American Association for Cancer Research

Table 1

The single agent therapy of angiogenesis inhibitor TNP-470 for nonestablished human transitional cell carcinoma 253J B-V cells growing orthotopically in athymic nude mice

Therapy	Tumorigenicity^a			LN metastasis^b
Therapy		Incidence	Median bladder weight (Range) (mg)	Incidence
CTRL (10% ethanol in 5% arabic gum/saline (sci)) daily (n = 9)	9/9	147 (120–263)	4/9
TNP-470 (15 mg/kg (sci)) daily (n = 9)	8/9	37 (20–53)^c	0/9^d
TNP-470 (35 mg/kg (sci)) daily (n = 9)	9/9	38 (24–59)^c	0/9^d
TNP-470 (105 mg/kg (sci)) daily (n = 6)	4/6	35 (22–42)^c	0/6
TNP-470 (35 mg/kg (sci)) 3 times/week (n = 8)	8/8	68 (29–111)^e	0/8^d
TNP-470 (105 mg/kg (sci)) weekly (n = 9)	9/9	80 (38–210)^f	1/9

Therapy	Tumorigenicity^a			LN metastasis^b
Therapy		Incidence	Median bladder weight (Range) (mg)	Incidence
CTRL (10% ethanol in 5% arabic gum/saline (sci)) daily (n = 9)	9/9	147 (120–263)	4/9
TNP-470 (15 mg/kg (sci)) daily (n = 9)	8/9	37 (20–53)^c	0/9^d
TNP-470 (35 mg/kg (sci)) daily (n = 9)	9/9	38 (24–59)^c	0/9^d
TNP-470 (105 mg/kg (sci)) daily (n = 6)	4/6	35 (22–42)^c	0/6
TNP-470 (35 mg/kg (sci)) 3 times/week (n = 8)	8/8	68 (29–111)^e	0/8^d
TNP-470 (105 mg/kg (sci)) weekly (n = 9)	9/9	80 (38–210)^f	1/9

Tumorigenicity (P, Mann-Whitney statistical comparison).

LN metastasis (P, χ² test).

P < 0.001 against CTRL, P < 0.005 against TNP-470 (35 mg/kg (sci)) 3 times/week and TNP-470 (105 mg/kg (sci)) weekly.

P < 0.05 against CTRL.

P < 0.001 against CTRL.

P < 0.005 against CTRL.

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