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Table 3

RR of breast cancer in women according to adult weight change: NHEFS

Adult weight change (kg)Person-years of observationNo. of casesMultivariate-adjusted RR (95% CI)a
All women    
 Lost 5.0+ 2,589 12 2.91 (1.41–5.99) 
 Lost/gained 4.9 14,320 28 1 (referent
 Gained 5.0–9.9 9,662 20 1.00 (0.56–1.77) 
 Gained 10.0–19.9 13,193 42 1.53 (0.94–2.48) 
 Gained 20+ 9,253 33 1.72 (0.94–2.89) 
P for trendb   0.275/0.015 
Women <50 yrs of age    
 Lost 5.0+ 899 1.63 (0.20–13.38) 
 Lost/gained 4.9 7,544 12 1.0 
 Gained 5.0–9.9 4,878 0.87 (0.34–2.21) 
 Gained 10.0–19.9 5,409 13 1.62 (0.72–3.60) 
 Gained 20+ 3,428 1.88 (0.73–4.88) 
P for trendb   0.151/0.116 
Women ≥50 yrs of age    
 Lost 5.0+ 1,690 11 3.26 (1.44–7.38) 
 Lost/gained 4.9 6,776 16 1.0 
 Gained 5.0–9.9 4,784 13 1.08 (0.52–2.26) 
 Gained 10.0–19.9 7,784 29 1.56 (0.84–2.90) 
 Gained 20+ 5,824 25 1.74 (0.91–3.30) 
P for trendb   0.568/0.054 
Adult weight change (kg)Person-years of observationNo. of casesMultivariate-adjusted RR (95% CI)a
All women    
 Lost 5.0+ 2,589 12 2.91 (1.41–5.99) 
 Lost/gained 4.9 14,320 28 1 (referent
 Gained 5.0–9.9 9,662 20 1.00 (0.56–1.77) 
 Gained 10.0–19.9 13,193 42 1.53 (0.94–2.48) 
 Gained 20+ 9,253 33 1.72 (0.94–2.89) 
P for trendb   0.275/0.015 
Women <50 yrs of age    
 Lost 5.0+ 899 1.63 (0.20–13.38) 
 Lost/gained 4.9 7,544 12 1.0 
 Gained 5.0–9.9 4,878 0.87 (0.34–2.21) 
 Gained 10.0–19.9 5,409 13 1.62 (0.72–3.60) 
 Gained 20+ 3,428 1.88 (0.73–4.88) 
P for trendb   0.151/0.116 
Women ≥50 yrs of age    
 Lost 5.0+ 1,690 11 3.26 (1.44–7.38) 
 Lost/gained 4.9 6,776 16 1.0 
 Gained 5.0–9.9 4,784 13 1.08 (0.52–2.26) 
 Gained 10.0–19.9 7,784 29 1.56 (0.84–2.90) 
 Gained 20+ 5,824 25 1.74 (0.91–3.30) 
P for trendb   0.568/0.054 
a

Models were adjusted for height, BMI at age 25 years, physical activity in 1982–1984 + 1971–1975, and sample design variables.

b

Tests of trend were performed including/excluding women who lost ≥5 kg.

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