Imatinib distribution in murine organs
Tumor-bearing nude mice were treated with imatinib (160 mg/kg) with or without CLI (350 mg/kg) p.o. Two h after dosing, animals were killed and organs extracted.
| Organ . | Imatinib (160 mg/kg) . | . | Imatinib (160 mg/kg) + CLI (350 mg/kg) . | . | P . | ||
|---|---|---|---|---|---|---|---|
| . | Mean (μg/g) . | 95% CI . | Mean (μg/g) . | 95% CI . | . | ||
| Liver | 49.6 | ±18.7 | 101.3 | ±35.6 | <0.01 | ||
| Spleen | 74.5 | ±24.3 | 132.3 | ±44.1 | <0.01 | ||
| Kidney | 49.3 | ±17.6 | 100.8 | ±41.5 | 0.01 | ||
| Intestine | 49.1 | ±24.1 | 69.7 | ±26.5 | 0.06 | ||
| Tumor | 30.3 | ±10.8 | 57.8 | ±13.7 | 0.03 | ||
| Organ . | Imatinib (160 mg/kg) . | . | Imatinib (160 mg/kg) + CLI (350 mg/kg) . | . | P . | ||
|---|---|---|---|---|---|---|---|
| . | Mean (μg/g) . | 95% CI . | Mean (μg/g) . | 95% CI . | . | ||
| Liver | 49.6 | ±18.7 | 101.3 | ±35.6 | <0.01 | ||
| Spleen | 74.5 | ±24.3 | 132.3 | ±44.1 | <0.01 | ||
| Kidney | 49.3 | ±17.6 | 100.8 | ±41.5 | 0.01 | ||
| Intestine | 49.1 | ±24.1 | 69.7 | ±26.5 | 0.06 | ||
| Tumor | 30.3 | ±10.8 | 57.8 | ±13.7 | 0.03 | ||