Postmenopausal obesity and breast cancer risk stratified by hormone receptor expression
| First author (reference) . | Country (study) . | Cases (n) . | BMI (kg/m2)* . | . | Risk estimate (95% CI)† . | . | ||
|---|---|---|---|---|---|---|---|---|
| . | . | . | Reference group . | BMI category . | . | . | ||
| ER+ | ER− | |||||||
| Sellers (15) | United States (IWHS) | 1,355 | <22.90 | 22.90-25.04 | 1.3 (1.0-1.6) | 1.4 (0.8-2.2) | ||
| 25.05-27.43 | 1.4 (1.1-1.7) | 1.4 (0.9-2.3) | ||||||
| 27.44-30.69 | 1.8 (1.4-2.2) | 2.0 (1.2-3.2) | ||||||
| 30.70+ | 2.0 (1.6-2.5) | 1.4 (0.8-2.4) | ||||||
| Yoo (40) | Japan | 455 | Continuous | Per 1 kg/m2 | 1.09 (1.05-1.13) | 1.05 (0.99-1.12) | ||
| PR+ | PR− | |||||||
| Sellers (15) | United States (IWHS) | 1,355 | <22.90 | 22.90-25.04 | 1.3 (1.0-1.7) | 1.1 (0.8-1.6) | ||
| 25.05-27.43 | 1.5 (1.2-1.9) | 1.0 (0.7-1.5) | ||||||
| 27.44-30.69 | 2.0 (1.6-2.5) | 1.5 (1.0-2.1) | ||||||
| 30.70+ | 2.2 (1.7-2.9) | 1.0 (0.6-1.5) | ||||||
| Yoo (40) | Japan | 455 | Continuous | Per 1 kg/m2 | 1.09 (1.04-1.14) | 1.07 (1.02-1.11) | ||
| ER+/PR+ | ER−/PR− | |||||||
| Enger (30) | United States (LA County) | 760 | <21.7 | 21.7-23.6 | 1.4 (1.0-1.9) | 1.2 (0.7-2.0) | ||
| 23.7-27.0 | 1.8 (1.3-2.5) | 0.8 (0.5-1.4) | ||||||
| 27.1+ | 2.5 (1.7-3.5) | 1.2 (0.7-2.1) | ||||||
| Huang (32) | United States (CBCS) | 783 | <23 | 23-31 | 1.1 (0.7-1.8) | 1.0 (0.6-1.9) | ||
| 31+ | 1.6 (0.9-3.0) | 0.8 (0.4-1.7) | ||||||
| Cotterchio (24) | Canada (ON) | 1,867 | 20-25 | <20 | 0.7 (0.4-1.2) | 1.3 (0.7-2.5) | ||
| 25.1-27 | 1.1 (0.8-1.4) | 1.1 (0.7-1.6) | ||||||
| 27.1+ | 1.6 (1.3-2.0) | 1.5 (1.1-2.0) | ||||||
| Potter (17) | United States (IWHS) | 610 | <30 | 30+ | 1.5 (1.1-1.9) | 0.8 (0.8-2.8) | ||
| First author (reference) . | Country (study) . | Cases (n) . | BMI (kg/m2)* . | . | Risk estimate (95% CI)† . | . | ||
|---|---|---|---|---|---|---|---|---|
| . | . | . | Reference group . | BMI category . | . | . | ||
| ER+ | ER− | |||||||
| Sellers (15) | United States (IWHS) | 1,355 | <22.90 | 22.90-25.04 | 1.3 (1.0-1.6) | 1.4 (0.8-2.2) | ||
| 25.05-27.43 | 1.4 (1.1-1.7) | 1.4 (0.9-2.3) | ||||||
| 27.44-30.69 | 1.8 (1.4-2.2) | 2.0 (1.2-3.2) | ||||||
| 30.70+ | 2.0 (1.6-2.5) | 1.4 (0.8-2.4) | ||||||
| Yoo (40) | Japan | 455 | Continuous | Per 1 kg/m2 | 1.09 (1.05-1.13) | 1.05 (0.99-1.12) | ||
| PR+ | PR− | |||||||
| Sellers (15) | United States (IWHS) | 1,355 | <22.90 | 22.90-25.04 | 1.3 (1.0-1.7) | 1.1 (0.8-1.6) | ||
| 25.05-27.43 | 1.5 (1.2-1.9) | 1.0 (0.7-1.5) | ||||||
| 27.44-30.69 | 2.0 (1.6-2.5) | 1.5 (1.0-2.1) | ||||||
| 30.70+ | 2.2 (1.7-2.9) | 1.0 (0.6-1.5) | ||||||
| Yoo (40) | Japan | 455 | Continuous | Per 1 kg/m2 | 1.09 (1.04-1.14) | 1.07 (1.02-1.11) | ||
| ER+/PR+ | ER−/PR− | |||||||
| Enger (30) | United States (LA County) | 760 | <21.7 | 21.7-23.6 | 1.4 (1.0-1.9) | 1.2 (0.7-2.0) | ||
| 23.7-27.0 | 1.8 (1.3-2.5) | 0.8 (0.5-1.4) | ||||||
| 27.1+ | 2.5 (1.7-3.5) | 1.2 (0.7-2.1) | ||||||
| Huang (32) | United States (CBCS) | 783 | <23 | 23-31 | 1.1 (0.7-1.8) | 1.0 (0.6-1.9) | ||
| 31+ | 1.6 (0.9-3.0) | 0.8 (0.4-1.7) | ||||||
| Cotterchio (24) | Canada (ON) | 1,867 | 20-25 | <20 | 0.7 (0.4-1.2) | 1.3 (0.7-2.5) | ||
| 25.1-27 | 1.1 (0.8-1.4) | 1.1 (0.7-1.6) | ||||||
| 27.1+ | 1.6 (1.3-2.0) | 1.5 (1.1-2.0) | ||||||
| Potter (17) | United States (IWHS) | 610 | <30 | 30+ | 1.5 (1.1-1.9) | 0.8 (0.8-2.8) | ||