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Table 1

Tumorigenicity of UMUC-3 and 253J B-V cells implanted orthotopically in the bladder wall of nude mice

Values are the average of two representative experiments of four

Ps were calculated using the Mann Whitney U test

GroupMedian tumor weight (range), mg
UMUC-3aIncidence253J B-VbIncidence
Untreated Control 853  194  
 (227–1301) 10/10 (114–269) 10/10 
Control IgG 534  179  
 (182–979) 10/10 (51–296) 10/10 
ABX-IL8 380c  145  
 (151–762) 10/10 (56–195) 10/10 
GroupMedian tumor weight (range), mg
UMUC-3aIncidence253J B-VbIncidence
Untreated Control 853  194  
 (227–1301) 10/10 (114–269) 10/10 
Control IgG 534  179  
 (182–979) 10/10 (51–296) 10/10 
ABX-IL8 380c  145  
 (151–762) 10/10 (56–195) 10/10 
a

UMUC-3 cells (5 × 104) were implanted in the bladder wall of athymic nude mice (10 mice/group) and treated with ABX-IL8 or control IgG, 1000 μg, i.p., once/week for 4 weeks.

b

253J B-V cells (25 × 104) were implanted and treated as above with ABX-IL8 or control IgG, 100 μg, i.p., three/week for 3 weeks.

c

P < 0.02 versus untreated controls.

d

P < 0.05.

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