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Table 3

Effect of the administration of CLI (900 mg i.v. over 20 min) on imatinib plasma concentrations (μg/ml)

Three patients at SS received an i.v. infusion of CLI (900 mg over 20 minutes), 23 h after the last dose of imatinib. Five and 10 min after the end of CLI infusion, blood samples were obtained and total imatinib concentrations assessed.

Patient no.Imatinib dosageDisease phasePre-CLI5 min post-CLI10 min post-CLI
008 600 BC 7.85 1.66 1.68 
00213 400 CP 0.32 0.12 0.12 
00241 400 CP 0.35 0.14 0.13 
Patient no.Imatinib dosageDisease phasePre-CLI5 min post-CLI10 min post-CLI
008 600 BC 7.85 1.66 1.68 
00213 400 CP 0.32 0.12 0.12 
00241 400 CP 0.35 0.14 0.13 
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