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Table 1A.

Study entry criteria

Inclusion: 
 Age over 21. 
 Smoking history ≥30 pack years. 
Exclusion: 
 Inability to provide informed consent (e.g., cognitive impairment, severe psychiatric disorders). 
 Hypersensitivity to grapes and related products. 
 Liver dysfunction (abnormal liver function tests). 
 Renal dysfunction (abnormal serum creatinine). 
 End stage respiratory disease (FEV1 < 0.8 L, resting or exertional hypoxemia, to select patients with adequate reserve to undergo bronchoscopy and complete the study). 
 Unstable angina. 
 Malignancy within 5 years, excluding nonmelanoma type skin cancer or stage I NSCLC post curative resection without evidence of recurrence. 
 Pregnancy. 
 Systemic corticoid steroid therapy. 
 Coagulopathy. 
 Concurrent use of grapes or grape-related products. 
 Unwilling to refrain from drinking more than one glass of wine a day. 
 Patients with concurrent medical conditions that may interfere with completion of tests, therapy, or the follow-up schedule. 
Inclusion: 
 Age over 21. 
 Smoking history ≥30 pack years. 
Exclusion: 
 Inability to provide informed consent (e.g., cognitive impairment, severe psychiatric disorders). 
 Hypersensitivity to grapes and related products. 
 Liver dysfunction (abnormal liver function tests). 
 Renal dysfunction (abnormal serum creatinine). 
 End stage respiratory disease (FEV1 < 0.8 L, resting or exertional hypoxemia, to select patients with adequate reserve to undergo bronchoscopy and complete the study). 
 Unstable angina. 
 Malignancy within 5 years, excluding nonmelanoma type skin cancer or stage I NSCLC post curative resection without evidence of recurrence. 
 Pregnancy. 
 Systemic corticoid steroid therapy. 
 Coagulopathy. 
 Concurrent use of grapes or grape-related products. 
 Unwilling to refrain from drinking more than one glass of wine a day. 
 Patients with concurrent medical conditions that may interfere with completion of tests, therapy, or the follow-up schedule. 
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