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Table 3

In vivo mRNA expression level and microvessel density after the therapy with angiogenesis inhibitor TNP-470 for nonestablished human TCC 253J B-V cells growing orthotopically in athymic nude mice

TherapymRNA expression indexaMicrovessel densityb
bFGFVEGFIL-8MMP-9MMP-2E-cadherin(per 200 ×/field)
CTRL (ethanol in arabic gum/saline) daily 100 100 100 100 100 100 108 ± 24 
TNP-470 (15 mg/kg) daily 59c 96 99 64c 96 106 55 ± 11c 
TNP-470 (35 mg/kg) daily 56c 96 98 62c 95 108 53 ± 10c 
TNP-470 (105 mg/kg) daily 56c 94 99 54c 94 106 46 ± 9c 
TNP-470 (35 mg/kg) 3 times per week 85 100 101 82 103 103 70 ± 15 
TNP-470 (105 mg/kg) weekly 96 101 100 99 106 105 93 ± 19 
TherapymRNA expression indexaMicrovessel densityb
bFGFVEGFIL-8MMP-9MMP-2E-cadherin(per 200 ×/field)
CTRL (ethanol in arabic gum/saline) daily 100 100 100 100 100 100 108 ± 24 
TNP-470 (15 mg/kg) daily 59c 96 99 64c 96 106 55 ± 11c 
TNP-470 (35 mg/kg) daily 56c 96 98 62c 95 108 53 ± 10c 
TNP-470 (105 mg/kg) daily 56c 94 99 54c 94 106 46 ± 9c 
TNP-470 (35 mg/kg) 3 times per week 85 100 101 82 103 103 70 ± 15 
TNP-470 (105 mg/kg) weekly 96 101 100 99 106 105 93 ± 19 
a

The intensity of the cytoplasmic color reaction was quantitated by an image analyzer and compared with the maximal intensity of poly(dT) color reaction in each sample. The results were presented as a number of each cell line compared with CTRL defined as 100.

b

Microvessel density was expressed as an average number of five highest areas identified within a single 200 ×/field.

c

P < 0.005 against CTRL (Mann-Whitney statistical comparison).

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