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Table 2.

Relation of dietary vitamin D or calcium intake to mammographic densities

MedianMammographic densities*
Model 1 [OR (95% CI)]Model 2 [OR (95% CI)]
≤30% (n = 287)≥70% (n = 256)
Dietary vitamin D, IU/d      
    0–49§ 24 51 64 1.0 1.0 
    50–99 74 57 55 0.51 (0.23–1.11) 0.58 (0.25–1.35) 
    100–199 134 91 72 0.37 (0.18–0.76) 0.55 (0.23–1.31) 
    ≥200 263 88 65 0.24 (0.11–0.53) 0.40 (0.14–1.13) 
    P for trend    0.0005 0.1283 
Dietary calcium, mg/d      
    0–499§ 428 54 62 1.0 1.0 
    500–749 623 78 68 0.63 (0.30–1.32) 0.85 (0.37–1.95) 
    750–999 849 81 54 0.25 (0.11–0.54) 0.39 (0.15–1.00) 
    ≥1,000 1,201 74 72 0.24 (0.10–0.57) 0.47 (0.14–1.53) 
    P for trend    0.0006 0.1760 
MedianMammographic densities*
Model 1 [OR (95% CI)]Model 2 [OR (95% CI)]
≤30% (n = 287)≥70% (n = 256)
Dietary vitamin D, IU/d      
    0–49§ 24 51 64 1.0 1.0 
    50–99 74 57 55 0.51 (0.23–1.11) 0.58 (0.25–1.35) 
    100–199 134 91 72 0.37 (0.18–0.76) 0.55 (0.23–1.31) 
    ≥200 263 88 65 0.24 (0.11–0.53) 0.40 (0.14–1.13) 
    P for trend    0.0005 0.1283 
Dietary calcium, mg/d      
    0–499§ 428 54 62 1.0 1.0 
    500–749 623 78 68 0.63 (0.30–1.32) 0.85 (0.37–1.95) 
    750–999 849 81 54 0.25 (0.11–0.54) 0.39 (0.15–1.00) 
    ≥1,000 1,201 74 72 0.24 (0.10–0.57) 0.47 (0.14–1.53) 
    P for trend    0.0006 0.1760 
*

Percentage of the breast showing mammographic densities.

Model 1: these adjusted models take simultaneously into account the following factors: age, body mass index, age at menarche, number of birth and age at first birth combined, use of oral contraceptive, menopausal status and use of hormone replacement, family history of breast cancer, education, alcohol, total caloric intakes, and smoking status.

Model 2: these adjusted models take simultaneously into account the same covariates as in model 1 and are mutually adjusted for dietary calcium (0–499, 500–749, 750–999, and ≥1,000 mg/d) or vitamin D (0–49, 50–99, 100–199, and ≥200 IU/d) intake, respectively.

§

Reference category.

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