Skip to Main Content
Table 2

Effect of CLI on the PK parameters of imatinib and on its binding to plasma proteins

PatientDay 4aDay 5f
Cmaxb (μg/ml)AUCc (μg/ml h)Clssd (liter/h)Vssd (liter)% boundFree imatinibe (μg/ml)Cmax (μg/ml)AUC (μg/ml h)Clss (liter/h)Vss (liter)% boundFree imatinib (μg/ml)
001 8.09 70.47 5.68 84.7 99.5 0.04 1.79 30.20 13.25 172.6 98.5 0.052 
002 2.90 42.70 9.37 185.2 97.4 0.0654 1.04 14.30 27.97 585.3 93.8 0.0645 
0503 3.06 43.20 9.26 152.3 99.2 0.0245 0.73 16.59 24.11 434.9 94.6 0.0394 
0502 7.08 97.70 4.09 86.3 99.5 0.0354 1.57 20.00 20.00 519.5 95.5 0.0707 
0501 2.49 33.38 11.98 266.8 99.5 0.0125 1.02 16.40 24.39 876.4 97.6 0.0245 
             
             
Mean 4.72 57.49 8.08 155.1 99.02 0.035 1.43 19.50 21.94 517.7 96.0 0.051 
95% CI 3.30 23.15 2.77 66.6 1.07 0.02 1.02 5.54 4.93 223.1 2.41 0.019 
PatientDay 4aDay 5f
Cmaxb (μg/ml)AUCc (μg/ml h)Clssd (liter/h)Vssd (liter)% boundFree imatinibe (μg/ml)Cmax (μg/ml)AUC (μg/ml h)Clss (liter/h)Vss (liter)% boundFree imatinib (μg/ml)
001 8.09 70.47 5.68 84.7 99.5 0.04 1.79 30.20 13.25 172.6 98.5 0.052 
002 2.90 42.70 9.37 185.2 97.4 0.0654 1.04 14.30 27.97 585.3 93.8 0.0645 
0503 3.06 43.20 9.26 152.3 99.2 0.0245 0.73 16.59 24.11 434.9 94.6 0.0394 
0502 7.08 97.70 4.09 86.3 99.5 0.0354 1.57 20.00 20.00 519.5 95.5 0.0707 
0501 2.49 33.38 11.98 266.8 99.5 0.0125 1.02 16.40 24.39 876.4 97.6 0.0245 
             
             
Mean 4.72 57.49 8.08 155.1 99.02 0.035 1.43 19.50 21.94 517.7 96.0 0.051 
95% CI 3.30 23.15 2.77 66.6 1.07 0.02 1.02 5.54 4.93 223.1 2.41 0.019 
a

Day 4 refers to PK performed at SS.

b

Cmax values were obtained from experimental data.

c

AUCs were calculated by trapezoidal rule.

d

Clearance (Clss) and the volume of distribution (Vss) were calculated as described in “Patients and Methods.”

e

The percentage of free imatinib and free imatinib concentrations were experimentally measured by ultrafiltration and HPLC determination.

f

Day 5 refers to PK performed during CLI infusion, 24 h after the day 4 PK.

Close Modal

or Create an Account

Close Modal
Close Modal