Selected up-regulated gene products in malignant HNSC vs. normal mucosaa
| GenBank accession no. . | Gene name . | Function . |
|---|---|---|
| AF016098 | Vascular endothelial cell growth factor 165 receptor 2 | Angiogenesis |
| AF024710 | VEGF | Angiogenesis |
| U09278 | Fibroblast activation protein | Angiogenesis |
| M63193 | Platelet-derived endothelial cell growth factor | Angiogenesis |
| AF024710 | VEGF | Angiogenesis |
| AF024710 | VEGF | Angiogenesis |
| M63193 | Platelet-derived endothelial cell growth factor | Angiogenesis |
| L22475 | Bax γ | Apoptosis |
| AF016266 | TRAIL receptor 2 | Apoptosis |
| U50062 | RIP protein kinase | Apoptosis |
| X07820 | Metalloproteinase stromelysin-2 | Cell adhesion |
| X63629 | p cadherin | Cell adhesion |
| D21255 | OB-cadherin-2 | Cell adhesion |
| D21254 | OB-cadherin-1 | Cell adhesion |
| L23808 | Human metalloproteinase | Cell adhesion |
| X53586 | Integrin α 6 | Cell adhesion |
| U37022 | Cyclin-dependent kinase 4 | Cell cycle |
| X51688 | Cyclin A | Cell cycle |
| X00588 | Epidermal growth factor receptor | Cytokine |
| X06374 | Platelet-derived growth factor | Cytokine |
| M38449 | Transforming growth factor-β | Cytokine |
| M34539 | FK506-binding protein | Cytokine modulation |
| X63547 | tre oncogene | Degradation |
| U09759 | JNK2 | MAP kinase pathway |
| U12779 | MAP kinase-activated protein kinase 2 | MAP kinase pathway |
| U25265 | MEK5 | MAP kinase pathway |
| X53416 | Actin-binding protein (filamin) | Structural |
| M13509 | Human skin collagenase | Structural |
| D78577 | 14-3-3 protein | Transcription |
| M29039 | jun-B | Transcriptional regulation |
| V00568 | c-myc | Transcriptional regulation |
| L37882 | Frizzled | wnt pathway |
| AF003837 | Jagged1 | wnt pathway |
| U95299 | Human Notch4 | wnt pathway |
| U81787 | Wnt10B | wnt pathway |
| U07563 | ABL |
| GenBank accession no. . | Gene name . | Function . |
|---|---|---|
| AF016098 | Vascular endothelial cell growth factor 165 receptor 2 | Angiogenesis |
| AF024710 | VEGF | Angiogenesis |
| U09278 | Fibroblast activation protein | Angiogenesis |
| M63193 | Platelet-derived endothelial cell growth factor | Angiogenesis |
| AF024710 | VEGF | Angiogenesis |
| AF024710 | VEGF | Angiogenesis |
| M63193 | Platelet-derived endothelial cell growth factor | Angiogenesis |
| L22475 | Bax γ | Apoptosis |
| AF016266 | TRAIL receptor 2 | Apoptosis |
| U50062 | RIP protein kinase | Apoptosis |
| X07820 | Metalloproteinase stromelysin-2 | Cell adhesion |
| X63629 | p cadherin | Cell adhesion |
| D21255 | OB-cadherin-2 | Cell adhesion |
| D21254 | OB-cadherin-1 | Cell adhesion |
| L23808 | Human metalloproteinase | Cell adhesion |
| X53586 | Integrin α 6 | Cell adhesion |
| U37022 | Cyclin-dependent kinase 4 | Cell cycle |
| X51688 | Cyclin A | Cell cycle |
| X00588 | Epidermal growth factor receptor | Cytokine |
| X06374 | Platelet-derived growth factor | Cytokine |
| M38449 | Transforming growth factor-β | Cytokine |
| M34539 | FK506-binding protein | Cytokine modulation |
| X63547 | tre oncogene | Degradation |
| U09759 | JNK2 | MAP kinase pathway |
| U12779 | MAP kinase-activated protein kinase 2 | MAP kinase pathway |
| U25265 | MEK5 | MAP kinase pathway |
| X53416 | Actin-binding protein (filamin) | Structural |
| M13509 | Human skin collagenase | Structural |
| D78577 | 14-3-3 protein | Transcription |
| M29039 | jun-B | Transcriptional regulation |
| V00568 | c-myc | Transcriptional regulation |
| L37882 | Frizzled | wnt pathway |
| AF003837 | Jagged1 | wnt pathway |
| U95299 | Human Notch4 | wnt pathway |
| U81787 | Wnt10B | wnt pathway |
| U07563 | ABL |
TRAIL, tumor necrosis factor-related apoptosis-inducing ligand; JNK, c-Jun NH2-terminal kinase; MEK, MAP/extracellular signal-regulated kinase kinase; ABL, Abelson; RIP, receptor interacting protein.