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Table 5.

Proportion of phenotypic variance attributable to additive genetic (A), shared environmental (C), and non-shared environmental influences (E) for the best fitting models for three HR phenotypes during or following 30-min infusion of nicotine

HR phenotypeSource of variation
A (95% CI)C (95% CI)E (95% CI)
All participants (npairs, MZ = 110, DZ = 29)    
    Percent change (0-5 min) — — 100 
    Acceleration (0-30 min)* 30.3 (0, 46.3) 0 (0, 0) 69.7 (53.7, 87.8) 
    Deceleration (30-60 min) — — 100 
Nonsmokers only (npairs, MZ = 88, DZ =17)    
    Percent change (0-5 min) — — 100 
    Acceleration (0-30 min)* 34.8 (0, 52.4) 0 (0, 0) 65.2 (47.8, 86.0) 
    Deceleration (30-60 min)* 31.0 (0, 48.1) 0 (0, 46.2) 69.0 (51.9, 88.4) 
HR phenotypeSource of variation
A (95% CI)C (95% CI)E (95% CI)
All participants (npairs, MZ = 110, DZ = 29)    
    Percent change (0-5 min) — — 100 
    Acceleration (0-30 min)* 30.3 (0, 46.3) 0 (0, 0) 69.7 (53.7, 87.8) 
    Deceleration (30-60 min) — — 100 
Nonsmokers only (npairs, MZ = 88, DZ =17)    
    Percent change (0-5 min) — — 100 
    Acceleration (0-30 min)* 34.8 (0, 52.4) 0 (0, 0) 65.2 (47.8, 86.0) 
    Deceleration (30-60 min)* 31.0 (0, 48.1) 0 (0, 46.2) 69.0 (51.9, 88.4) 

NOTE: Results are shown for analyses adjusting for age, BMI, current smoking, ethnicity, total nicotine concentration during infusion in the total sample as well as analyses limited to nonsmokers, adjusting for the remaining covariates.

*

Either A or C could be dropped from the model without significant worsening of model fit; dropping both A and C, however, contributed to significant worsening of model fit (P < 0.05).

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