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Journal Articles

Loss of H3K27 Trimethylation Promotes Radiotherapy Resistance in Medulloblastoma and Induces an Actionable Vulnerability to BET Inhibition

Nishanth Gabriel, Kumaresh Balaji, Kay Jayachandran, Matthew Inkman, Jin Zhang, Sonika Dahiya, Michael Goldstein
Journal: Cancer Research
Cancer Res (2022) 82 (10): 2019–2030.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-0871
Published: 16 May 2022
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A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non–Small Cell Lung Cancer

Jieun Son, Jaebong Jang, Tyler S. Beyett, Yoonji Eum, Heidi M. Haikala, Alyssa Verano, Mika Lin, John M. Hatcher, Nicholas P. Kwiatkowski, Pinar Ö. Eser, Michael J. Poitras, Stephen Wang, Man Xu, Prafulla C. Gokhale, Michael D. Cameron, Michael J. Eck, Nathanael S. Gray, Pasi A. Jänne
Journal: Cancer Research
Cancer Res (2022) 82 (8): 1633–1645.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-2693
Published: 15 April 2022
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Preclinical In Vivo Validation of the RAD51 Test for Identification of Homologous Recombination-Deficient Tumors and Patient Stratification

Benedetta Pellegrino, Andrea Herencia-Ropero, Alba Llop-Guevara, Flaminia Pedretti, Alejandro Moles-Fernández, Cristina Viaplana, Guillermo Villacampa, Marta Guzmán, Olga Rodríguez, Judit Grueso, Jose Jiménez, Enrique J. Arenas, Andrea Degasperi, João M.L. Dias, Josep V. Forment, Mark J. O'Connor, Olivier Déas, Stefano Cairo, Yinghui Zhou, Antonino Musolino, Carlos Caldas, Serena Nik-Zainal, Robert B. Clarke, Paolo Nuciforo, Orland Díez, Xavier Serres-Créixams, Vicente Peg, Martín Espinosa-Bravo, Teresa Macarulla, Ana Oaknin, Joaquin Mateo, Joaquín Arribas, Rodrigo Dienstmann, Meritxell Bellet, Mafalda Oliveira, Cristina Saura, Sara Gutiérrez-Enríquez, Judith Balmaña, Violeta Serra
Journal: Cancer Research
Cancer Res (2022) 82 (8): 1646–1657.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-2409
Published: 15 April 2022
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Neoadjuvant Intratumoral Immunotherapy with TLR9 Activation and Anti-OX40 Antibody Eradicates Metastatic Cancer

Wan Xing Hong, Idit Sagiv-Barfi, Debra K. Czerwinski, Adrienne Sallets, Ronald Levy
Journal: Cancer Research
Cancer Res (2022) 82 (7): 1396–1408.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-1382
Published: 01 April 2022
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A Urinary Drug-Disposing Approach as an Alternative to Intravesical Chemotherapy for Treating Nonmuscle Invasive Bladder Cancer

Vanessa Bellat, Adam O. Michel, Charlene Thomas, Tracy Stokol, Benjamin B. Choi, Benedict Law
Journal: Cancer Research
Cancer Res (2022) 82 (7): 1409–1422.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-2897
Published: 01 April 2022
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PGC1α/β Expression Predicts Therapeutic Response to Oxidative Phosphorylation Inhibition in Ovarian Cancer

Carmen Ghilardi, Catarina Moreira-Barbosa, Laura Brunelli, Paola Ostano, Nicolò Panini, Monica Lupi, Alessia Anastasia, Fabio Fiordaliso, Monica Salio, Laura Formenti, Massimo Russo, Edoardo Arrigoni, Ferdinando Chiaradonna, Giovanna Chiorino, Giulio Draetta, Joseph R. Marszalek, Christopher P. Vellano, Roberta Pastorelli, MariaRosa Bani, Alessandra Decio, Raffaella Giavazzi
Journal: Cancer Research
Cancer Res (2022) 82 (7): 1423–1434.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-1223
Published: 01 April 2022
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Transient Inhibition of the JAK/STAT Pathway Prevents B-ALL Development in Genetically Predisposed Mice

