The single agent therapy of angiogenesis inhibitor TNP-470 for established human TCC 253J B-V cells growing orthotopically in athymic nude mice
| Therapy . | Tumorigenicitya . | . | LN metastasisb . | |
|---|---|---|---|---|
| . | Incidence . | Median bladder weight (Range) (mg) . | Incidence . | |
| Nontreated CTRL (n = 7) | 7/7 | 241 (100–340) | 3/7 | |
| CTRL (10% ethanol in 5% arabic gum/saline (sci)) daily (n = 8) | 8/8 | 440 (154–553) | 7/8 | |
| TNP-470 (15 mg/kg (sci)) daily (n = 8) | 8/8 | 49 (27–101)c | 0/8d | |
| TNP-470 (35 mg/kg (sci)) daily (n = 8) | 8/8 | 45 (20–83)c | 0/8d | |
| TNP-470 (105 mg/kg (sci)) daily (n = 6) | 5/6 | 44 (21–55)c | 0/6e | |
| TNP-470 (35 mg/kg (sci)) 3 times per week (n = 7) | 7/7 | 156 (36–222)f | 3/7 | |
| TNP-470 (105 mg/kg (sci)) weekly (n = 7) | 7/7 | 263 (214–428) | 5/7 | |
| Therapy . | Tumorigenicitya . | . | LN metastasisb . | |
|---|---|---|---|---|
| . | Incidence . | Median bladder weight (Range) (mg) . | Incidence . | |
| Nontreated CTRL (n = 7) | 7/7 | 241 (100–340) | 3/7 | |
| CTRL (10% ethanol in 5% arabic gum/saline (sci)) daily (n = 8) | 8/8 | 440 (154–553) | 7/8 | |
| TNP-470 (15 mg/kg (sci)) daily (n = 8) | 8/8 | 49 (27–101)c | 0/8d | |
| TNP-470 (35 mg/kg (sci)) daily (n = 8) | 8/8 | 45 (20–83)c | 0/8d | |
| TNP-470 (105 mg/kg (sci)) daily (n = 6) | 5/6 | 44 (21–55)c | 0/6e | |
| TNP-470 (35 mg/kg (sci)) 3 times per week (n = 7) | 7/7 | 156 (36–222)f | 3/7 | |
| TNP-470 (105 mg/kg (sci)) weekly (n = 7) | 7/7 | 263 (214–428) | 5/7 | |
Tumorigenicity (P, Mann-Whitney statistical comparison).
LN metastasis (P, χ2 test).
P < 0.001 against nontreated CTRL and CTRL, P < 0.005 against TNP-470 (35 mg/kg (sci)) 3 times per week, and P < 0.001 against TNP-470 (105 mg/kg (sci)) weekly.
P < 0.05 against nontreated CTRL, P < 0.001 against CTRL, P < 0.05 against TNP-470 (35 mg/kg (sci)) 3 times per week, and P < 0.005 against TNP-470 (105 mg/kg (sci)) weekly.
P < 0.005 against CTRL and P < 0.01 against TNP-470 (105 mg/kg (sci)) weekly.
P < 0.005 against CTRL.