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Table 2

Genotype lung cancer association in caucasians

G/GA/GA/AA/G + A/A
n (%)     
 Cases 599 (61%) 343 (35%) 47 (5%) 390 (39%) 
 Controls 697 (62%) 390 (35%) 41 (4%) 431 (38%) 
  Spouse controls 222 (63%) 119 (33%) 13 (4%) 132 (37%) 
  Friend controls 467 (61%) 268 (35%) 28 (4%) 296 (39%) 
OR (95% CI)     
 All controls     
  Crude OR 1.0a 1.03 (0.9–1.2) 1.34 (0.9–2.1) 1.06 (0.9–1.3) 
  OR adjusted for age and gender 1.0 1.02 (0.8–1.2) 1.43 (0.9–2.2) 1.06 (0.9–1.3) 
  OR adjusted for age, gender, smoking variablesb 1.0 1.01 (0.8–1.3) 1.15 (0.7–1.9) 1.03 (0.8–1.3) 
 Spouse control     
  Crude OR 1.0 1.08 (0.8–1.4) 1.25 (0.7–2.3) 1.09 (0.9–1.4) 
  OR adjusted for age and gender 1.0 1.06 (0.8–1.4) 1.26 (0.7–2.4) 1.08 (0.8–1.4) 
  OR adjusted for age, gender, smoking variables 1.0 1.04 (0.8–1.4) 1.08 (0.5–2.1) 1.04 (0.8–1.4) 
 Friend controls     
  Crude OR 1.0 1.00 (0.8–1.2) 1.31 (0.8–2.1) 1.03 (0.8–1.2) 
  OR adjusted for age and gender 1.0 1.01 (0.8–1.2) 1.46 (0.9–2.4) 1.05 (0.9–1.3) 
  OR adjusted for age, gender, smoking variables 1.0 0.95 (0.7–1.2) 1.10 (0.6–2.0) 0.97 (0.8–1.2) 
G/GA/GA/AA/G + A/A
n (%)     
 Cases 599 (61%) 343 (35%) 47 (5%) 390 (39%) 
 Controls 697 (62%) 390 (35%) 41 (4%) 431 (38%) 
  Spouse controls 222 (63%) 119 (33%) 13 (4%) 132 (37%) 
  Friend controls 467 (61%) 268 (35%) 28 (4%) 296 (39%) 
OR (95% CI)     
 All controls     
  Crude OR 1.0a 1.03 (0.9–1.2) 1.34 (0.9–2.1) 1.06 (0.9–1.3) 
  OR adjusted for age and gender 1.0 1.02 (0.8–1.2) 1.43 (0.9–2.2) 1.06 (0.9–1.3) 
  OR adjusted for age, gender, smoking variablesb 1.0 1.01 (0.8–1.3) 1.15 (0.7–1.9) 1.03 (0.8–1.3) 
 Spouse control     
  Crude OR 1.0 1.08 (0.8–1.4) 1.25 (0.7–2.3) 1.09 (0.9–1.4) 
  OR adjusted for age and gender 1.0 1.06 (0.8–1.4) 1.26 (0.7–2.4) 1.08 (0.8–1.4) 
  OR adjusted for age, gender, smoking variables 1.0 1.04 (0.8–1.4) 1.08 (0.5–2.1) 1.04 (0.8–1.4) 
 Friend controls     
  Crude OR 1.0 1.00 (0.8–1.2) 1.31 (0.8–2.1) 1.03 (0.8–1.2) 
  OR adjusted for age and gender 1.0 1.01 (0.8–1.2) 1.46 (0.9–2.4) 1.05 (0.9–1.3) 
  OR adjusted for age, gender, smoking variables 1.0 0.95 (0.7–1.2) 1.10 (0.6–2.0) 0.97 (0.8–1.2) 
a

Reference group.

b

Smoking variables include smoking status, pack-years, and years since smoking cessation for ex-smokers.

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