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Table 2

Selected up-regulated gene products in malignant HNSC vs. normal mucosaa

GenBank accession no.Gene nameFunction
AF016098 Vascular endothelial cell growth factor 165 receptor 2 Angiogenesis 
AF024710 VEGF Angiogenesis 
U09278 Fibroblast activation protein Angiogenesis 
M63193 Platelet-derived endothelial cell growth factor Angiogenesis 
AF024710 VEGF Angiogenesis 
AF024710 VEGF Angiogenesis 
M63193 Platelet-derived endothelial cell growth factor Angiogenesis 
L22475 Bax γ Apoptosis 
AF016266 TRAIL receptor 2 Apoptosis 
U50062 RIP protein kinase Apoptosis 
X07820 Metalloproteinase stromelysin-2 Cell adhesion 
X63629 p cadherin Cell adhesion 
D21255 OB-cadherin-2 Cell adhesion 
D21254 OB-cadherin-1 Cell adhesion 
L23808 Human metalloproteinase Cell adhesion 
X53586 Integrin α 6 Cell adhesion 
U37022 Cyclin-dependent kinase 4 Cell cycle 
X51688 Cyclin A Cell cycle 
X00588 Epidermal growth factor receptor Cytokine 
X06374 Platelet-derived growth factor Cytokine 
M38449 Transforming growth factor-β Cytokine 
M34539 FK506-binding protein Cytokine modulation 
X63547 tre oncogene Degradation 
U09759 JNK2 MAP kinase pathway 
U12779 MAP kinase-activated protein kinase 2 MAP kinase pathway 
U25265 MEK5 MAP kinase pathway 
X53416 Actin-binding protein (filamin) Structural 
M13509 Human skin collagenase Structural 
D78577 14-3-3 protein Transcription 
M29039 jun-B Transcriptional regulation 
V00568 c-myc Transcriptional regulation 
L37882 Frizzled wnt pathway 
AF003837 Jagged1 wnt pathway 
U95299 Human Notch4 wnt pathway 
U81787 Wnt10B wnt pathway 
U07563 ABL  
GenBank accession no.Gene nameFunction
AF016098 Vascular endothelial cell growth factor 165 receptor 2 Angiogenesis 
AF024710 VEGF Angiogenesis 
U09278 Fibroblast activation protein Angiogenesis 
M63193 Platelet-derived endothelial cell growth factor Angiogenesis 
AF024710 VEGF Angiogenesis 
AF024710 VEGF Angiogenesis 
M63193 Platelet-derived endothelial cell growth factor Angiogenesis 
L22475 Bax γ Apoptosis 
AF016266 TRAIL receptor 2 Apoptosis 
U50062 RIP protein kinase Apoptosis 
X07820 Metalloproteinase stromelysin-2 Cell adhesion 
X63629 p cadherin Cell adhesion 
D21255 OB-cadherin-2 Cell adhesion 
D21254 OB-cadherin-1 Cell adhesion 
L23808 Human metalloproteinase Cell adhesion 
X53586 Integrin α 6 Cell adhesion 
U37022 Cyclin-dependent kinase 4 Cell cycle 
X51688 Cyclin A Cell cycle 
X00588 Epidermal growth factor receptor Cytokine 
X06374 Platelet-derived growth factor Cytokine 
M38449 Transforming growth factor-β Cytokine 
M34539 FK506-binding protein Cytokine modulation 
X63547 tre oncogene Degradation 
U09759 JNK2 MAP kinase pathway 
U12779 MAP kinase-activated protein kinase 2 MAP kinase pathway 
U25265 MEK5 MAP kinase pathway 
X53416 Actin-binding protein (filamin) Structural 
M13509 Human skin collagenase Structural 
D78577 14-3-3 protein Transcription 
M29039 jun-B Transcriptional regulation 
V00568 c-myc Transcriptional regulation 
L37882 Frizzled wnt pathway 
AF003837 Jagged1 wnt pathway 
U95299 Human Notch4 wnt pathway 
U81787 Wnt10B wnt pathway 
U07563 ABL  
a

TRAIL, tumor necrosis factor-related apoptosis-inducing ligand; JNK, c-Jun NH2-terminal kinase; MEK, MAP/extracellular signal-regulated kinase kinase; ABL, Abelson; RIP, receptor interacting protein.

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