Tumor Heterogeneity Collection

Editors of the AACR journals reviewed recently published content to identify hot topics across the entire portfolio. This publication focuses on tumor heterogeniety and highlights articles based on a number of key metrics, such as usage and citations. We hope that you enjoy this complimentary cross-journal collection.

• Multi-omic analysis of subtype evolution and heterogeneity in high-grade serous ovarian carcinoma
  Ludwig Geistlinger…Levi Waldron Cancer Research August 2020.
• Tumor Microenvironment Is Critical for the Maintenance of Cellular States Found in Primary Glioblastomas
  Allison R. Pine…Howard A. Fine Cancer Discovery April 2020.
• Cytotoxic Therapy–Induced Effects on Both Hematopoietic and Marrow Stromal Cells Promotes Therapy-Related Myeloid Neoplasms
  Angela Stoddart…Michelle M. Le Beau Blood Cancer Discovery April 2020.
• A TGFβ-Dependent Stromal Subset Underlies Immune Checkpoint Inhibitor Efficacy in DNA Mismatch Repair–Deficient/Microsatellite Instability-High Colorectal Cancer
  Eisei Endo…Koji Kono Molecular Cancer Research June 2020.
• The Outcome of Ex Vivo TIL Expansion Is Highly Influenced by Spatial Heterogeneity of the Tumor T-Cell Repertoire and Differences in Intrinsic In Vitro Growth Capacity between T-Cell Clones
  Isabel C. Poschke...Rienk Offringa Clinical Cancer Research April 2020.
• Single-Cell Analysis Reveals Fibroblast Clusters Linked to Immunotherapy Resistance in Cancer
  Yann Kieffer...Fatima Mechta-Grigoriou Cancer Discovery May 2020.
• Proteogenomics Uncovers a Vast Repertoire of Shared Tumor-Specific Antigens in Ovarian Cancer
  Qingchuan Zhao...Claude Perreault Cancer Immunology Research February 2020.
• Mutational Landscape and Patterns of Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia
  Esmé Waanders...Charles G. Mullighan Blood Cancer Discovery January 2020.