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Table 2

Distribution of molecular abnormalities according to histological grade of preinvasive bronchial lesions

LesionsP53P16INK4Cyclin D1Cyclin EBBR < 1a
Metaplasia 3% (1/31) 12% (3/25) 6% (2/31) 3% (1/31) 3% (1/31) 
MD 50% (6/12) 17% (2/12) 25% (3/12) 25% (3/12) 
MD 33% (3/9) 22% (2/9) 67% (6/9) 33% (3/9) 67% (6/9) 
SD 78% (7/9) 14% (1/7) 56% (5/9) 55% (5/9) 78% (7/9) 
CIS 63% (12/19) 47% (8/17) 53% (10/19) 89% (17/19) 53% (10/19) 
Pa P < 0.001 P < 0.01 P < 0.001 P < 0.001 P < 0.001 
LesionsP53P16INK4Cyclin D1Cyclin EBBR < 1a
Metaplasia 3% (1/31) 12% (3/25) 6% (2/31) 3% (1/31) 3% (1/31) 
MD 50% (6/12) 17% (2/12) 25% (3/12) 25% (3/12) 
MD 33% (3/9) 22% (2/9) 67% (6/9) 33% (3/9) 67% (6/9) 
SD 78% (7/9) 14% (1/7) 56% (5/9) 55% (5/9) 78% (7/9) 
CIS 63% (12/19) 47% (8/17) 53% (10/19) 89% (17/19) 53% (10/19) 
Pa P < 0.001 P < 0.01 P < 0.001 P < 0.001 P < 0.001 
a

P, probability of difference in distribution between low-grade (metaplasia and MD) and high-grade lesions (MD, SD, and CIS; Fisher’s exact test).

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