Search Results | American Association for Cancer Research

Skip Nav Destination

1-20 of 866

2 3 4 5

Sort by

Sort Order Select

Journal Articles

Pharmacologic Activation of STING in the Bladder Induces Potent Antitumor Immunity in Non–Muscle Invasive Murine Bladder Cancer

Mol Cancer Ther OF1–OF11.

DOI: https://doi.org/10.1158/1535-7163.MCT-21-0780

Published: 18 May 2022

View article

Includes: Supplementary data

Journal Articles

Tucatinib has Selective Activity in HER2-Positive Cancers and Significant Combined Activity with Approved and Novel Breast Cancer–Targeted Therapies

Neil A. O'Brien, Holly K.T. Huang, Martina S.J. McDermott, Athena M. Madrid, Tong Luo, Raul Ayala, Shawnt Issakhanian, Ke Wei Gong, Ming Lu, Jun Zhang, Dennis J. Slamon

Mol Cancer Ther (2022) 21 (5): 751–761.

DOI: https://doi.org/10.1158/1535-7163.MCT-21-0847

Published: 04 May 2022

View article

Includes: Supplementary data

Journal Articles

Inhibition of Oxidized Nucleotide Sanitation By TH1579 and Conventional Chemotherapy Cooperatively Enhance Oxidative DNA Damage and Survival in AML

Anders Centio, Montserrat Estruch, Kristian Reckzeh, Kumar Sanjiv, Camilla Vittori, Sophia Engelhard, Ulrika Warpman Berglund, Thomas Helleday, Kim Theilgaard-Mönch

Mol Cancer Ther (2022) 21 (5): 703–714.

DOI: https://doi.org/10.1158/1535-7163.MCT-21-0185

Published: 04 May 2022

View article

Includes: Supplementary data

Journal Articles

Adoptive Transfer of Anti-Nucleolin T Cells Combined with PD-L1 Inhibition against Triple-Negative Breast Cancer

Suyanee Thongchot, Niphat Jirapongwattana, Piriya Luangwattananun, Wannasiri Chiraphapphaiboon, Nisa Chuangchot, Doonyapat Sa-nguanraksa, Pornchai O-Charoenrat, Peti Thuwajit, Pa-thai Yenchitsomanus, Chanitra Thuwajit

Mol Cancer Ther (2022) 21 (5): 727–739.

DOI: https://doi.org/10.1158/1535-7163.MCT-21-0823

Published: 04 May 2022

View article

Includes: Multimedia, Supplementary data

Journal Articles

Dual Fluorescence Isogenic Synthetic Lethal Kinase Screen and High-Content Secondary Screening for MUC16/CA125-Selective Agents

Thapi D. Rao, Mengyao Xu, Stephanie Eng, Guangli Yang, Robin Manson, Nestor Rosales, Raj Kumar, Irva E. Veillard, Qin Zhou, Alexia Iasonos, Ouathek Ouerfelli, Hakim Djaballah, David R. Spriggs, Oladapo O. Yeku

Mol Cancer Ther (2022) 21 (5): 775–785.

DOI: https://doi.org/10.1158/1535-7163.MCT-21-0572

Published: 04 May 2022

View article

Includes: Supplementary data

Journal Articles

Diaminobutoxy-substituted Isoflavonoid (DBI-1) Enhances the Therapeutic Efficacy of GLUT1 Inhibitor BAY-876 by Modulating Metabolic Pathways in Colon Cancer Cells

Lichao Guo, Wen Zhang, Yanqi Xie, Xi Chen, Emma E. Olmstead, Mengqiang Lian, Baochen Zhang, Yekaterina Y. Zaytseva, B. Mark Evers, H. Peter Spielmann, Xifu Liu, David S. Watt, Chunming Liu

Mol Cancer Ther (2022) 21 (5): 740–750.

