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Journal Articles

CHD1 promotes sensitivity to Aurora kinase inhibitors by suppressing interaction of AURKA with its coactivator TPX2

Haoyan Li, Yin Wang, Kevin Lin, Varadha Balaji Venkadakrishnan, Martin Bakht, Wei Shi, Chenling Meng, Jie Zhang, Kaitlyn Tremble, Xin Liang, Jian H. Song, Xu Feng, Vivien Van, Pingna Deng, Jared K. Burks, Ana Aparicio, Khandan Keyomarsi, Junjie Chen, Yue Lu, Himisha Beltran, Di Zhao
Journal: Cancer Research
Cancer Res can.22.0631.
DOI: https://doi.org/10.1158/0008-5472.CAN-22-0631
Published: 30 June 2022
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NCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron-sulfur cluster proteins

Naiara Santana-Codina, Maria Quiles del Rey, Kevin S. Kapner, Huan Zhang, Ajami Gikandi, Callum Malcolm, Clara Poupault, Miljan Kuljanin, Kristen M. John, Douglas E. Biancur, Brandon Chen, Nupur K. Das, Kristen E. Lowder, Connor J. Hennessey, Wesley Huang, Annan Yang, Yatrik M. Shah, Jonathan A. Nowak, Andrew J. Aguirre, Joseph D. Mancias
Journal: Cancer Discovery
Cancer Discov candisc.0043.2022-1-10 21:36:20.420.
DOI: https://doi.org/10.1158/2159-8290.CD-22-0043
Published: 30 June 2022
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A therapeutically actionable pro-tumoral axis of cytokines involving interleukin-8, TNFa and IL-1B

Irene Olivera, Rebeca Sanz-Pamplona, Elixabet Bolanos, Inmaculada Rodriguez, Inaki Etxeberria, Assunta Cirella, Josune Egea, Saray Garasa, Itziar Migueliz, Inaki Eguren-Santamaria, Miguel F. Sanmamed, Javier Glez-Vaz, Arantza Azpilikueta, Maite Alvarez, Maria C. Ochoa, Beatrice Malacrida, David Propper, Carlos E. de Andrea, Pedro Berraondo, Frances R. Balkwill, Alvaro Teijeira, Ignacio Melero
Journal: Cancer Discovery
Cancer Discov cd.21.1115.
DOI: https://doi.org/10.1158/2159-8290.CD-21-1115
Published: 30 June 2022
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Alpelisib monotherapy for PI3K-altered, pre-treated advanced breast cancer: a phase 2 study

Peter Savas, Louisa L. Lo, Stephen J. Luen, Elizabeth F. Blackley, Jason Callahan, Kate Moodie, Courtney T. van Geelen, Yi-An Ko, Chen-Fang Weng, Lironne Wein, Maria Joao Silva, Andjelija Zivanovic Bujak, Miriam M. Yeung, Sarah Ftouni, Rodney J. Hicks, Prudence A. Francis, Chee Khoon Lee, Sarah-Jane Dawson, Sherene Loi
Journal: Cancer Discovery
Cancer Discov cd.21.1696.
DOI: https://doi.org/10.1158/2159-8290.CD-21-1696
Published: 30 June 2022
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Coordinated transcriptional and catabolic programs support iron dependent adaptation to RAS-MAPK pathway inhibition in pancreatic cancer

Mirunalini Ravichandran, Jingjie Hu, Charles Cai, Nathan P. Ward, Anthony Venida, Callum Foakes, Miljan Kuljanin, Annan Yang, Connor J. Hennessey, Yang Yang, Brandon R. Desousa, Gilles Rademaker, Annelot A.L. Staes, Zeynep Cakir, Isha H. Jain, Andrew J. Aguirre, Joseph D. Mancias, Yin Shen, Gina M. DeNicola, Rushika M. Perera
Journal: Cancer Discovery
Cancer Discov cd.22.0044.
DOI: https://doi.org/10.1158/2159-8290.CD-22-0044
Published: 30 June 2022
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Systemic and oligo-acquired resistance to PD-(L)1 blockade in lung cancer