Ana Casado-García, Marta Isidro-Hernández, Ninad Oak, Andrea Mayado, Christine Mann-Ran, Javier Raboso-Gallego, Silvia Alemán-Arteaga, Alexandra Buhles, Dario Sterker, Elena G. Sánchez, Jorge Martínez-Cano, Oscar Blanco, Alberto Orfao, Diego Alonso-López, Javier De Las Rivas, Susana Riesco, Pablo Prieto-Matos, África González-Murillo, Francisco Javier García Criado, María Begoña García Cenador, Thomas Radimerski, Manuel Ramírez-Orellana, César Cobaleda, Jun J. Yang, Carolina Vicente-Dueñas, Andreas Weiss, Kim E. Nichols, Isidro Sánchez-García
Journal: Cancer Research
Cancer Res (2022) 82 (6): 1098–1109.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-3386
Published: 15 March 2022
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ATR Inhibitor AZD6738 (Ceralasertib) Exerts Antitumor Activity as a Monotherapy and in Combination with Chemotherapy and the PARP Inhibitor Olaparib

Zena Wilson, Rajesh Odedra, Yann Wallez, Paul W.G. Wijnhoven, Adina M. Hughes, Joe Gerrard, Gemma N. Jones, Hannah Bargh-Dawson, Elaine Brown, Lucy A. Young, Mark J. O'Connor, Alan Lau
Journal: Cancer Research
Cancer Res (2022) 82 (6): 1140–1152.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-2997
Published: 15 March 2022
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CIC-Mediated Modulation of MAPK Signaling Opposes Receptor Tyrosine Kinase Inhibitor Response in Kinase-Addicted Sarcoma

Igor Odintsov, Michael V. Ortiz, Inna Khodos, Marissa S. Mattar, Allan J.W. Lui, Shinji Kohsaka, Elisa de Stanchina, Julia L. Glade Bender, Marc Ladanyi, Romel Somwar
Journal: Cancer Research
Cancer Res (2022) 82 (6): 1110–1127.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-1397
Published: 15 March 2022
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Development of Novel Aptamer-Based Targeted Chemotherapy for Bladder Cancer

Yao Wang, Yang Zhang, Peng-Chao Li, Jiajie Guo, Fan Huo, Jintao Yang, Ru Jia, Juan Wang, Qiju Huang, Dan Theodorescu, Hanyang Yu, Chao Yan
Journal: Cancer Research
Cancer Res (2022) 82 (6): 1128–1139.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-2691
Published: 15 March 2022
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ASO-Based PKM Splice-Switching Therapy Inhibits Hepatocellular Carcinoma Growth

Wai Kit Ma, Dillon M. Voss, Juergen Scharner, Ana S.H. Costa, Kuan-Ting Lin, Hyun Yong Jeon, John E. Wilkinson, Michaela Jackson, Frank Rigo, C. Frank Bennett, Adrian R. Krainer
Journal: Cancer Research
Cancer Res (2022) 82 (5): 900–915.
DOI: https://doi.org/10.1158/0008-5472.CAN-20-0948
Published: 03 March 2022
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p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade

David P. Molkentine, Jessica M. Molkentine, Kathleen A. Bridges, David R. Valdecanas, Annika Dhawan, Reshub Bahri, Andrew J. Hefner, Manish Kumar, Liangpeng Yang, Mohamed Abdelhakiem, Phillip M. Pifer, Vlad Sandulache, Aakash Sheth, Beth M. Beadle, Howard D. Thames, Kathryn A. Mason, Curtis R. Pickering, Raymond E. Meyn, Heath D. Skinner
Journal: Cancer Research
Cancer Res (2022) 82 (5): 916–928.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-2101
Published: 03 March 2022
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Integrated Molecular Characterization of Patient-Derived Models Reveals Therapeutic Strategies for Treating CIC-DUX4 Sarcoma

Marianna Carrabotta, Maria Antonella Laginestra, Giorgio Durante, Caterina Mancarella, Lorena Landuzzi, Alessandro Parra, Francesca Ruzzi, Lisa Toracchio, Alessandra De Feo, Veronica Giusti, Michela Pasello, Alberto Righi, Pier-Luigi Lollini, Emanuela Palmerini, Davide Maria Donati, Maria Cristina Manara, Katia Scotlandi
Journal: Cancer Research
Cancer Res (2022) 82 (4): 708–720.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-1222
Published: 15 February 2022
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JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer

Alec Paschalis, Jonathan Welti, Antje J. Neeb, Wei Yuan, Ines Figueiredo, Rita Pereira, Ana Ferreira, Ruth Riisnaes, Daniel Nava Rodrigues, Juan M. Jiménez-Vacas, Soojin Kim, Takuma Uo, Patrizio Di Micco, Anthony Tumber, Md. Saiful Islam, Marc A. Moesser, Martine Abboud, Akane Kawamura, Bora Gurel, Rossitza Christova, Veronica S. Gil, Lorenzo Buroni, Mateus Crespo, Susana Miranda, Maryou B. Lambros, Suzanne Carreira, Nina Tunariu, Andrea Alimonti, Bissan Al-Lazikani, Christopher J. Schofield, Stephen R. Plymate, Adam Sharp, Johann S. de Bono
Journal: Cancer Research
Cancer Res (2021) 81 (4): 1087–1100.
DOI: https://doi.org/10.1158/0008-5472.CAN-20-1807
Published: 15 February 2022
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Targeting Chemotherapy to Decondensed H3K27me3-Marked Chromatin of AML Cells Enhances Leukemia Suppression

