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Table 2

Worst hematologic toxicity by patient

ToxicityISIS 3521ISIS 5132
Number of evaluable patients 14 16 
Median nadir (range)   
 ANC (×109/liter) 2.50 (1.7–3.8) 2.65 (1.7–4.0) 
 WBC (×109/liter) 4.2 (2.8–5.5) 4.6 (2.6–5.9) 
 Platelet (×109/liter) 98 (9–149) 129 (48–195) 
 Hemoglobin (g/liter) 109 (76–131) 122 (80–145) 
Median number of days to nadir (range)   
 ANC 43 (8–162) 42 (15–83) 
 WBC 50 (15–162) 29 (15–83) 
 Platelet 22 (14–162) 42 (15–136) 
 Hemoglobin 53 (28–162) 50 (8–92) 
ToxicityISIS 3521ISIS 5132
Number of evaluable patients 14 16 
Median nadir (range)   
 ANC (×109/liter) 2.50 (1.7–3.8) 2.65 (1.7–4.0) 
 WBC (×109/liter) 4.2 (2.8–5.5) 4.6 (2.6–5.9) 
 Platelet (×109/liter) 98 (9–149) 129 (48–195) 
 Hemoglobin (g/liter) 109 (76–131) 122 (80–145) 
Median number of days to nadir (range)   
 ANC 43 (8–162) 42 (15–83) 
 WBC 50 (15–162) 29 (15–83) 
 Platelet 22 (14–162) 42 (15–136) 
 Hemoglobin 53 (28–162) 50 (8–92) 
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