DOI: https://doi.org/10.1158/1535-7163.MCT-21-0925

Published: 04 May 2022

View article

Includes: Supplementary data

Journal Articles

A Preclinical Study to Repurpose Spironolactone for Enhancing Chemotherapy Response in Bladder Cancer

Dongbo Xu, Qiang Cao, Li Wang, Jianmin Wang, Bo Xu, Kristopher Attwood, Lei Wei, Yue Wu, Gary J. Smith, Eriko Katsuta, Kazuaki Takabe, Gurkamal Chatta, Khurshid A. Guru, David W. Goodrich, Qiang J. Li

Mol Cancer Ther (2022) 21 (5): 786–798.

DOI: https://doi.org/10.1158/1535-7163.MCT-21-0613

Published: 04 May 2022

View article

Includes: Supplementary data

Journal Articles

Therapeutic Targeting of EZH2 and BET BRD4 in Pediatric Rhabdoid Tumors

Yukitomo Ishi, Yongzhan Zhang, Ali Zhang, Takahiro Sasaki, Andrea Piunti, Amreena Suri, Jun Watanabe, Kouki Abe, Xingyao He, Hiroaki Katagi, Pankaj Bhalla, Manabu Natsumeda, Lihua Zou, Ali Shilatifard, Rintaro Hashizume

Mol Cancer Ther (2022) 21 (5): 715–726.

DOI: https://doi.org/10.1158/1535-7163.MCT-21-0646

Published: 04 May 2022

View article

Includes: Supplementary data

Journal Articles

Concurrent Inhibition of ERK and Farnesyltransferase Suppresses the Growth of HRAS Mutant Head and Neck Squamous Cell Carcinoma

Sehrish Javaid, Antje Schaefer, Craig M. Goodwin, Victoria V. Nguyen, Frances L. Massey, Mariaelena Pierobon, Da'Jhnae Gambrell-Sanders, Andrew M. Waters, Kathryn N. Lambert, J. Nathaniel Diehl, G. Aaron Hobbs, Kris C. Wood, Emanuel F. Petricoin, III, Channing J. Der, Adrienne D. Cox

Mol Cancer Ther (2022) 21 (5): 762–774.

DOI: https://doi.org/10.1158/1535-7163.MCT-21-0142

Published: 04 May 2022

View article

Includes: Supplementary data

Journal Articles

Acquired Resistance to EZH2 Inhibitor GSK343 Promotes the Differentiation of Human DLBCL Cell Lines toward an ABC-Like Phenotype

Samuel E.J. Preston, Audrey Emond, Filippa Pettersson, Daphné Dupéré-Richer, Madelyn Jean Abraham, Alberto Riva, Mena Kinal, Ryan N. Rys, Nathalie A. Johnson, Koren K. Mann, Sonia V. del Rincón, Jonathan D. Licht, Wilson H. Miller, Jr

Mol Cancer Ther (2022) 21 (4): 511–521.

DOI: https://doi.org/10.1158/1535-7163.MCT-21-0216

Published: 01 April 2022

View article

Includes: Supplementary data

Journal Articles

The DNA-PK Inhibitor AZD7648 Sensitizes Patient-Derived Ovarian Cancer Xenografts to Pegylated Liposomal Doxorubicin and Olaparib Preventing Abdominal Metastases

Alessia Anastasia, Giulia Dellavedova, Antonio Ramos-Montoya, Neil James, Giovanna Chiorino, Massimo Russo, Hana Baakza, Joanne Wilson, Carmen Ghilardi, Elaine B. Cadogan, Raffaella Giavazzi, Maria Rosa Bani

Mol Cancer Ther (2022) 21 (4): 555–567.

DOI: https://doi.org/10.1158/1535-7163.MCT-21-0420

Published: 01 April 2022

View article

Includes: Supplementary data

Journal Articles

Small-Molecule MMRi62 Induces Ferroptosis and Inhibits Metastasis in Pancreatic Cancer via Degradation of Ferritin Heavy Chain and Mutant p53

Junhui Li, Rati Lama, Samuel L. Galster, Joseph R. Inigo, Jin Wu, Dhyan Chandra, Sherry R. Chemler, Xinjiang Wang

Mol Cancer Ther (2022) 21 (4): 535–545.

