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Table 1

The single agent therapy of angiogenesis inhibitor TNP-470 for nonestablished human transitional cell carcinoma 253J B-V cells growing orthotopically in athymic nude mice

TherapyTumorigenicityaLN metastasisb
IncidenceMedian bladder weight (Range) (mg)Incidence
CTRL (10% ethanol in 5% arabic gum/saline (sci)) daily (n = 9) 9/9 147 (120–263) 4/9 
TNP-470 (15 mg/kg (sci)) daily (n = 9) 8/9 37 (20–53)c 0/9d 
TNP-470 (35 mg/kg (sci)) daily (n = 9) 9/9 38 (24–59)c 0/9d 
TNP-470 (105 mg/kg (sci)) daily (n = 6) 4/6 35 (22–42)c 0/6 
TNP-470 (35 mg/kg (sci)) 3 times/week (n = 8) 8/8 68 (29–111)e 0/8d 
TNP-470 (105 mg/kg (sci)) weekly (n = 9) 9/9 80 (38–210)f 1/9 
TherapyTumorigenicityaLN metastasisb
IncidenceMedian bladder weight (Range) (mg)Incidence
CTRL (10% ethanol in 5% arabic gum/saline (sci)) daily (n = 9) 9/9 147 (120–263) 4/9 
TNP-470 (15 mg/kg (sci)) daily (n = 9) 8/9 37 (20–53)c 0/9d 
TNP-470 (35 mg/kg (sci)) daily (n = 9) 9/9 38 (24–59)c 0/9d 
TNP-470 (105 mg/kg (sci)) daily (n = 6) 4/6 35 (22–42)c 0/6 
TNP-470 (35 mg/kg (sci)) 3 times/week (n = 8) 8/8 68 (29–111)e 0/8d 
TNP-470 (105 mg/kg (sci)) weekly (n = 9) 9/9 80 (38–210)f 1/9 
a

Tumorigenicity (P, Mann-Whitney statistical comparison).

b

LN metastasis (P, χ2 test).

c

P < 0.001 against CTRL, P < 0.005 against TNP-470 (35 mg/kg (sci)) 3 times/week and TNP-470 (105 mg/kg (sci)) weekly.

d

P < 0.05 against CTRL.

e

P < 0.001 against CTRL.

f

P < 0.005 against CTRL.

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