Patrizia Porazzi, Svetlana Petruk, Luca Pagliaroli, Marco De Dominici, David Deming, II, Matthew V. Puccetti, Saul Kushinsky, Gaurav Kumar, Valentina Minieri, Elisa Barbieri, Sandra Deliard, Alexis Grande, Marco Trizzino, Alessandro Gardini, Eli Canaani, Neil Palmisiano, Pierluigi Porcu, Adam Ertel, Paolo Fortina, Christine M. Eischen, Alexander Mazo, Bruno Calabretta
Journal: Cancer Research
Cancer Res (2022) 82 (3): 458–471.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-1297
Published: 02 February 2022
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Inhibition of XPO1 Sensitizes Small Cell Lung Cancer to First- and Second-Line Chemotherapy

Alvaro Quintanal-Villalonga, Hirokazu Taniguchi, Yuan Hao, Andrew Chow, Yingqian A. Zhan, Shweta S. Chavan, Fathema Uddin, Viola Allaj, Parvathy Manoj, Nisargbhai S. Shah, Joseph M. Chan, Michael Offin, Metamia Ciampricotti, Jordana Ray-Kirton, Jacklynn Egger, Umesh Bhanot, Irina Linkov, Marina Asher, Michael H. Roehrl, Juan Qiu, Elisa de Stanchina, Travis J. Hollmann, Richard P. Koche, Triparna Sen, John T. Poirier, Charles M. Rudin
Journal: Cancer Research
Cancer Res (2022) 82 (3): 472–483.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-2964
Published: 02 February 2022
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Loss of FBXW7 Correlates with Increased IDH1 Expression in Glioma and Enhances IDH1-Mutant Cancer Cell Sensitivity to Radiation

Zhuo Yang, Nan Hu, Weiwei Wang, Weihua Hu, Shaolong Zhou, Jianxiang Shi, Minghe Li, Zhou Jing, Chao Chen, Xuyang Zhang, Ruyi Yang, Xudong Fu, Xinjun Wang
Journal: Cancer Research
Cancer Res (2022) 82 (3): 497–509.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-0384
Published: 02 February 2022
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Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors

Ellen M. Westerhout, Mohamed Hamdi, Peter Stroeken, Natalia E. Nowakowska, Arjan Lakeman, Jennemiek van Arkel, Nancy E. Hasselt, Boris Bleijlevens, Nurdan Akogul, Franciska Haneveld, Alvin Chan, Peter van Sluis, Danny Zwijnenburg, Richard Volckmann, Carel J.M. van Noesel, Igor Adameyko, Tim van Groningen, Jan Koster, Linda J. Valentijn, Johan van Nes, Rogier Versteeg
Journal: Cancer Research
Cancer Res (2022) 82 (3): 484–496.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-1621
Published: 02 February 2022
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T Cells Promote Metastasis by Regulating Extracellular Matrix Remodeling following Chemotherapy

Jozafina Haj-Shomaly, Avital Vorontsova, Tamar Barenholz-Cohen, Oshrat Levi-Galibov, Mahesh Devarasetty, Michael Timaner, Ziv Raviv, Tim J. Cooper, Shay Soker, Peleg Hasson, Daphne Weihs, Ruth Scherz-Shouval, Yuval Shaked
Journal: Cancer Research
Cancer Res (2022) 82 (2): 278–291.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-1012
Published: 18 January 2022
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Repurposing Ceritinib Induces DNA Damage and Enhances PARP Inhibitor Responses in High-Grade Serous Ovarian Carcinoma

Arun Kanakkanthara, Xiaonan Hou, Thomas L. Ekstrom, Valentina Zanfagnin, Amelia M. Huehls, Rebecca L. Kelly, Husheng Ding, Melissa C. Larson, George Vasmatzis, Ann L. Oberg, Scott H. Kaufmann, Aaron S. Mansfield, S. John Weroha, Larry M. Karnitz
Journal: Cancer Research
Cancer Res (2022) 82 (2): 307–319.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-0732
Published: 18 January 2022
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