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Therapeutic Research and Development

Translational studies that investigate molecular targets, lead compounds, and experimental therapies in a preclinical setting

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November 02 2021

8-Azaadenosine and 8-Chloroadenosine are not Selective Inhibitors of ADAR

Kyle A. Cottrell, Luisangely Soto-Torres et al.

The RNA editing enzyme ADAR is an attractive therapeutic target for multiple cancers. Through its deaminase activity, ADAR edits adenosine to inosine in double-stranded RNAs. Loss of ADAR in some cancer cell lines causes activation of the type I IFN pathway and the PKR translational repressor, leading to inhibition of ...

October 13 2021

HSP70 Inhibition Blocks Adaptive Resistance and Synergizes with MEK Inhibition for the Treatment of NRAS-Mutant Melanoma

Joshua L.D. Parris, Thibaut Barnoud et al.

NRAS-mutant melanoma is currently a challenge to treat. This is due to an absence of inhibitors directed against mutant NRAS, along with adaptive and acquired resistance of this tumor type to inhibitors in the MAPK pathway. Inhibitors to MEK have shown some promise for NRAS-mutant melanoma. In this work, we explored the ...

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Topics in Therapeutic Research and Development

Expand/Collapse Section ALTERNATIVE MEDICINE
Expand/Collapse Section BIOLOGICAL AGENTS & THERAPIES
- Antireceptors
- Antibody-drug conjugates
- Aptamers, ribozymes, or DNAzymes
- Antisense oligonucleotides
- Cell-based therapeutics
- Differentiation therapy
- Gene therapy
- Stem cell therapies
Expand/Collapse Section CHEMOTHERAPY
- Adjuvant chemotherapy
- Biochemical modulators of the therapeutic index
- Combination chemotherapy
- Differentiation therapy
- Novel drug delivery systems
Expand/Collapse Section DRUG MECHANISMS
- Cell cycle mechanisms of anticancer drug action
- Cellular responses to anticancer drugs
- Drug-mediated stimulation of cell death pathways
- p53 and anticancer drug action
- Modulation of DNA repair
Expand/Collapse Section DRUG RESISTANCE
- Biochemistry of membrane metabolism and transport
- Drug transport and metabolism
- Glutathione metabolism
- Non-transporter-based drug resistance
- Novel mechanisms
- Regulation of gene expression in drug resistance
- Reversal of drug resistance
- Transporter-based drug resistance
- Clinical drug resistance
Expand/Collapse Section DRUG TARGETS
- Cell surface receptor drug targets
- Oncoprotein & tumor suppressor drug targets
- Protein kinase & phosphatase drug targets
Expand/Collapse Section NANOPARTICLE AGENTS
Expand/Collapse Section PHARMACOLOGY
- Cellular pharmacology
- Molecular pharmacology
- Pharmacogenetics/pharmacogenomics
- Preclinical toxicology
- Pharmacokinetics and pharmacodynamics
- Biodistribution/toxicology
Expand/Collapse Section SMALL MOLECULE AGENTS
- Alkylating agents
- DNA-reactive agents
- Epigenetic-targeted agents
- Kinase inhibitors
- Phosphatase inhibitors
- HDAC & methyltransferase inhibitors
- Platinum complexes
- Proteasome inhibitors
- Retinoids
- Topoisomerase agents
- Tubulin agents
Expand/Collapse Section TRANSLATIONAL RESEARCH

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