ALOX5 genotype, COX-2 −765 G>C genotype, and risk of adenomatous polyps
| . | COX-2 (−765 G>C) . | . | . | . | . | . | . | . | . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | GG . | . | . | GC . | . | . | CC . | . | . | |||||||||
| . | Controls (N) . | Cases (N) . | OR (95% CI) . | Controls (N) . | Cases (N) . | OR (95% CI) . | Controls (N) . | Cases (N) . | OR (95% CI) . | |||||||||
| ALOX5 −1700 G>A | ||||||||||||||||||
| GG (reference) | 260 | 239 | 1.00 ref. | 111 | 94 | 0.88 (0.61-1.28) | 14 | 6 | 0.36 (0.13-1.02) | |||||||||
| GA or AA | 145 | 103 | 0.73 (0.52-1.02) | 47 | 44 | 0.93 (0.57-1.53) | 5 | 4 | 1.37 (0.25-7.39) | |||||||||
| Pinteraction = 0.07 | ||||||||||||||||||
| . | COX-2 (−765 G>C) . | . | . | . | . | . | . | . | . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | GG . | . | . | GC . | . | . | CC . | . | . | |||||||||
| . | Controls (N) . | Cases (N) . | OR (95% CI) . | Controls (N) . | Cases (N) . | OR (95% CI) . | Controls (N) . | Cases (N) . | OR (95% CI) . | |||||||||
| ALOX5 −1700 G>A | ||||||||||||||||||
| GG (reference) | 260 | 239 | 1.00 ref. | 111 | 94 | 0.88 (0.61-1.28) | 14 | 6 | 0.36 (0.13-1.02) | |||||||||
| GA or AA | 145 | 103 | 0.73 (0.52-1.02) | 47 | 44 | 0.93 (0.57-1.53) | 5 | 4 | 1.37 (0.25-7.39) | |||||||||
| Pinteraction = 0.07 | ||||||||||||||||||
NOTE: Multivariate adjustment for age, sex, smoking (pack-years), alcohol, hormone use, caloric intake, body mass index, and fiber intake.