Adam J. Schoenfeld, Hira A. Rizvi, Danish Memon, Narek Shaverdian, Matthew J. Bott, Jennifer L. Sauter, Chiaojung Jillian Tsai, Jayon Lihm, David Hoyos, Andrew J. Plodkowski, Rocio Perez-Johnston, Peter Sawan, Jacklynn V. Egger, Benjamin D. Greenbaum, Andreas Rimner, Gregory J. Riely, Charles M. Rudin, Valerie W. Rusch, Daniel R. Gomez, Matthew D. Hellmann
Journal: Clinical Cancer Research
Clin Cancer Res clincanres.0657.2022.
DOI: https://doi.org/10.1158/1078-0432.CCR-22-0657
Published: 29 June 2022
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Superkine IL-2 and IL-33 Armored CAR T Cells Reshape the Tumor Microenvironment and Reduce Growth of Multiple Solid Tumors

Rachel A. Brog, Shannon L. Ferry, Courtney T. Schiebout, Cameron M. Messier, W. James Cook, Leena Abdullah, Jia Zou, Prathna Kumar, Charles L. Sentman, H. Robert Frost, Yina H. Huang
Journal: Cancer Immunology Research
Cancer Immunol Res OF1–OF16.
DOI: https://doi.org/10.1158/2326-6066.CIR-21-0536
Published: 29 June 2022
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Underutilization of Guideline-Recommended Mismatch Repair/Microsatellite Instability Biomarker Testing in Advanced Colorectal Cancer

David J. Papke, Neal I. Lindeman, Deborah Schrag, J. Bryan. Iorgulescu
Journal: Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiol Biomarkers Prev epi.22.0279.
DOI: https://doi.org/10.1158/1055-9965.EPI-22-0279
Published: 29 June 2022
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Post-diagnostic Inflammatory, Hyperinsulinemic, and Insulin Resistant Diets and Lifestyles and the Risk of Prostate Cancer Progression and Mortality

Crystal S. Langlais, Rebecca E. Graff, Erin L. Van Blarigan, Stacey A. Kenfield, John Neuhaus, Fred K. Tabung, Janet E. Cowan, Jeanette M. Broering, Peter Carroll, June M. Chan
Journal: Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiol Biomarkers Prev epi.22.0147.
DOI: https://doi.org/10.1158/1055-9965.EPI-22-0147
Published: 29 June 2022
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Caspase-3-induced activation of SREBP2 drives drug resistance via promotion of cholesterol biosynthesis in hepatocellular carcinoma

Etienne H. Mok, Carmen Oi-Ning Leung, Lei Zhou, Martina Mang Leng Lei, Hoi Wing Leung, Man Tong, Tin Lok Wong, Eunice Y. Lau, Irene Oi-Lin Ng, Jin Ding, Jing-Ping Yun, Jun Yu, Hui Lian Zhu, Chi Ho Lin, Dan Lindholm, Kit Sum Leung, Jonathan D. Cybulski, David M. Baker, Stephanie Ma, Terence K. Lee
Journal: Cancer Research
Cancer Res canres.2934.2021.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-2934
Published: 29 June 2022
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Squalene epoxidase metabolic dependency is a targetable vulnerability in castration-resistant prostate cancer

Xun Shangguan, Zehua Ma, Minghao Yu, Jie Ding, Wei Xue, Jun Qi
Journal: Cancer Research
Cancer Res canres.3822.2021.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-3822
Published: 29 June 2022
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Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian Cancer