DOI: https://doi.org/10.1158/1535-7163.MCT-21-0728

Published: 01 April 2022

View article

Includes: Supplementary data

Journal Articles

PhAc-ALGP-Dox, a Novel Anticancer Prodrug with Targeted Activation and Improved Therapeutic Index

Andrea Casazza, Lawrence Van Helleputte, Britt Van Renterghem, Peter Pokreisz, Natalie De Geest, Marzia De Petrini, Tom Janssens, Marijke Pellens, Marjan Diricx, Carla Riera-Domingo, Agnieszka Wozniak, Massimiliano Mazzone, Patrick Schöffski, Olivier Defert, Geert Reyns, Nele Kindt

Mol Cancer Ther (2022) 21 (4): 568–581.

DOI: https://doi.org/10.1158/1535-7163.MCT-21-0518

Published: 01 April 2022

View article

Includes: Supplementary data

Journal Articles

Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma

Pavlina Spiliopoulou, Sarah Spear, Hasan Mirza, Ian Garner, Lynn McGarry, Fabio Grundland-Freile, Zhao Cheng, Darren P. Ennis, Nayana Iyer, Sophie McNamara, Marina Natoli, Susan Mason, Karen Blyth, Peter D. Adams, Patricia Roxburgh, Matthew J. Fuchter, Bob Brown, Iain A. McNeish

Mol Cancer Ther (2022) 21 (4): 522–534.

DOI: https://doi.org/10.1158/1535-7163.MCT-21-0743

Published: 01 April 2022

View article

Includes: Supplementary data

Journal Articles

Critical Role for Cap-Independent c-MYC Translation in Progression of Multiple Myeloma

Yijiang Shi, Fumou Sun, Yan Cheng, Brent Holmes, Binod Dhakal, Joseph F. Gera, Siegfried Janz, Alan Lichtenstein

Mol Cancer Ther (2022) 21 (4): 502–510.

DOI: https://doi.org/10.1158/1535-7163.MCT-21-0016

Published: 01 April 2022

View article

Includes: Supplementary data

Journal Articles

A Prostate-Specific Membrane Antigen—Targeted Near-Infrared Conjugate for Identifying Pulmonary Squamous Cell Carcinoma during Resection

Gregory T. Kennedy, Feredun S. Azari, Elizabeth Bernstein, Bilal Nadeem, Ashley E. Chang, Alix Segil, Neil Sullivan, Isvita Marfatia, Azra Din, Charuhas Desphande, John C. Kucharczuk, Philip S. Low, Sunil Singhal

Mol Cancer Ther (2022) 21 (4): 546–554.

DOI: https://doi.org/10.1158/1535-7163.MCT-21-0821

Published: 01 April 2022

View article

Journal Articles

Targeting IKKε in Androgen-Independent Prostate Cancer Causes Phenotypic Senescence and Genomic Instability

Sophie Gilbert, Benjamin Péant, Nicolas Malaquin, Véronique Tu, Hubert Fleury, Kim Leclerc-Desaulniers, Francis Rodier, Anne-Marie Mes-Masson, Fred Saad

Mol Cancer Ther (2022) 21 (3): 407–418.

DOI: https://doi.org/10.1158/1535-7163.MCT-21-0519

Published: 04 March 2022

View article

Includes: Supplementary data

Journal Articles

Exploitation of Sulfated Glycosaminoglycan Status for Precision Medicine of Triplatin in Triple-Negative Breast Cancer

James D. Hampton, Erica J. Peterson, Samantha J. Katner, Tia H. Turner, Mohammad A. Alzubi, J. Chuck Harrell, Mikhail G. Dozmorov, Joseph B. McGee Turner, Pam J. Gigliotti, Vita Kraskauskiene, Mayuri Shende, Michael O. Idowu, Madhavi Puchalapalli, Bin Hu, Larisa Litovchick, Eriko Katsuta, Kazuaki Takabe, Nicholas P. Farrell, Jennifer E. Koblinski

Mol Cancer Ther (2022) 21 (2): 271–281.

