (0.5-2.1) | 1.2 (0.7-1.5) | ||||||
| >11-26 | 119 (22.8) | 117 (19.5) | 1.7 (1.1-2.5) | 1.5 (0.9-2.5) | 1.9 (1.0-3.5) | 2.2 (1.1-2.5) | ||||||
| >26 | 156 (29.9) | 69 (11.5) | 3.7 (2.4-5.7) | 4.0 (2.3-6.7) | 4.5 (2.4-8.4) | 2.9 (2.4-5.7) | ||||||
| Missing | 1 (0.2) | 2 (0.3) | ||||||||||
| Alcohol (drinks/wk)¶ | ||||||||||||
| None | 81 (15.5) | 108 (18.0) | 1.0 | 1.0 | 1.0 | 1.0 | ||||||
| Light | 298 (57.2) | 433 (72.3) | 1.0 (0.7-1.4) | 0.9 (0.6-1.4) | 1.1 (0.6-1.8) | 1.4 (0.7-2.6) | ||||||
| Heavy | 141 (27.1) | 56 (9.3) | 3.8 (2.5-6.0) | 4.2 (2.5-7.2) | 4.9 (2.6-9.3) | 2.6 (1.2-5.8) | ||||||
| Missing | 1 (0.2) | 2 (0.3) | ||||||||||
| ADH1C | ||||||||||||
| 1*1 | 197 (37.8) | 240 (40.1) | 1.0 | 1.0 | 1.0 | 1.0 | ||||||
| 1*2 | 242 (46.4) | 273 (45.6) | 1.1 (0.9-1.4) | 1.2 (0.9-1.7) | 0.8 (0.6-1.2) | 1.3 (0.8-2.1) | ||||||
| 2*2 | 82 (15.7) | 86 (14.4) | 1.2 (0.9-1.8) | 1.1 (0.7-1.7) | 1.0 (0.6-1.8) | 1.9 (1.0-3.5) | ||||||
| Total | 521 | 599 | ||||||||||
All HNSCC (521 cases), adjusted for age, gender, and race.
Oral cavity (256 cases, includes ICD-9 codes 140, 141 143, 144, and 145), adjusted for age, gender, and race.
Pharynx (149 cases, includes ICD-9 codes 146, 148, and 149), adjusted for age, gender, and race.
Larynx (106 cases, includes ICD-9 code 161), adjusted for age, gender, and race.
Cutpoint for heavy tobacco is 35 pack-years.
Cutpoint for heavy alcohol is 30 per week.