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Table 3

Invasion through Matrigel-coated membrane by bladder cancer cells after treatment with ABX-IL8

TreatmentMean number of invading cells ± SD, per membranea
253J B-VUMUC-3253J S-IL8
Control 125 ± 44 135 ± 49 113 ± 43 
IgG (100 μg/ml) 90 ± 50 115 ± 40 97 ± 37 
ABX-IL8 (100 μg/ml) 26 ± 9b 37 ± 10b 50 ± 20b 
TreatmentMean number of invading cells ± SD, per membranea
253J B-VUMUC-3253J S-IL8
Control 125 ± 44 135 ± 49 113 ± 43 
IgG (100 μg/ml) 90 ± 50 115 ± 40 97 ± 37 
ABX-IL8 (100 μg/ml) 26 ± 9b 37 ± 10b 50 ± 20b 
a

A total of 5 × 103 cells was plated in the invasion chambers after treatment with ABX-IL8 or IgG for 3 days, suspended in serum-free media. Cells that had invaded and migrated were counted on the lower surface of the membrane. Experiment performed twice in triplicates.

b

All Ps < 0.01.

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