American Association for Cancer Research

Table 1.

Adverse events in healthy volunteers after a single dose of resveratrol

Nature of event*	No. individuals
		Dose level (g)
		0.5	1.0	2.5	5.0
Unlikely to be drug related
Raised urea	1	0	1	0
Raised creatinine	1	0	0	0
Low total protein	1	0	0	0
Raised albumin	0	0	0	1
Raised phosphate	2	0	1	2
Low phosphate	0	1^†	0	0
Raised bilirubin	0	0	1	0
Raised calcium	1	0	0	0
Raised glucose	1	3	1	1
Low CO₂	0	0	2^‡	2
Raised lactate dehydrogenase	1	0	0	1
Low lactate dehydrogenase	0	0	0	1
Raised cholesterol	0	2	0	0
Low WBC count	0	0	1	0
Raised neutrophil count	0	1	0	0
Raised lymphocyte count	0	1	0	0
Raised eosinophil count	0	0	0	1
Low basophil count	0	0	1	0
Raised platelet count	1	1	0	0
Low hematocrit	2	0	0	0
Raised chloride	1	1	0	1
Cellulitic foot infection	0	1	0	0
Flatulence	0	1	0	0
Nausea	0	1	0	0
Loose stool	0	2	0	0
Panic attack	0	1	0	0
Headache	0	1	1	0
Possibly drug related
Raised bilirubin	0	2^‡	0	0
Raised alanine aminotransferase	0	1	0	0

Nature of event*	No. individuals
		Dose level (g)
		0.5	1.0	2.5	5.0
Unlikely to be drug related
Raised urea	1	0	1	0
Raised creatinine	1	0	0	0
Low total protein	1	0	0	0
Raised albumin	0	0	0	1
Raised phosphate	2	0	1	2
Low phosphate	0	1^†	0	0
Raised bilirubin	0	0	1	0
Raised calcium	1	0	0	0
Raised glucose	1	3	1	1
Low CO₂	0	0	2^‡	2
Raised lactate dehydrogenase	1	0	0	1
Low lactate dehydrogenase	0	0	0	1
Raised cholesterol	0	2	0	0
Low WBC count	0	0	1	0
Raised neutrophil count	0	1	0	0
Raised lymphocyte count	0	1	0	0
Raised eosinophil count	0	0	0	1
Low basophil count	0	0	1	0
Raised platelet count	1	1	0	0
Low hematocrit	2	0	0	0
Raised chloride	1	1	0	1
Cellulitic foot infection	0	1	0	0
Flatulence	0	1	0	0
Nausea	0	1	0	0
Loose stool	0	2	0	0
Panic attack	0	1	0	0
Headache	0	1	1	0
Possibly drug related
Raised bilirubin	0	2^‡	0	0
Raised alanine aminotransferase	0	1	0	0

All (except where indicated) National Cancer Institute Common Toxicity Criteria grade 1.

National Cancer Institute Common Toxicity Criteria grade 2.

In one of these two individuals, event was National Cancer Institute Common Toxicity Criteria grade 2.