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Table 2

Cytokines modifications after a single infusion of Pamidronate

Median value (pg/dl)95% CI (pg/dl)P (Mann-Whitney U test)
VEGF    
 Basal levels 745.00 654.80–986.26  
 1 day 602.49 424.06–753.25 0.019 
 2 days 556.84 358.3–640.71 0.001 
 7 days 556.88 442.49–684.28 0.03 
γ-IFN    
 Basal levels 12.00 11.25–18.65  
 1 day 21.28 18.43–28.65 0.003 
 2 days 11.53 11.70–18.39 n.s. 
 7 days 9.725 10.17–16.48 n.s. 
IL-6    
 Basal levels 9.81 6.8–12.2  
 1 day 14.16 11.8–16.8 0.007 
 2 days 11.71 7.1–12.6 n.s. 
 7 days 11.93 9.1–13.5 n.s. 
Median value (pg/dl)95% CI (pg/dl)P (Mann-Whitney U test)
VEGF    
 Basal levels 745.00 654.80–986.26  
 1 day 602.49 424.06–753.25 0.019 
 2 days 556.84 358.3–640.71 0.001 
 7 days 556.88 442.49–684.28 0.03 
γ-IFN    
 Basal levels 12.00 11.25–18.65  
 1 day 21.28 18.43–28.65 0.003 
 2 days 11.53 11.70–18.39 n.s. 
 7 days 9.725 10.17–16.48 n.s. 
IL-6    
 Basal levels 9.81 6.8–12.2  
 1 day 14.16 11.8–16.8 0.007 
 2 days 11.71 7.1–12.6 n.s. 
 7 days 11.93 9.1–13.5 n.s. 
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