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Table 4.

ALOX5 genotype, COX-2 −765 G>C genotype, and risk of adenomatous polyps

COX-2 (−765 G>C)
GG
GC
CC
Controls (N)Cases (N)OR (95% CI)Controls (N)Cases (N)OR (95% CI)Controls (N)Cases (N)OR (95% CI)
ALOX5 −1700 G>A          
GG (reference) 260 239 1.00 ref. 111 94 0.88 (0.61-1.28) 14 0.36 (0.13-1.02) 
GA or AA 145 103 0.73 (0.52-1.02) 47 44 0.93 (0.57-1.53) 1.37 (0.25-7.39) 
         Pinteraction = 0.07 
COX-2 (−765 G>C)
GG
GC
CC
Controls (N)Cases (N)OR (95% CI)Controls (N)Cases (N)OR (95% CI)Controls (N)Cases (N)OR (95% CI)
ALOX5 −1700 G>A          
GG (reference) 260 239 1.00 ref. 111 94 0.88 (0.61-1.28) 14 0.36 (0.13-1.02) 
GA or AA 145 103 0.73 (0.52-1.02) 47 44 0.93 (0.57-1.53) 1.37 (0.25-7.39) 
         Pinteraction = 0.07 

NOTE: Multivariate adjustment for age, sex, smoking (pack-years), alcohol, hormone use, caloric intake, body mass index, and fiber intake.

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