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Table 2

Expression of MMP-2 and MMP-9 mRNA in vitro after treatment with ABX-IL8 and control IgG

Mean optical density ± SDa
MMP-9MMP-2
Control IgGABX-IL8Control IgGABX-IL8
253 J B-V 3.8 ± 0.77 2.5 ± 0.40b 3.9 ± 0.46 2.9 ± 0.44b 
253 J S-IL8 4.2 ± 0.46 3.8 ± 0.46b 4.4 ± 0.37 3.6 ± 0.39b 
UMUC-3 N/Ac N/A 3.7 ± 0.42 3.1 ± 0.38b 
Mean optical density ± SDa
MMP-9MMP-2
Control IgGABX-IL8Control IgGABX-IL8
253 J B-V 3.8 ± 0.77 2.5 ± 0.40b 3.9 ± 0.46 2.9 ± 0.44b 
253 J S-IL8 4.2 ± 0.46 3.8 ± 0.46b 4.4 ± 0.37 3.6 ± 0.39b 
UMUC-3 N/Ac N/A 3.7 ± 0.42 3.1 ± 0.38b 
a

Colorimetric in situ hybridization was performed in triplicates, and the intensity of color reaction was quantified in 5–10 areas in at least five high power fields/slide. This is one representative experiment of two.

b

All Ps < 0.01, when compared with controls.

c

N/A, not available as MMP-9 expressed at very low levels in UMUC-3 cells.

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