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Table 3

Summary of steady-state concentrations of ISIS 3521 and ISIS 5132a

AgentSample dayNo. patientsParent oligonucleotide (μg/ml)Total oligonucleotide (μg/ml)% Intact
ISIS 3521 0.92 ± 0.37 1.70 ± 0.74 54.27 ± 4.07 
 15 0.98 ± 0.61 1.78 ± 1.00 54.51 ± 6.37 
 22 0.76 ± 0.27 1.42 ± 0.66 56.05 ± 9.79 
Mean Cssb   0.89 ± 0.43 1.65 ± 0.79  
ISIS 5132 0.73 ± 0.34 1.20 ± 0.64 61.88 ± 7.94 
 15 11 0.61 ± 0.33 1.08 ± 0.56 57.46 ± 10.31 
 22 11 0.60 ± 0.30 1.05 ± 0.57 58.14 ± 11.48 
Mean Cssb   0.63 ± 0.31 1.10 ± 0.57  
AgentSample dayNo. patientsParent oligonucleotide (μg/ml)Total oligonucleotide (μg/ml)% Intact
ISIS 3521 0.92 ± 0.37 1.70 ± 0.74 54.27 ± 4.07 
 15 0.98 ± 0.61 1.78 ± 1.00 54.51 ± 6.37 
 22 0.76 ± 0.27 1.42 ± 0.66 56.05 ± 9.79 
Mean Cssb   0.89 ± 0.43 1.65 ± 0.79  
ISIS 5132 0.73 ± 0.34 1.20 ± 0.64 61.88 ± 7.94 
 15 11 0.61 ± 0.33 1.08 ± 0.56 57.46 ± 10.31 
 22 11 0.60 ± 0.30 1.05 ± 0.57 58.14 ± 11.48 
Mean Cssb   0.63 ± 0.31 1.10 ± 0.57  
a

Values represent means (± SD).

b

Mean Css, average concentration of days 8, 15, and 22.

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