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Table 3

Summary of morphological analysis of sections of small or large intestine from mice treated with vehicle alone (control), 6-TG, trans-AVTG, or cis-AVTP

Values presented are the median scores and range (n = 4). A score of 0 was assigned to normal tissue, and a score of 4 was assigned to tissues with diffuse severe apoptosis or inflammation resulting in loss of normal architecture.

Dose (μmol/kg)Small intestine
Large intestine
One cycleTwo cyclesOne cycleTwo cycles
Control  0 (0) 0 (0–0.5) 0 (0) 0 (0) 
6-TG 8.5 2 (2–3) 3 (2–3) 1 (1) 2 (0.5–2) 
 21.25 3 (2–3) 3 (3–4) 2 (1–2) 1 (0.5–1) 
trans-AVTG 8.5 NDa 1.5 (1–2) ND 0 (0–0.5) 
 21.25 2 (2–3) 2 (2) 0.5 (0–1) 0.25 (0–1) 
cis-AVTP 8.5 ND 0 (0–1) ND 0 (0) 
 21.25 0.75 (0.5–1) 0.25 (0–1) 0 (0) 0 (0) 
Dose (μmol/kg)Small intestine
Large intestine
One cycleTwo cyclesOne cycleTwo cycles
Control  0 (0) 0 (0–0.5) 0 (0) 0 (0) 
6-TG 8.5 2 (2–3) 3 (2–3) 1 (1) 2 (0.5–2) 
 21.25 3 (2–3) 3 (3–4) 2 (1–2) 1 (0.5–1) 
trans-AVTG 8.5 NDa 1.5 (1–2) ND 0 (0–0.5) 
 21.25 2 (2–3) 2 (2) 0.5 (0–1) 0.25 (0–1) 
cis-AVTP 8.5 ND 0 (0–1) ND 0 (0) 
 21.25 0.75 (0.5–1) 0.25 (0–1) 0 (0) 0 (0) 
a

ND, not done.

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