American Association for Cancer Research

Table 3

Stratified analyses of MPO polymorphism and lung cancer in selected subgroups^a

		Crude OR					Adjusted OR^b
				A/A vs. G/G	A/G vs. G/G	A/A + A/G vs. G/G	A/A vs. G/G	A/G vs. G/G	A/A + A/G vs. G/G
Age ≤ 59^c		1.22 (0.6–2.4)	0.92 (0.7–1.3)	0.96 (0.7–1.3)	1.14 (0.5–2.4)	0.85 (0.6–1.2)	0.88 (0.6–1.2)
Cases	n = 282	16/171^d	95/171^e	111/171^f
Controls	n = 549	25/327	197/327	222/327
Age > 59		1.68 (0.9–3.1)	1.11 (0.9–1.4)	1.16 (0.9–1.5)	1.10 (0.5–2.2)	1.10 (0.8–1.5)	1.10 (0.8–1.4)
Cases	n = 706	31/427	248/427	279/427
Controls	n = 579	16/370	193/370	209/370
Females		1.27 (0.7–2.4)	0.97 (0.7–1.3)	0.99 (0.8–1.3)	1.29 (0.6–2.8)	0.99 (0.7–1.4)	1.01 (0.7–1.4)
Cases	n = 450	20/273	157/273	177/273
Controls	n = 603	21/365	217/365	238/365
Males		1.38 (0.8–2.5)	1.10 (0.8–1.4)	1.13 (0.9–1.4)	1.08 (0.5–2.2)	1.05 (0.8–1.4)	1.05 (0.8–1.4)
Cases	n = 538	27/325	186/325	213/325
Controls	n = 525	20/332	173/332	193/325
Current smokers		2.19 (0.9–5.2)	1.16 (0.8–1.7)	1.25 (0.9–1.8)	2.38 (0.9–6.2)	1.25 (0.8–1.9)	1.34 (0.9–2.0)
Cases	n = 406	26/234	146/234	172/234
Controls	n = 219	7/138	74/138	81/138
Former smokers		0.80 (0.4–1.5)	1.01 (0.8–1.3)	0.98 (0.8–1.3)	0.72 (0.4–1.5)	0.95 (0.7–1.3)	0.92 (0.7–1.2)
Cases	n = 519	19/322	178/322	197/322
Controls	n = 506	23/312	171/312	194/312
Nonsmokers		n/a	0.77 (0.4–1.4)	0.79 (0.5–1.4)	n/a	0.79 (0.4–1.4)	0.82 (0.5–1.4)
Cases	n = 63	2/42	19/42	21/42
Controls	n = 403	11/247	145/247	156/247
Adenocarcinomas		1.39 (0.8–2.4)	1.06 (0.8–1.3)	1.09 (0.9–1.4)	1.36 (0.8–2.5)	1.03 (0.8–1.3)	1.06 (0.8–1.4)
Cases	n = 473	23/283	167/283	190/283
Controls	n = 1128	41/697	390/697	431/697
Squamous cell carcinoma		2.02 (1.1–3.8)^d	1.19 (0.9–1.6)	1.27 (0.95–1.7)	1.82 (0.8–4.1)	1.33 (0.9–1.9)	1.38 (0.96–2.0)
Cases	n = 225	15/126	84/126	99/126
Controls	n = 1128	41/697	390/697	431/697

		Crude OR					Adjusted OR^b
				A/A vs. G/G	A/G vs. G/G	A/A + A/G vs. G/G	A/A vs. G/G	A/G vs. G/G	A/A + A/G vs. G/G
Age ≤ 59^c		1.22 (0.6–2.4)	0.92 (0.7–1.3)	0.96 (0.7–1.3)	1.14 (0.5–2.4)	0.85 (0.6–1.2)	0.88 (0.6–1.2)
Cases	n = 282	16/171^d	95/171^e	111/171^f
Controls	n = 549	25/327	197/327	222/327
Age > 59		1.68 (0.9–3.1)	1.11 (0.9–1.4)	1.16 (0.9–1.5)	1.10 (0.5–2.2)	1.10 (0.8–1.5)	1.10 (0.8–1.4)
Cases	n = 706	31/427	248/427	279/427
Controls	n = 579	16/370	193/370	209/370
Females		1.27 (0.7–2.4)	0.97 (0.7–1.3)	0.99 (0.8–1.3)	1.29 (0.6–2.8)	0.99 (0.7–1.4)	1.01 (0.7–1.4)
Cases	n = 450	20/273	157/273	177/273
Controls	n = 603	21/365	217/365	238/365
Males		1.38 (0.8–2.5)	1.10 (0.8–1.4)	1.13 (0.9–1.4)	1.08 (0.5–2.2)	1.05 (0.8–1.4)	1.05 (0.8–1.4)
Cases	n = 538	27/325	186/325	213/325
Controls	n = 525	20/332	173/332	193/325
Current smokers		2.19 (0.9–5.2)	1.16 (0.8–1.7)	1.25 (0.9–1.8)	2.38 (0.9–6.2)	1.25 (0.8–1.9)	1.34 (0.9–2.0)
Cases	n = 406	26/234	146/234	172/234
Controls	n = 219	7/138	74/138	81/138
Former smokers		0.80 (0.4–1.5)	1.01 (0.8–1.3)	0.98 (0.8–1.3)	0.72 (0.4–1.5)	0.95 (0.7–1.3)	0.92 (0.7–1.2)
Cases	n = 519	19/322	178/322	197/322
Controls	n = 506	23/312	171/312	194/312
Nonsmokers		n/a	0.77 (0.4–1.4)	0.79 (0.5–1.4)	n/a	0.79 (0.4–1.4)	0.82 (0.5–1.4)
Cases	n = 63	2/42	19/42	21/42
Controls	n = 403	11/247	145/247	156/247
Adenocarcinomas		1.39 (0.8–2.4)	1.06 (0.8–1.3)	1.09 (0.9–1.4)	1.36 (0.8–2.5)	1.03 (0.8–1.3)	1.06 (0.8–1.4)
Cases	n = 473	23/283	167/283	190/283
Controls	n = 1128	41/697	390/697	431/697
Squamous cell carcinoma		2.02 (1.1–3.8)^d	1.19 (0.9–1.6)	1.27 (0.95–1.7)	1.82 (0.8–4.1)	1.33 (0.9–1.9)	1.38 (0.96–2.0)
Cases	n = 225	15/126	84/126	99/126
Controls	n = 1128	41/697	390/697	431/697

P > 0.05 unless otherwise indicated. n/a, numbers in at least one category or “cells” were too small (<10) for appropriate analysis.

Adjusted analyses include covariates for age, gender, SR-PY, smoking status, and time since smoking cessation.

Median age of controls.

Number of A/A/number of G/G.

Number of A/G/number of G/G.

Number of A/A + A/G/number of G/G.

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