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Table 4

Imatinib distribution in murine organs

Tumor-bearing nude mice were treated with imatinib (160 mg/kg) with or without CLI (350 mg/kg) p.o. Two h after dosing, animals were killed and organs extracted.

OrganImatinib (160 mg/kg)Imatinib (160 mg/kg) + CLI (350 mg/kg)P
Mean (μg/g)95% CIMean (μg/g)95% CI
Liver 49.6 ±18.7 101.3 ±35.6 <0.01 
Spleen 74.5 ±24.3 132.3 ±44.1 <0.01 
Kidney 49.3 ±17.6 100.8 ±41.5 0.01 
Intestine 49.1 ±24.1 69.7 ±26.5 0.06 
Tumor 30.3 ±10.8 57.8 ±13.7 0.03 
OrganImatinib (160 mg/kg)Imatinib (160 mg/kg) + CLI (350 mg/kg)P
Mean (μg/g)95% CIMean (μg/g)95% CI
Liver 49.6 ±18.7 101.3 ±35.6 <0.01 
Spleen 74.5 ±24.3 132.3 ±44.1 <0.01 
Kidney 49.3 ±17.6 100.8 ±41.5 0.01 
Intestine 49.1 ±24.1 69.7 ±26.5 0.06 
Tumor 30.3 ±10.8 57.8 ±13.7 0.03 
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