Cytogenetic characteristics of patients by Hispanic status
| Cytogenetic characteristic . | . | B-lineage ALL . | . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | ALL . | Hispanic . | Non-Hispanic White . | P . | Total . | |||||
| . | N = 389 n (%) . | N = 151 n (%) . | N = 140 n (%) . | . | N = 356 n (%) . | |||||
| Structural changes | ||||||||||
| t(12;21) | 74 (19.0) | 19 (12.6) | 34 (24.3) | 0.01 | 72 (20.2) | |||||
| t(9;22) | 7 (1.8) | 2 (1.3) | 1 (0.7) | 1.0 | 7 (2.0) | |||||
| E2A translocation | 15 (3.9) | 7 (4.6) | 6 (4.3) | 0.89 | 15 (4.2) | |||||
| 11q23/MLL rearrangements | 14 (3.6) | 3 (2.0) | 4 (2.9) | 0.71 | 14 (3.9) | |||||
| del(12p) | 13 (3.3) | 3 (2.0) | 3 (2.1) | 1.0 | 11 (3.1) | |||||
| del(11q) | 3 (0.8) | 0 (0) | 2 (1.4) | 0.14 | 2 (0.6) | |||||
| del(9p) | 13 (3.3) | 4 (2.7) | 4 (2.9) | 1.0 | 10 (2.8) | |||||
| del(7p) | 1 (0.3) | 0 (0) | 0 (0) | — | 1 (0.3) | |||||
| del(7q) | 1 (0.3) | 1 (0.7) | 0 (0) | 1.0 | 1 (0.3) | |||||
| del(6q) | 18 (4.6) | 6 (4.0) | 6 (4.3) | 0.89 | 14 (3.9) | |||||
| del(5q) | 2 (0.5) | 0 (0) | 1 (0.7) | 0.48 | 1 (0.3) | |||||
| Any deletion | 47 (12.1) | 16 (10.6) | 16 (11.4) | 0.82 | 39 (11.0) | |||||
| Total structural changes | 209 (53.7) | 69 (45.7) | 79 (56.4) | 0.07 | 194 (54.5) | |||||
| Numerical changes | ||||||||||
| Constitutional trisomy 21 | 14 (3.6) | 8 (5.3) | 5 (3.6) | 0.48 | 14 (3.9) | |||||
| Trisomy 8 | 31 (8.0) | 16 (10.6) | 11 (7.9) | 0.42 | 30 (8.4) | |||||
| -Y | 5 (1.3) | 2 (1.3) | 2 (1.4) | 1.0 | 5 (1.4) | |||||
| Monosomy 7 | 9 (2.3) | 1 (0.7) | 5 (3.6) | 0.11 | 7 (2.0) | |||||
| Total numerical changes | 250 (64.3) | 106 (70.2) | 95 (67.9) | 0.67 | 241 (67.7) | |||||
| Ploidy level* | ||||||||||
| Diploid | 61 (15.7) | 23 (15.2) | 17 (12.1) | 0.44 | 45 (12.6) | |||||
| Hyperdiploid (47-67) | 196 (50.4) | 83 (55.0) | 73 (52.1) | 0.63 | 190 (53.4) | |||||
| High hyperdiploid (51-67) | 133 (34.2) | 62 (41.1) | 47 (33.6) | 0.19 | 133 (37.3) | |||||
| Low hyperdiploid (47-50) | 63 (16.2) | 21 (13.9) | 26 (18.6) | 0.28 | 57 (16.0) | |||||
| Hypodiploid 45 | 22 (5.7) | 8 (5.3) | 10 (7.1) | 0.51 | 21 (5.9) | |||||
| Hypodiploid <45 | 4 (1.0) | 1 (0.7) | 2 (1.4) | 0.61 | 3 (0.8) | |||||
| Pseudodiploid | 103 (26.5) | 34 (22.5) | 37 (26.4) | 0.44 | 94 (26.4) | |||||
| Near triploid (68-80) | 3 (0.8) | 2 (1.3) | 1 (0.7) | 1.0 | 3 (0.8) | |||||
| Cytogenetic characteristic . | . | B-lineage ALL . | . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | ALL . | Hispanic . | Non-Hispanic White . | P . | Total . | |||||
| . | N = 389 n (%) . | N = 151 n (%) . | N = 140 n (%) . | . | N = 356 n (%) . | |||||
| Structural changes | ||||||||||
