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Table 5.

Postmenopausal obesity and breast cancer risk stratified by hormone receptor expression

First author (reference)Country (study)Cases (n)BMI (kg/m2)*
Risk estimate (95% CI)
Reference groupBMI category
     ER+ ER− 
Sellers (15) United States (IWHS) 1,355 <22.90 22.90-25.04 1.3 (1.0-1.6) 1.4 (0.8-2.2) 
    25.05-27.43 1.4 (1.1-1.7) 1.4 (0.9-2.3) 
    27.44-30.69 1.8 (1.4-2.2) 2.0 (1.2-3.2) 
    30.70+ 2.0 (1.6-2.5) 1.4 (0.8-2.4) 
Yoo (40) Japan 455 Continuous Per 1 kg/m2 1.09 (1.05-1.13) 1.05 (0.99-1.12) 
     PR+ PR− 
Sellers (15) United States (IWHS) 1,355 <22.90 22.90-25.04 1.3 (1.0-1.7) 1.1 (0.8-1.6) 
    25.05-27.43 1.5 (1.2-1.9) 1.0 (0.7-1.5) 
    27.44-30.69 2.0 (1.6-2.5) 1.5 (1.0-2.1) 
    30.70+ 2.2 (1.7-2.9) 1.0 (0.6-1.5) 
Yoo (40) Japan 455 Continuous Per 1 kg/m2 1.09 (1.04-1.14) 1.07 (1.02-1.11) 
     ER+/PR+ ER−/PR− 
Enger (30) United States (LA County) 760 <21.7 21.7-23.6 1.4 (1.0-1.9) 1.2 (0.7-2.0) 
    23.7-27.0 1.8 (1.3-2.5) 0.8 (0.5-1.4) 
    27.1+ 2.5 (1.7-3.5) 1.2 (0.7-2.1) 
Huang (32) United States (CBCS) 783 <23 23-31 1.1 (0.7-1.8) 1.0 (0.6-1.9) 
    31+ 1.6 (0.9-3.0) 0.8 (0.4-1.7) 
Cotterchio (24) Canada (ON) 1,867 20-25 <20 0.7 (0.4-1.2) 1.3 (0.7-2.5) 
    25.1-27 1.1 (0.8-1.4) 1.1 (0.7-1.6) 
    27.1+ 1.6 (1.3-2.0) 1.5 (1.1-2.0) 
Potter (17) United States (IWHS) 610 <30 30+ 1.5 (1.1-1.9) 0.8 (0.8-2.8) 
First author (reference)Country (study)Cases (n)BMI (kg/m2)*
Risk estimate (95% CI)
Reference groupBMI category
     ER+ ER− 
Sellers (15) United States (IWHS) 1,355 <22.90 22.90-25.04 1.3 (1.0-1.6) 1.4 (0.8-2.2) 
    25.05-27.43 1.4 (1.1-1.7) 1.4 (0.9-2.3) 
    27.44-30.69 1.8 (1.4-2.2) 2.0 (1.2-3.2) 
    30.70+ 2.0 (1.6-2.5) 1.4 (0.8-2.4) 
Yoo (40) Japan 455 Continuous Per 1 kg/m2 1.09 (1.05-1.13) 1.05 (0.99-1.12) 
     PR+ PR− 
Sellers (15) United States (IWHS) 1,355 <22.90 22.90-25.04 1.3 (1.0-1.7) 1.1 (0.8-1.6) 
    25.05-27.43 1.5 (1.2-1.9) 1.0 (0.7-1.5) 
    27.44-30.69 2.0 (1.6-2.5) 1.5 (1.0-2.1) 
    30.70+ 2.2 (1.7-2.9) 1.0 (0.6-1.5) 
Yoo (40) Japan 455 Continuous Per 1 kg/m2 1.09 (1.04-1.14) 1.07 (1.02-1.11) 
     ER+/PR+ ER−/PR− 
Enger (30) United States (LA County) 760 <21.7 21.7-23.6 1.4 (1.0-1.9) 1.2 (0.7-2.0) 
    23.7-27.0 1.8 (1.3-2.5) 0.8 (0.5-1.4) 
    27.1+ 2.5 (1.7-3.5) 1.2 (0.7-2.1) 
Huang (32) United States (CBCS) 783 <23 23-31 1.1 (0.7-1.8) 1.0 (0.6-1.9) 
    31+ 1.6 (0.9-3.0) 0.8 (0.4-1.7) 
Cotterchio (24) Canada (ON) 1,867 20-25 <20 0.7 (0.4-1.2) 1.3 (0.7-2.5) 
    25.1-27 1.1 (0.8-1.4) 1.1 (0.7-1.6) 
    27.1+ 1.6 (1.3-2.0) 1.5 (1.1-2.0) 
Potter (17) United States (IWHS) 610 <30 30+ 1.5 (1.1-1.9) 0.8 (0.8-2.8) 
*

Current or baseline BMI (kg/m2), except for Enger et al. and Huang et al., who report BMI 1 year prior to interview.

ORs were the reported risk estimates for case-control studies and RRs for cohort designs.

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