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Table 3

Effect of bryostatin-1 on plasma cytokine levels; pg/ml (mean ± SD)

Time from start of infusion	Cycle 1: mean ± SD					Cycle 2: mean ± SD
Time from start of infusion		Baseline 0	2 h	24 h	Baseline	2 h	24 h
IL-6	14.75 ± 17.02	19.36 ± 23.5	21.89 ± 25.2^a	13.12 ± 15.6	16.52 ± 19.2	29.97 ± 58^a
TNF-α	13.24 ± 6.6	9.31 ± 4.4^b	16.1 ± 13.2	13.53 ± 9.3	10.16 ± 7.26^b	11.4 ± 8.5
CRP	3.87 ± 5.8	3.75 ± 5.6	5.86 ± 8.6	4.47 ± 6.6	4.17 ± 6.6	3.06 ± 6.1

Time from start of infusion	Cycle 1: mean ± SD					Cycle 2: mean ± SD
Time from start of infusion		Baseline 0	2 h	24 h	Baseline	2 h	24 h
IL-6	14.75 ± 17.02	19.36 ± 23.5	21.89 ± 25.2^a	13.12 ± 15.6	16.52 ± 19.2	29.97 ± 58^a
TNF-α	13.24 ± 6.6	9.31 ± 4.4^b	16.1 ± 13.2	13.53 ± 9.3	10.16 ± 7.26^b	11.4 ± 8.5
CRP	3.87 ± 5.8	3.75 ± 5.6	5.86 ± 8.6	4.47 ± 6.6	4.17 ± 6.6	3.06 ± 6.1

^a

Significantly different from pretreatment level (P = 0.02).

^b

Significantly different from pretreatment level (P = 0.02) and 24-h level (P = 0.01).