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Table 3

Stratified analyses of MPO polymorphism and lung cancer in selected subgroupsa

Crude ORAdjusted ORb
A/A vs. G/GA/G vs. G/GA/A + A/G vs. G/GA/A vs. G/GA/G vs. G/GA/A + A/G vs. G/G
Age ≤ 59c  1.22 (0.6–2.4) 0.92 (0.7–1.3) 0.96 (0.7–1.3) 1.14 (0.5–2.4) 0.85 (0.6–1.2) 0.88 (0.6–1.2) 
 Cases n = 282 16/171d 95/171e 111/171f    
 Controls n = 549 25/327 197/327 222/327    
Age > 59  1.68 (0.9–3.1) 1.11 (0.9–1.4) 1.16 (0.9–1.5) 1.10 (0.5–2.2) 1.10 (0.8–1.5) 1.10 (0.8–1.4) 
 Cases n = 706 31/427 248/427 279/427    
 Controls n = 579 16/370 193/370 209/370    
Females  1.27 (0.7–2.4) 0.97 (0.7–1.3) 0.99 (0.8–1.3) 1.29 (0.6–2.8) 0.99 (0.7–1.4) 1.01 (0.7–1.4) 
 Cases n = 450 20/273 157/273 177/273    
 Controls n = 603 21/365 217/365 238/365    
Males  1.38 (0.8–2.5) 1.10 (0.8–1.4) 1.13 (0.9–1.4) 1.08 (0.5–2.2) 1.05 (0.8–1.4) 1.05 (0.8–1.4) 
 Cases n = 538 27/325 186/325 213/325    
 Controls n = 525 20/332 173/332 193/325    
Current smokers  2.19 (0.9–5.2) 1.16 (0.8–1.7) 1.25 (0.9–1.8) 2.38 (0.9–6.2) 1.25 (0.8–1.9) 1.34 (0.9–2.0) 
 Cases n = 406 26/234 146/234 172/234    
 Controls n = 219 7/138 74/138 81/138    
Former smokers  0.80 (0.4–1.5) 1.01 (0.8–1.3) 0.98 (0.8–1.3) 0.72 (0.4–1.5) 0.95 (0.7–1.3) 0.92 (0.7–1.2) 
 Cases n = 519 19/322 178/322 197/322    
 Controls n = 506 23/312 171/312 194/312    
Nonsmokers  n/a 0.77 (0.4–1.4) 0.79 (0.5–1.4) n/a 0.79 (0.4–1.4) 0.82 (0.5–1.4) 
 Cases n = 63 2/42 19/42 21/42    
 Controls n = 403 11/247 145/247 156/247    
Adenocarcinomas  1.39 (0.8–2.4) 1.06 (0.8–1.3) 1.09 (0.9–1.4) 1.36 (0.8–2.5) 1.03 (0.8–1.3) 1.06 (0.8–1.4) 
 Cases n = 473 23/283 167/283 190/283    
 Controls n = 1128 41/697 390/697 431/697    
Squamous cell carcinoma  2.02 (1.1–3.8)d 1.19 (0.9–1.6) 1.27 (0.95–1.7) 1.82 (0.8–4.1) 1.33 (0.9–1.9) 1.38 (0.96–2.0) 
 Cases n = 225 15/126 84/126 99/126    
 Controls n = 1128 41/697 390/697 431/697    
Crude ORAdjusted ORb
A/A vs. G/GA/G vs. G/GA/A + A/G vs. G/GA/A vs. G/GA/G vs. G/GA/A + A/G vs. G/G
Age ≤ 59c  1.22 (0.6–2.4) 0.92 (0.7–1.3) 0.96 (0.7–1.3) 1.14 (0.5–2.4) 0.85 (0.6–1.2) 0.88 (0.6–1.2) 
 Cases n = 282 16/171d 95/171e 111/171f    
 Controls n = 549 25/327 197/327 222/327    
Age > 59  1.68 (0.9–3.1) 1.11 (0.9–1.4) 1.16 (0.9–1.5) 1.10 (0.5–2.2) 1.10 (0.8–1.5) 1.10 (0.8–1.4) 
 Cases n = 706 31/427 248/427 279/427    
 Controls n = 579 16/370 193/370 209/370    
Females  1.27 (0.7–2.4) 0.97 (0.7–1.3) 0.99 (0.8–1.3) 1.29 (0.6–2.8) 0.99 (0.7–1.4) 1.01 (0.7–1.4) 
 Cases n = 450 20/273 157/273 177/273    
 Controls n = 603 21/365 217/365 238/365    
Males  1.38 (0.8–2.5) 1.10 (0.8–1.4) 1.13 (0.9–1.4) 1.08 (0.5–2.2) 1.05 (0.8–1.4) 1.05 (0.8–1.4) 
 Cases n = 538 27/325 186/325 213/325    
 Controls n = 525 20/332 173/332 193/325    
Current smokers  2.19 (0.9–5.2) 1.16 (0.8–1.7) 1.25 (0.9–1.8) 2.38 (0.9–6.2) 1.25 (0.8–1.9) 1.34 (0.9–2.0) 
 Cases n = 406 26/234 146/234 172/234    
 Controls n = 219 7/138 74/138 81/138    
Former smokers  0.80 (0.4–1.5) 1.01 (0.8–1.3) 0.98 (0.8–1.3) 0.72 (0.4–1.5) 0.95 (0.7–1.3) 0.92 (0.7–1.2) 
 Cases n = 519 19/322 178/322 197/322    
 Controls n = 506 23/312 171/312 194/312    
Nonsmokers  n/a 0.77 (0.4–1.4) 0.79 (0.5–1.4) n/a 0.79 (0.4–1.4) 0.82 (0.5–1.4) 
 Cases n = 63 2/42 19/42 21/42    
 Controls n = 403 11/247 145/247 156/247    
Adenocarcinomas  1.39 (0.8–2.4) 1.06 (0.8–1.3) 1.09 (0.9–1.4) 1.36 (0.8–2.5) 1.03 (0.8–1.3) 1.06 (0.8–1.4) 
 Cases n = 473 23/283 167/283 190/283    
 Controls n = 1128 41/697 390/697 431/697    
Squamous cell carcinoma  2.02 (1.1–3.8)d 1.19 (0.9–1.6) 1.27 (0.95–1.7) 1.82 (0.8–4.1) 1.33 (0.9–1.9) 1.38 (0.96–2.0) 
 Cases n = 225 15/126 84/126 99/126    
 Controls n = 1128 41/697 390/697 431/697    
a

P > 0.05 unless otherwise indicated. n/a, numbers in at least one category or “cells” were too small (<10) for appropriate analysis.

b

Adjusted analyses include covariates for age, gender, SR-PY, smoking status, and time since smoking cessation.

c

Median age of controls.

d

Number of A/A/number of G/G.

e

Number of A/G/number of G/G.

f

Number of A/A + A/G/number of G/G.

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