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Table 3

Association of SHBG with age, ethnicity, BMI, and waist circumference; regression coefficients (β)a from Generalized Estimating Equations

VariableModel 1bModel 2bModel 3b
β (nmol/liter)Pβ (nmol/liter)Pβ (nmol/liter)P
Visit age, per yr 0.3103 0.011 0.3775 0.0011 0.4364 0.0002 
Black race −0.0864 0.90 0.8727 0.19 −0.1655 0.81 
Year 2 BMI, per 1 kg/m2   −0.9082 <0.0001 −0.1452 0.41 
Δ BMI, per 1 kg/m2   −1.4084 <0.0001 −1.1407 <0.0001 
Year 2 waist circumference, per 1 cm     −0.3567 <0.0001 
Δ Waist circumference, per 1 cm     −0.1091 0.17 
VariableModel 1bModel 2bModel 3b
β (nmol/liter)Pβ (nmol/liter)Pβ (nmol/liter)P
Visit age, per yr 0.3103 0.011 0.3775 0.0011 0.4364 0.0002 
Black race −0.0864 0.90 0.8727 0.19 −0.1655 0.81 
Year 2 BMI, per 1 kg/m2   −0.9082 <0.0001 −0.1452 0.41 
Δ BMI, per 1 kg/m2   −1.4084 <0.0001 −1.1407 <0.0001 
Year 2 waist circumference, per 1 cm     −0.3567 <0.0001 
Δ Waist circumference, per 1 cm     −0.1091 0.17 
a

Mean change in SHBG corresponding to the indicated difference in the independent variable.

b

Each of the models also included terms for secular changes in hormone levels between the Years 2 and 7, and the Years 2 and 10 examinations.

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