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Table 1

Basal cell carcinoma and breast cancer risk in relation to XRCC3 codon 241 polymorphisms

The genotype distribution was in Hardy-Weinberg equilibrium for all control groups. The odds ratios for the basal cell carcinoma and the breast cancer groups are based on information from known discordant pairs only, due to matched design.

GenotypeBasal cell carcinomaBreast cancer
CasesControlsOR (95% CI)aCasesControlsOR (95% CI)a
CC (Thr/Thr) 129 146 1.0b 163 160 1.0b 
CT (Thr/Met) 158 129 1.46 (1.04–2.05) 203 198 1.01 (0.75–1.35) 
TT (Met/Met) 31 43 0.86 (0.52–1.43) 59 65 0.89 (0.59–1.35) 
Missing   
Allele frequencyc 0.346 0.338  0.378 0.388  
GenotypeBasal cell carcinomaBreast cancer
CasesControlsOR (95% CI)aCasesControlsOR (95% CI)a
CC (Thr/Thr) 129 146 1.0b 163 160 1.0b 
CT (Thr/Met) 158 129 1.46 (1.04–2.05) 203 198 1.01 (0.75–1.35) 
TT (Met/Met) 31 43 0.86 (0.52–1.43) 59 65 0.89 (0.59–1.35) 
Missing   
Allele frequencyc 0.346 0.338  0.378 0.388  
a

OR, odds ratio; CI, confidence interval.

b

The CC genotype (Thr/Thr) served as reference category.

c

Allele frequency of the T allele.

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