DOI: https://doi.org/10.1158/1535-7163.MCT-20-0969

Published: 08 February 2022

View article

Includes: Supplementary data

Journal Articles

Cyclin-dependent Kinase 4/6 Inhibitor Palbociclib in Combination with Ralaniten Analogs for the Treatment of Androgen Receptor–positive Prostate and Breast Cancers

Amy H. Tien, Marianne D. Sadar

Mol Cancer Ther (2022) 21 (2): 294–309.

DOI: https://doi.org/10.1158/1535-7163.MCT-21-0411

Published: 08 February 2022

View article

Includes: Supplementary data

Journal Articles

Characterization of Novel α-Mangostin and Paeonol Derivatives With Cancer-Selective Cytotoxicity

Suneetha Nunna, Ying-Pei Huang, Mahdi Rasa, Anna Krepelova, Francesco Annunziata, Lisa Adam, Sandra Käppel, Ming-Hua Hsu, Francesco Neri

Mol Cancer Ther (2022) 21 (2): 257–270.

DOI: https://doi.org/10.1158/1535-7163.MCT-20-0787

Published: 08 February 2022

View article

Includes: Supplementary data

2 3 4 5

NARROW

Pharmacologic Activation of STING in the Bladder Induces Potent Antitumor Immunity in Non–Muscle Invasive Murine Bladder Cancer

Tucatinib has Selective Activity in HER2-Positive Cancers and Significant Combined Activity with Approved and Novel Breast Cancer–Targeted Therapies

Inhibition of Oxidized Nucleotide Sanitation By TH1579 and Conventional Chemotherapy Cooperatively Enhance Oxidative DNA Damage and Survival in AML

Adoptive Transfer of Anti-Nucleolin T Cells Combined with PD-L1 Inhibition against Triple-Negative Breast Cancer

Dual Fluorescence Isogenic Synthetic Lethal Kinase Screen and High-Content Secondary Screening for MUC16/CA125-Selective Agents

Diaminobutoxy-substituted Isoflavonoid (DBI-1) Enhances the Therapeutic Efficacy of GLUT1 Inhibitor BAY-876 by Modulating Metabolic Pathways in Colon Cancer Cells

A Preclinical Study to Repurpose Spironolactone for Enhancing Chemotherapy Response in Bladder Cancer

Therapeutic Targeting of EZH2 and BET BRD4 in Pediatric Rhabdoid Tumors

Concurrent Inhibition of ERK and Farnesyltransferase Suppresses the Growth of HRAS Mutant Head and Neck Squamous Cell Carcinoma

Acquired Resistance to EZH2 Inhibitor GSK343 Promotes the Differentiation of Human DLBCL Cell Lines toward an ABC-Like Phenotype

The DNA-PK Inhibitor AZD7648 Sensitizes Patient-Derived Ovarian Cancer Xenografts to Pegylated Liposomal Doxorubicin and Olaparib Preventing Abdominal Metastases

Small-Molecule MMRi62 Induces Ferroptosis and Inhibits Metastasis in Pancreatic Cancer via Degradation of Ferritin Heavy Chain and Mutant p53

PhAc-ALGP-Dox, a Novel Anticancer Prodrug with Targeted Activation and Improved Therapeutic Index

Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma

Critical Role for Cap-Independent c-MYC Translation in Progression of Multiple Myeloma

A Prostate-Specific Membrane Antigen—Targeted Near-Infrared Conjugate for Identifying Pulmonary Squamous Cell Carcinoma during Resection

Targeting IKKε in Androgen-Independent Prostate Cancer Causes Phenotypic Senescence and Genomic Instability

Exploitation of Sulfated Glycosaminoglycan Status for Precision Medicine of Triplatin in Triple-Negative Breast Cancer

Cyclin-dependent Kinase 4/6 Inhibitor Palbociclib in Combination with Ralaniten Analogs for the Treatment of Androgen Receptor–positive Prostate and Breast Cancers

Characterization of Novel α-Mangostin and Paeonol Derivatives With Cancer-Selective Cytotoxicity

AACR Journals

AACR Journals

This Feature Is Available To Subscribers Only