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Table 2

M:E ratio in bone marrow of mice treated with vehicle alone (control), 6-TG, trans-AVTG, or cis-AVTP as described in “Materials and Methods”

Values presented are the means and range (n = 4).

Dose (μmol/kg)M:E ratio (mean and range)
One cycleTwo cycles
Control  1.7:1 (1.5:1–2.3:1) 1.6:1 (1.2:1–1.8:1) 
6-TG 8.5 NDa 11.8:1 (8.1:1–15.7:1) 
 21.25 44.8:1 (32.3:1–49:1) 86.5:1 (49:1–99:1) 
trans-AVTG 8.5 ND 3.2:1 (2.0:1–5.3:1) 
 21.25 6.6:1 (3.0:1–10.1:1) 5.7:1 (4.6:1–7.3:1) 
cis-AVTP 8.5 ND 1.4:1 (1.2:1–1.6:1) 
 21.25 1.8:1 (1.5:1–2.3:1) 1.8:1 (1.3:1–2.2:1) 
Dose (μmol/kg)M:E ratio (mean and range)
One cycleTwo cycles
Control  1.7:1 (1.5:1–2.3:1) 1.6:1 (1.2:1–1.8:1) 
6-TG 8.5 NDa 11.8:1 (8.1:1–15.7:1) 
 21.25 44.8:1 (32.3:1–49:1) 86.5:1 (49:1–99:1) 
trans-AVTG 8.5 ND 3.2:1 (2.0:1–5.3:1) 
 21.25 6.6:1 (3.0:1–10.1:1) 5.7:1 (4.6:1–7.3:1) 
cis-AVTP 8.5 ND 1.4:1 (1.2:1–1.6:1) 
 21.25 1.8:1 (1.5:1–2.3:1) 1.8:1 (1.3:1–2.2:1) 
a

ND, not done.

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