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Table 1

Lack of clastogenic activity of ErPC3 in mice

Compound dose (mg/kg)No. of metaphases analyzed% of cells with aberrationsMitotic index (‰)
ErPC3 124 mg/kg 350a 2.0 ± 1.63 11.12 ± 3.51 
Untreated control 250 0.8 ± 0.4 13.3 ± 4.99 
Mitomycin C 3.5 mg/kg positive control 400b 23.35 ± 0.95 3.06 ± 0.15 
Compound dose (mg/kg)No. of metaphases analyzed% of cells with aberrationsMitotic index (‰)
ErPC3 124 mg/kg 350a 2.0 ± 1.63 11.12 ± 3.51 
Untreated control 250 0.8 ± 0.4 13.3 ± 4.99 
Mitomycin C 3.5 mg/kg positive control 400b 23.35 ± 0.95 3.06 ± 0.15 
a

Bone marrow was prepared at 48 h after application.

b

Bone marrow was prepared at 24 h after application.

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