Total number of lesions, response assessments, response ranks, and response categories in six sample patients, analyzing groupings of five lesions with RECIST criteria

Patient 4 has response assessments falling into three different categories, but the proportion falling in RANK1 is very high (92%); in contrast, patient 3 has response assessments falling into fewer (two) categories, but RANK1 is only 60%. A large proportion of lesion combinations (40%) will fall into a second response category. Therefore, patient 3 is nearly evenly split between two response categories, whereas patient 4’s response almost always (92%) falls into one category (but with the potential for two other response categories 8% of the time).