Chang-Suk Chae, Tito A. Sandoval, Sung-Min Hwang, Eun Sil Park, Paolo Giovanelli, Deepika Awasthi, Camilla Salvagno, Alexander Emmanuelli, Chen Tan, Vidyanath Chaudhary, Julia Casado, Andrew V. Kossenkov, Minkyung Song, Franck J. Barrat, Kevin Holcomb, E. Alfonso Romero-Sandoval, Dmitriy Zamarin, David Pépin, Alan D. D'Andrea, Anniina Färkkilä, Juan R. Cubillos-Ruiz
Journal: Cancer Discovery
Cancer Discov OF1–OF18.
DOI: https://doi.org/10.1158/2159-8290.CD-21-1181
Published: 29 June 2022
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RNA helicase DDX24 stabilizes LAMB1 to promote hepatocellular carcinoma progression

Hong Shan, Tianze Liu, Hairun Gan, Simeng He, Jia Deng, Xinyan Hu, Luting Li, Li Cai, JianZhong He, Haoyu Long, Jianxun Cai, Hanjie Li, Qianqian Zhang, Lijie Wang, Fangbin Chen, Yuming Chen, Haopei Zhang, Jian Li, Lukun Yang, Ye Liu, Jianhua Yang, Dong-Ming Kuang, Pengfei Pang, Huanhuan He
Journal: Cancer Research
Cancer Res canres.3748.2021.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-3748
Published: 28 June 2022
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Extracellular vesicles may predict response to radioembolization and sorafenib treatment in advanced hepatocellular carcinoma

Timothy Wai Ho Shuen, Marianna Alunni-Fabbroni, Elif Öcal, Peter Malfertheiner, Moritz Wildgruber, Regina Schinner, Maciej Pech, Julia Benckert, Bruno Sangro, Christiane Kuhl, Antonio Gasbarrini, Pierce Kah Hoe Chow, Han Chong Toh, Jens Ricke
Journal: Clinical Cancer Research
Clin Cancer Res clincanres.0569.2022.
DOI: https://doi.org/10.1158/1078-0432.CCR-22-0569
Published: 28 June 2022
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Drug-induced epigenomic plasticity reprograms circadian rhythm regulation to drive prostate cancer towards androgen-independence

Simon Linder, Marlous Hoogstraat, Suzan Stelloo, Nils Eickhoff, Karianne Schuurman, Hilda de Barros, Maartje Alkemade, Elise M. Bekers, Tesa M. Severson, Joyce Sanders, Chia-Chi Flora Huang, Tunc Morova, Umut Berkay. Altintas, Liesbeth Hoekman, Yongsoo Kim, Sylvan C. Baca, Martin Sjostrom, Anniek Zaalberg, Dorine C. Hintzen, Jeroen de Jong, Roelof J.C. Kluin, Iris de Rink, Claudia Giambartolomei, Ji-Heui Seo, Bogdan Pasaniuc, Maarten Altelaar, Rene H. Medema, Felix Y. Feng, Amina Zoubeidi, Matthew L. Freedman, Lodewyk F.A. Wessels, Lisa M. Butler, Nathan A. Lack, Henk van der Poel, Andries M. Bergman, Wilbert Zwart
Journal: Cancer Discovery
Cancer Discov candisc.0576.2021-5-3 12:14:47.513.
DOI: https://doi.org/10.1158/2159-8290.CD-21-0576
Published: 27 June 2022
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A Targetable Myeloid Inflammatory State Governs Disease Recurrence in Clear Cell Renal Cell Carcinoma

