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Table 1

Patient characteristics

CharacteristicISIS 3521ISIS 5132Total
Number of patients 14 16 30 
Median age (range) 72 (58–78) 66 (52–81) 69 (52–81) 
Performance status    
 0 10 17 
 1 13 
Previous therapy    
 Radiation therapy 10 19 
 Surgical castration    
 LHRH agonist    
Time from diagnosis to study entry    
 12–24 months 
 >24 months 11 16 27 
Sites of disease    
 Bone 12 14 26 
 Lymph nodes 10 
 Prostate 
Measurable disease    
 Bidimensional 10 
 Nonmeasurable 10 10 20 
Baseline PSA value (ng/ml)    
 <50 
 50–99 
 100–199 
 200–399 
 ≥400 
CharacteristicISIS 3521ISIS 5132Total
Number of patients 14 16 30 
Median age (range) 72 (58–78) 66 (52–81) 69 (52–81) 
Performance status    
 0 10 17 
 1 13 
Previous therapy    
 Radiation therapy 10 19 
 Surgical castration    
 LHRH agonist    
Time from diagnosis to study entry    
 12–24 months 
 >24 months 11 16 27 
Sites of disease    
 Bone 12 14 26 
 Lymph nodes 10 
 Prostate 
Measurable disease    
 Bidimensional 10 
 Nonmeasurable 10 10 20 
Baseline PSA value (ng/ml)    
 <50 
 50–99 
 100–199 
 200–399 
 ≥400 
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