American Association for Cancer Research

Table 3

Association of SHBG with age, ethnicity, BMI, and waist circumference; regression coefficients (β)^a from Generalized Estimating Equations

Variable	Model 1^b			Model 2^b			Model 3^b
Variable		β (nmol/liter)	P	β (nmol/liter)	P	β (nmol/liter)	P
Visit age, per yr	0.3103	0.011	0.3775	0.0011	0.4364	0.0002
Black race	−0.0864	0.90	0.8727	0.19	−0.1655	0.81
Year 2 BMI, per 1 kg/m²			−0.9082	<0.0001	−0.1452	0.41
Δ BMI, per 1 kg/m²			−1.4084	<0.0001	−1.1407	<0.0001
Year 2 waist circumference, per 1 cm					−0.3567	<0.0001
Δ Waist circumference, per 1 cm					−0.1091	0.17

Variable	Model 1^b			Model 2^b			Model 3^b
Variable		β (nmol/liter)	P	β (nmol/liter)	P	β (nmol/liter)	P
Visit age, per yr	0.3103	0.011	0.3775	0.0011	0.4364	0.0002
Black race	−0.0864	0.90	0.8727	0.19	−0.1655	0.81
Year 2 BMI, per 1 kg/m²			−0.9082	<0.0001	−0.1452	0.41
Δ BMI, per 1 kg/m²			−1.4084	<0.0001	−1.1407	<0.0001
Year 2 waist circumference, per 1 cm					−0.3567	<0.0001
Δ Waist circumference, per 1 cm					−0.1091	0.17

Mean change in SHBG corresponding to the indicated difference in the independent variable.

Each of the models also included terms for secular changes in hormone levels between the Years 2 and 7, and the Years 2 and 10 examinations.