Phillip M. Rappold, Lynda Vuong, Josef Leibold, Nicholas H. Chakiryan, Michael Curry, Fengshen Kuo, Erich Sabio, Hui Jiang, Briana G. Nixon, Ming Liu, Anders E. Berglund, Andrew W. Silagy, Ankur Mascareno, Mahdi Golkaram, Mahtab Marker, Albert Reising, Alexander Savchenko, John M. Millholland, Ying-Bei Chen, Paul Russo, Jonathan Coleman, Ed Reznik, Brandon J. Manley, Irina Ostrovnaya, Vladimir Makarov, Renzo G. DiNatale, Kyle A. Blum, Xiaoxiao Ma, Diego Chowell, Ming O. Li, David B. Solit, Scott W. Lowe, Timothy A. Chan, Robert J. Motzer, Martin H. Voss, A. Ari Hakimi
Journal: Cancer Discovery
Cancer Discov candisc.0925.2021.
DOI: https://doi.org/10.1158/2159-8290.CD-21-0925
Published: 27 June 2022
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Regulatory programs of B-cell activation and germinal center reaction allow B-ALL escape from CD19 CAR T-cell therapy

Nam Gyu Im, Amy Guillaumet-Adkins, Megha Wal, Anna J. Rogers, Julia Frede, Claire C. Havig, Jing Yang, Praveen Anand, Sarah K. Stegmann, Johannes M. Waldschmidt, Noori Sotudeh, Leili Niu, Jordan Voisine, Michal R. Schweiger, Clemens Grassberger, Jens G. Lohr, Birgit Knoechel
Journal: Cancer Immunology Research
Cancer Immunol Res canimm.0626.2021.
DOI: https://doi.org/10.1158/2326-6066.CIR-21-0626
Published: 27 June 2022
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Intravesical VAX014 Synergizes with PD-L1 Blockade to Enhance Local and Systemic Control of Bladder Cancer

Shingo Tsuji, Katherine Reil, Kinsey Nelson, Veronica H. Proclivo, Kathleen L. McGuire, Matthew J. Giacalone
Journal: Cancer Immunology Research
Cancer Immunol Res OF1–OF18.
DOI: https://doi.org/10.1158/2326-6066.CIR-21-0879
Published: 24 June 2022
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Adoptive Cellular Therapy with Autologous Tumor-Infiltrating Lymphocytes and T-cell Receptor–Engineered T Cells Targeting Common p53 Neoantigens in Human Solid Tumors

Sanghyun P. Kim, Nolan R. Vale, Nikolaos Zacharakis, Sri Krishna, Zhiya Yu, Billel Gasmi, Jared J. Gartner, Sivasish Sindiri, Parisa Malekzadeh, Drew C. Deniger, Frank J. Lowery, Maria R. Parkhurst, Lien T. Ngo, Satyajit Ray, Yong F. Li, Victoria Hill, Maria Florentin, Robert V. Masi, Biman C. Paria, Noam Levin, Alakesh Bera, Elizabeth A. Hedges, Agnes Choi, Praveen D. Chatani, Anup Y. Parikh, Shoshana Levi, Samantha Seitter, Yong-Chen Lu, Zhili Zheng, Todd D. Prickett, Li Jia, Jonathan M. Hernandez, Chuong D. Hoang, Paul F. Robbins, Stephanie L. Goff, Richard M. Sherry, James C. Yang, Steven A. Rosenberg
Journal: Cancer Immunology Research
Cancer Immunol Res OF1–OF15.
DOI: https://doi.org/10.1158/2326-6066.CIR-22-0040
Published: 24 June 2022
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Genomic Profiling of Bronchoalveolar Lavage Fluid in Lung Cancer

Viswam S. Nair, Angela B. Hui, Jacob J. Chabon, Mohammad Shahrokh Esfahani, Henning Stehr, Barzin Y. Nabet, Li Zhou, Aadel A. Chaudhuri, Jalen A. Benson, Kelsey Ayers, Harmeet Bedi, Meghan C. Ramsey, Ryan Van Wert, Sanja Antic, Natalie Shaubie. Lui, Leah M. Backhus, Mark F. Berry, Arthur W. Sung, Pierre P. Massion, Joseph B. Shrager, Ash A. Alizadeh, Maximilian Diehn
Journal: Cancer Research
Cancer Res canres.0554.2022.
DOI: https://doi.org/10.1158/0008-5472.CAN-22-0554
Published: 24 June 2022
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