American Association for Cancer Research

Table 3

Invasion through Matrigel-coated membrane by bladder cancer cells after treatment with ABX-IL8

Treatment	Mean number of invading cells ± SD, per membrane^a
Treatment		253J B-V	UMUC-3	253J S-IL8
Control	125 ± 44	135 ± 49	113 ± 43
IgG (100 μg/ml)	90 ± 50	115 ± 40	97 ± 37
ABX-IL8 (100 μg/ml)	26 ± 9^b	37 ± 10^b	50 ± 20^b

Treatment	Mean number of invading cells ± SD, per membrane^a
Treatment		253J B-V	UMUC-3	253J S-IL8
Control	125 ± 44	135 ± 49	113 ± 43
IgG (100 μg/ml)	90 ± 50	115 ± 40	97 ± 37
ABX-IL8 (100 μg/ml)	26 ± 9^b	37 ± 10^b	50 ± 20^b

A total of 5 × 10³ cells was plated in the invasion chambers after treatment with ABX-IL8 or IgG for 3 days, suspended in serum-free media. Cells that had invaded and migrated were counted on the lower surface of the membrane. Experiment performed twice in triplicates.

All Ps < 0.01.

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