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Table 3

Logistic regression models for adverse events at cycle 1

End pointaPredictorPOdds ratiob (95% CI)
TOX AUC (4.2–6.5 μg·h/ml) 0.0021 1.81 (1.24–2.64) 
TOX1 AUC (4.2–6.5 μg·h/ml) 0.0005 2.37 (1.46–3.87) 
 AAG (1.11–1.85 grams/liter) 0.0505 0.47 (0.22–1.00) 
End pointaPredictorPOdds ratiob (95% CI)
TOX AUC (4.2–6.5 μg·h/ml) 0.0021 1.81 (1.24–2.64) 
TOX1 AUC (4.2–6.5 μg·h/ml) 0.0005 2.37 (1.46–3.87) 
 AAG (1.11–1.85 grams/liter) 0.0505 0.47 (0.22–1.00) 
a

See Table 2 for definition of end points.

b

Odds ratio for covariate change from 25th to 75th percentiles for AUC and AAG.

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