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Table 4

Lignans and phytoestrogens in urine and serum by treatment and control group

A. Urine Lignans and phytoestrogens
GroupaLignans and phytoestrogens in urine μg/24 h
ENLENDGENDAEQO-DMA
Control 223.93 ± 78.38b 8.34 ± 3.57b 43.65 ± 19.93b 70.35 ± 29.85b 44.78 ± 11.27b 2.54 ± 2.67b 
ENL 1 mg/kg 298.15 ± 70.99b 8.61 ± 5.91b 43.43 ± 15.26b 60.27 ± 21.21b 52.01 ± 13.40b 1.64 ± 1.56b 
ENL 10 mg/kg 610.71 ± 234.9c 10.13 ± 5.66b 35.14 ± 14.66b 77.30 ± 35.34b 30.38 ± 8.02c 5.40 ± 3.00c 
A. Urine Lignans and phytoestrogens
GroupaLignans and phytoestrogens in urine μg/24 h
ENLENDGENDAEQO-DMA
Control 223.93 ± 78.38b 8.34 ± 3.57b 43.65 ± 19.93b 70.35 ± 29.85b 44.78 ± 11.27b 2.54 ± 2.67b 
ENL 1 mg/kg 298.15 ± 70.99b 8.61 ± 5.91b 43.43 ± 15.26b 60.27 ± 21.21b 52.01 ± 13.40b 1.64 ± 1.56b 
ENL 10 mg/kg 610.71 ± 234.9c 10.13 ± 5.66b 35.14 ± 14.66b 77.30 ± 35.34b 30.38 ± 8.02c 5.40 ± 3.00c 
B. Serum lignans and phytoestrogens in treatment and control groups
GroupaLignans and phytoestrogens in serum ng/ml (nm)
ENLENDGENDAEQO-DMA
Control 62.5 ± 26.2b 5.5 ± 2.7b 29.2 ± 14.7b 22.2 ± 9.6b 138.0 ± 59.9b 13.3 ± 9.3b 
 (209.5 ± 87.9) (18.2 ± 8.94) (108.1 ± 54.4) (87.3 ± 37.8) (569.5 ± 247.2) (51.6 ± 36.0) 
ENL 1 mg/kg 68.6 ± 17.3b 4.6 ± 1.7b 30.3 ± 7.8b 25.3 ± 8.0b 161.0 ± 49.3b 9.4 ± 6.2c 
 (230.2 ± 58.1) (15.4 ± 5.6) (112.1 ± 28.9) (99.5 ± 31.5) (664.4 ± 203.5) (36.4 ± 24.0) 
ENL 10 mg/kg 120.8 ± 37.0c 8.4 ± 2.4c 25.8 ± 11.0b 25.0 ± 10.9b 189.0 ± 82.3c 22.4 ± 13.2d 
 (405.4 ± 124.2) (27.8 ± 7.9) (95.5 ± 40.7) (98.3 ± 42.9) (780.0 ± 339.7) (86.8 ± 51.2) 
B. Serum lignans and phytoestrogens in treatment and control groups
GroupaLignans and phytoestrogens in serum ng/ml (nm)
ENLENDGENDAEQO-DMA
Control 62.5 ± 26.2b 5.5 ± 2.7b 29.2 ± 14.7b 22.2 ± 9.6b 138.0 ± 59.9b 13.3 ± 9.3b 
 (209.5 ± 87.9) (18.2 ± 8.94) (108.1 ± 54.4) (87.3 ± 37.8) (569.5 ± 247.2) (51.6 ± 36.0) 
ENL 1 mg/kg 68.6 ± 17.3b 4.6 ± 1.7b 30.3 ± 7.8b 25.3 ± 8.0b 161.0 ± 49.3b 9.4 ± 6.2c 
 (230.2 ± 58.1) (15.4 ± 5.6) (112.1 ± 28.9) (99.5 ± 31.5) (664.4 ± 203.5) (36.4 ± 24.0) 
ENL 10 mg/kg 120.8 ± 37.0c 8.4 ± 2.4c 25.8 ± 11.0b 25.0 ± 10.9b 189.0 ± 82.3c 22.4 ± 13.2d 
 (405.4 ± 124.2) (27.8 ± 7.9) (95.5 ± 40.7) (98.3 ± 42.9) (780.0 ± 339.7) (86.8 ± 51.2) 
a

Rats were gavaged with placebo or with ENL for 7 weeks.

b–d

The letters b, c, d, indicate statistically significant differences in concentrations of measured compounds between the groups (P ≥ 0.05).

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