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Table 3

Effect of bryostatin-1 on plasma cytokine levels; pg/ml (mean ± SD)

Time from start of infusionCycle 1: mean ± SDCycle 2: mean ± SD
Baseline 02 h24 hBaseline2 h24 h
IL-6 14.75 ± 17.02 19.36 ± 23.5 21.89 ± 25.2a 13.12 ± 15.6 16.52 ± 19.2 29.97 ± 58a 
TNF-α 13.24 ± 6.6 9.31 ± 4.4b 16.1 ± 13.2 13.53 ± 9.3 10.16 ± 7.26b 11.4 ± 8.5 
CRP 3.87 ± 5.8 3.75 ± 5.6 5.86 ± 8.6 4.47 ± 6.6 4.17 ± 6.6 3.06 ± 6.1 
Time from start of infusionCycle 1: mean ± SDCycle 2: mean ± SD
Baseline 02 h24 hBaseline2 h24 h
IL-6 14.75 ± 17.02 19.36 ± 23.5 21.89 ± 25.2a 13.12 ± 15.6 16.52 ± 19.2 29.97 ± 58a 
TNF-α 13.24 ± 6.6 9.31 ± 4.4b 16.1 ± 13.2 13.53 ± 9.3 10.16 ± 7.26b 11.4 ± 8.5 
CRP 3.87 ± 5.8 3.75 ± 5.6 5.86 ± 8.6 4.47 ± 6.6 4.17 ± 6.6 3.06 ± 6.1 
a

Significantly different from pretreatment level (P = 0.02).

b

Significantly different from pretreatment level (P = 0.02) and 24-h level (P = 0.01).

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