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Table 3.

Combination of MnSOD, CAT, and GPX1 genetic polymorphisms and risk of prostate cancer in Caucasian

Number of risk alleles*CasesControlsCrude OR (95% CI)OR (95% CI)
31 (7.4) 85 (7.6) 1.0 (ref) 1.0 (ref) 
117 (28.1) 287 (25.7) 1.1 (0.70-1.78) 1.1 (0.69-1.85) 
140 (33.6) 368 (33.0) 1.0 (0.66-1.64) 1.0 (0.59-1.56) 
87 (20.9) 274 (24.5) 0.9 (0.54-1.40) 0.8 (0.51-1.41) 
30 (7.2) 86 (7.7) 1.0 (0.53-1.72) 1.0 (0.52-1.81) 
≥5 12 (2.8) 17 (1.5) 1.9 (0.83-4.51) 1.9 (0.79-4.80) 
     
0–4 405 (97.2) 1,100 (98.5) 1.0 (ref) 1.0 (ref) 
≥5 12 (2.8) 17 (1.5) 1.9 (0.91-4.05) 2.0 (0.90-4.42) 
Number of risk alleles*CasesControlsCrude OR (95% CI)OR (95% CI)
31 (7.4) 85 (7.6) 1.0 (ref) 1.0 (ref) 
117 (28.1) 287 (25.7) 1.1 (0.70-1.78) 1.1 (0.69-1.85) 
140 (33.6) 368 (33.0) 1.0 (0.66-1.64) 1.0 (0.59-1.56) 
87 (20.9) 274 (24.5) 0.9 (0.54-1.40) 0.8 (0.51-1.41) 
30 (7.2) 86 (7.7) 1.0 (0.53-1.72) 1.0 (0.52-1.81) 
≥5 12 (2.8) 17 (1.5) 1.9 (0.83-4.51) 1.9 (0.79-4.80) 
     
0–4 405 (97.2) 1,100 (98.5) 1.0 (ref) 1.0 (ref) 
≥5 12 (2.8) 17 (1.5) 1.9 (0.91-4.05) 2.0 (0.90-4.42) 

NOTE: The subjects with six risk alleles were only two.

*

Risk alleles were defined as MnSOD C allele, CAT T allele, and GPX1 T allele reducing protection against ROS.

ORs adjusting for age at enrollment, history of prostate cancer in first-degree relative, random assignment, smoking status (current versus former or nonsmoker), pack-years smoked (<40, 40-60, ≥60), alcohol consumption (nondrinker, below median, at or above median) and vitamin supplement use in logistic regression model.

P = 0.091.

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