Distribution of molecular abnormalities according to histological grade of preinvasive bronchial lesions
| Lesions . | P53 . | P16INK4 . | Cyclin D1 . | Cyclin E . | BBR < 1a . |
|---|---|---|---|---|---|
| Metaplasia | 3% (1/31) | 12% (3/25) | 6% (2/31) | 3% (1/31) | 3% (1/31) |
| MD | 50% (6/12) | 0 | 17% (2/12) | 25% (3/12) | 25% (3/12) |
| MD | 33% (3/9) | 22% (2/9) | 67% (6/9) | 33% (3/9) | 67% (6/9) |
| SD | 78% (7/9) | 14% (1/7) | 56% (5/9) | 55% (5/9) | 78% (7/9) |
| CIS | 63% (12/19) | 47% (8/17) | 53% (10/19) | 89% (17/19) | 53% (10/19) |
| Pa | P < 0.001 | P < 0.01 | P < 0.001 | P < 0.001 | P < 0.001 |
| Lesions . | P53 . | P16INK4 . | Cyclin D1 . | Cyclin E . | BBR < 1a . |
|---|---|---|---|---|---|
| Metaplasia | 3% (1/31) | 12% (3/25) | 6% (2/31) | 3% (1/31) | 3% (1/31) |
| MD | 50% (6/12) | 0 | 17% (2/12) | 25% (3/12) | 25% (3/12) |
| MD | 33% (3/9) | 22% (2/9) | 67% (6/9) | 33% (3/9) | 67% (6/9) |
| SD | 78% (7/9) | 14% (1/7) | 56% (5/9) | 55% (5/9) | 78% (7/9) |
| CIS | 63% (12/19) | 47% (8/17) | 53% (10/19) | 89% (17/19) | 53% (10/19) |
| Pa | P < 0.001 | P < 0.01 | P < 0.001 | P < 0.001 | P < 0.001 |
P, probability of difference in distribution between low-grade (metaplasia and MD) and high-grade lesions (MD, SD, and CIS; Fisher’s exact test).