| t(12;21) | 74 (19.0) | 19 (12.6) | 34 (24.3) | 0.01 | 72 (20.2) | |||||
| t(9;22) | 7 (1.8) | 2 (1.3) | 1 (0.7) | 1.0 | 7 (2.0) | |||||
| E2A translocation | 15 (3.9) | 7 (4.6) | 6 (4.3) | 0.89 | 15 (4.2) | |||||
| 11q23/MLL rearrangements | 14 (3.6) | 3 (2.0) | 4 (2.9) | 0.71 | 14 (3.9) | |||||
| del(12p) | 13 (3.3) | 3 (2.0) | 3 (2.1) | 1.0 | 11 (3.1) | |||||
| del(11q) | 3 (0.8) | 0 (0) | 2 (1.4) | 0.14 | 2 (0.6) | |||||
| del(9p) | 13 (3.3) | 4 (2.7) | 4 (2.9) | 1.0 | 10 (2.8) | |||||
| del(7p) | 1 (0.3) | 0 (0) | 0 (0) | — | 1 (0.3) | |||||
| del(7q) | 1 (0.3) | 1 (0.7) | 0 (0) | 1.0 | 1 (0.3) | |||||
| del(6q) | 18 (4.6) | 6 (4.0) | 6 (4.3) | 0.89 | 14 (3.9) | |||||
| del(5q) | 2 (0.5) | 0 (0) | 1 (0.7) | 0.48 | 1 (0.3) | |||||
| Any deletion | 47 (12.1) | 16 (10.6) | 16 (11.4) | 0.82 | 39 (11.0) | |||||
| Total structural changes | 209 (53.7) | 69 (45.7) | 79 (56.4) | 0.07 | 194 (54.5) | |||||
| Numerical changes | ||||||||||
| Constitutional trisomy 21 | 14 (3.6) | 8 (5.3) | 5 (3.6) | 0.48 | 14 (3.9) | |||||
| Trisomy 8 | 31 (8.0) | 16 (10.6) | 11 (7.9) | 0.42 | 30 (8.4) | |||||
| -Y | 5 (1.3) | 2 (1.3) | 2 (1.4) | 1.0 | 5 (1.4) | |||||
| Monosomy 7 | 9 (2.3) | 1 (0.7) | 5 (3.6) | 0.11 | 7 (2.0) | |||||
| Total numerical changes | 250 (64.3) | 106 (70.2) | 95 (67.9) | 0.67 | 241 (67.7) | |||||
| Ploidy level* | ||||||||||
| Diploid | 61 (15.7) | 23 (15.2) | 17 (12.1) | 0.44 | 45 (12.6) | |||||
| Hyperdiploid (47-67) | 196 (50.4) | 83 (55.0) | 73 (52.1) | 0.63 | 190 (53.4) | |||||
| High hyperdiploid (51-67) | 133 (34.2) | 62 (41.1) | 47 (33.6) | 0.19 | 133 (37.3) | |||||
| Low hyperdiploid (47-50) | 63 (16.2) | 21 (13.9) | 26 (18.6) | 0.28 | 57 (16.0) | |||||
| Hypodiploid 45 | 22 (5.7) | 8 (5.3) | 10 (7.1) | 0.51 | 21 (5.9) | |||||
| Hypodiploid <45 | 4 (1.0) | 1 (0.7) | 2 (1.4) | 0.61 | 3 (0.8) | |||||
| Pseudodiploid | 103 (26.5) | 34 (22.5) | 37 (26.4) | 0.44 | 94 (26.4) | |||||
| Near triploid (68-80) | 3 (0.8) | 2 (1.3) | 1 (0.7) | 1.0 | 3 (0.8) | |||||
NOTE: Percentages do not add to 100% because patients may have more than one abnormality. Cases with inadequate karyotypes are not displayed: total, n = 62; too few, n = 2; no bone marrow sample, n = 15; diploid with fewer than 20 metaphases counted, n = 40; only FISH analysis was done and no aberration was identified, n = 5. For B-lineage ALL cases, a total of 65 cases having other ethnicities (n = 54) or unknown ethnicity (n = 11) are not displayed. P values are from Pearson's χ2 statistic or Fisher's exact test (two-tailed probabilities) when expected cell frequencies were five or less.
Pearson's χ2 analysis comparing Hispanics and non-Hispanics: χ2 = 4.10, degrees of freedom = 6, P = 0.66.