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Table 2

The single agent therapy of angiogenesis inhibitor TNP-470 for established human TCC 253J B-V cells growing orthotopically in athymic nude mice

TherapyTumorigenicityaLN metastasisb
IncidenceMedian bladder weight (Range) (mg)Incidence
Nontreated CTRL (n = 7) 7/7 241 (100–340) 3/7 
CTRL (10% ethanol in 5% arabic gum/saline (sci)) daily (n = 8) 8/8 440 (154–553) 7/8 
TNP-470 (15 mg/kg (sci)) daily (n = 8) 8/8 49 (27–101)c 0/8d 
TNP-470 (35 mg/kg (sci)) daily (n = 8) 8/8 45 (20–83)c 0/8d 
TNP-470 (105 mg/kg (sci)) daily (n = 6) 5/6 44 (21–55)c 0/6e 
TNP-470 (35 mg/kg (sci)) 3 times per week (n = 7) 7/7 156 (36–222)f 3/7 
TNP-470 (105 mg/kg (sci)) weekly (n = 7) 7/7 263 (214–428) 5/7 
TherapyTumorigenicityaLN metastasisb
IncidenceMedian bladder weight (Range) (mg)Incidence
Nontreated CTRL (n = 7) 7/7 241 (100–340) 3/7 
CTRL (10% ethanol in 5% arabic gum/saline (sci)) daily (n = 8) 8/8 440 (154–553) 7/8 
TNP-470 (15 mg/kg (sci)) daily (n = 8) 8/8 49 (27–101)c 0/8d 
TNP-470 (35 mg/kg (sci)) daily (n = 8) 8/8 45 (20–83)c 0/8d 
TNP-470 (105 mg/kg (sci)) daily (n = 6) 5/6 44 (21–55)c 0/6e 
TNP-470 (35 mg/kg (sci)) 3 times per week (n = 7) 7/7 156 (36–222)f 3/7 
TNP-470 (105 mg/kg (sci)) weekly (n = 7) 7/7 263 (214–428) 5/7 
a

Tumorigenicity (P, Mann-Whitney statistical comparison).

b

LN metastasis (P, χ2 test).

c

P < 0.001 against nontreated CTRL and CTRL, P < 0.005 against TNP-470 (35 mg/kg (sci)) 3 times per week, and P < 0.001 against TNP-470 (105 mg/kg (sci)) weekly.

d

P < 0.05 against nontreated CTRL, P < 0.001 against CTRL, P < 0.05 against TNP-470 (35 mg/kg (sci)) 3 times per week, and P < 0.005 against TNP-470 (105 mg/kg (sci)) weekly.

e

P < 0.005 against CTRL and P < 0.01 against TNP-470 (105 mg/kg (sci)) weekly.

f

P < 0.005 against CTRL.

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