American Association for Cancer Research

Table 1

Tumorigenicity of UMUC-3 and 253J B-V cells implanted orthotopically in the bladder wall of nude mice

Values are the average of two representative experiments of four

Ps were calculated using the Mann Whitney U test

Group	Median tumor weight (range), mg
Group		UMUC-3^a	Incidence	253J B-V^b	Incidence
Untreated Control	853		194
	(227–1301)	10/10	(114–269)	10/10
Control IgG	534		179
	(182–979)	10/10	(51–296)	10/10
ABX-IL8	380^c		145
	(151–762)	10/10	(56–195)	10/10

Group	Median tumor weight (range), mg
Group		UMUC-3^a	Incidence	253J B-V^b	Incidence
Untreated Control	853		194
	(227–1301)	10/10	(114–269)	10/10
Control IgG	534		179
	(182–979)	10/10	(51–296)	10/10
ABX-IL8	380^c		145
	(151–762)	10/10	(56–195)	10/10

UMUC-3 cells (5 × 10⁴) were implanted in the bladder wall of athymic nude mice (10 mice/group) and treated with ABX-IL8 or control IgG, 1000 μg, i.p., once/week for 4 weeks.

253J B-V cells (25 × 10⁴) were implanted and treated as above with ABX-IL8 or control IgG, 100 μg, i.p., three/week for 3 weeks.

P < 0.02 versus untreated controls.

P < 0.05.

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