Effect of the administration of CLI (900 mg i.v. over 20 min) on imatinib plasma concentrations (μg/ml)
Three patients at SS received an i.v. infusion of CLI (900 mg over 20 minutes), 23 h after the last dose of imatinib. Five and 10 min after the end of CLI infusion, blood samples were obtained and total imatinib concentrations assessed.
| Patient no. . | Imatinib dosage . | Disease phase . | Pre-CLI . | 5 min post-CLI . | 10 min post-CLI . |
|---|---|---|---|---|---|
| 008 | 600 | BC | 7.85 | 1.66 | 1.68 |
| 00213 | 400 | CP | 0.32 | 0.12 | 0.12 |
| 00241 | 400 | CP | 0.35 | 0.14 | 0.13 |
| Patient no. . | Imatinib dosage . | Disease phase . | Pre-CLI . | 5 min post-CLI . | 10 min post-CLI . |
|---|---|---|---|---|---|
| 008 | 600 | BC | 7.85 | 1.66 | 1.68 |
| 00213 | 400 | CP | 0.32 | 0.12 | 0.12 |
| 00241 | 400 | CP | 0.35 | 0.14 | 0.13 |