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Journal Articles

Development of Gene Expression–Based Score to Predict Sensitivity of Multiple Myeloma Cells to DNA Methylation Inhibitors

Jérôme Moreaux, Thierry Rème, Wim Leonard, Jean-Luc Veyrune, Guilhem Requirand, Hartmut Goldschmidt, Dirk Hose, Bernard Klein

Mol Cancer Ther (2012) 11 (12): 2685–2692.

DOI: https://doi.org/10.1158/1535-7163.MCT-12-0721

Published: 09 December 2012

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Includes: Supplementary data

Journal Articles

Targeting the Inhibitor of Apoptosis Proteins as a Novel Therapeutic Strategy in Medulloblastoma

Joanna Keating, Maria Tsoli, Andrew R. Hallahan, Wendy J. Ingram, Michelle Haber, David S. Ziegler

Mol Cancer Ther (2012) 11 (12): 2654–2663.

DOI: https://doi.org/10.1158/1535-7163.MCT-12-0352

Published: 09 December 2012

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Includes: Supplementary data

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Inhibiting Aurora Kinases Reduces Tumor Growth and Suppresses Tumor Recurrence after Chemotherapy in Patient-Derived Triple-Negative Breast Cancer Xenografts

Angela Romanelli, Anderson Clark, Franck Assayag, Sophie Chateau-Joubert, Marie-France Poupon, Jean-Luc Servely, Jean-Jacques Fontaine, Xiaohong Liu, Edward Spooner, Samantha Goodstal, Patricia de Cremoux, Ivan Bièche, Didier Decaudin, Elisabetta Marangoni

Mol Cancer Ther (2012) 11 (12): 2693–2703.

DOI: https://doi.org/10.1158/1535-7163.MCT-12-0441-T

Published: 09 December 2012

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Includes: Supplementary data

Journal Articles

Targeting KRAS-Mutant Non–Small Cell Lung Cancer with the Hsp90 Inhibitor Ganetespib

Jaime Acquaviva, Donald L. Smith, Jim Sang, Julie C. Friedland, Suqin He, Manuel Sequeira, Chaohua Zhang, Yumiko Wada, David A. Proia

Mol Cancer Ther (2012) 11 (12): 2633–2643.

DOI: https://doi.org/10.1158/1535-7163.MCT-12-0615

Published: 09 December 2012

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Includes: Supplementary data

Journal Articles

Bispecific and Trispecific Killer Cell Engagers Directly Activate Human NK Cells through CD16 Signaling and Induce Cytotoxicity and Cytokine Production

Michelle K. Gleason, Michael R. Verneris, Deborah A. Todhunter, Bin Zhang, Valarie McCullar, Sophia X. Zhou, Angela Panoskaltsis-Mortari, Louis M. Weiner, Daniel A. Vallera, Jeffrey S. Miller

Mol Cancer Ther (2012) 11 (12): 2674–2684.

DOI: https://doi.org/10.1158/1535-7163.MCT-12-0692

Published: 09 December 2012

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Journal Articles

Regression of Human Prostate Cancer Xenografts in Mice by AMG 212/BAY2010112, a Novel PSMA/CD3-Bispecific BiTE Antibody Cross-Reactive with Non-Human Primate Antigens

Matthias Friedrich, Tobias Raum, Ralf Lutterbuese, Markus Voelkel, Petra Deegen, Doris Rau, Roman Kischel, Patrick Hoffmann, Christian Brandl, Joachim Schuhmacher, Peter Mueller, Ricarda Finnern, Melanie Fuergut, Dieter Zopf, Jerry W. Slootstra, Patrick A. Baeuerle, Benno Rattel, Peter Kufer

Mol Cancer Ther (2012) 11 (12): 2664–2673.

DOI: https://doi.org/10.1158/1535-7163.MCT-12-0042

Published: 09 December 2012

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BMS-754807, a Small-Molecule Inhibitor of Insulin-like Growth Factor-1 Receptor/Insulin Receptor, Enhances Gemcitabine Response in Pancreatic Cancer

Niranjan Awasthi, Changhua Zhang, Winston Ruan, Margaret A. Schwarz, Roderich E. Schwarz

Mol Cancer Ther (2012) 11 (12): 2644–2653.

DOI: https://doi.org/10.1158/1535-7163.MCT-12-0447

Published: 09 December 2012

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Includes: Supplementary data

Journal Articles

Selective Targeting of Interferon γ to Stromal Fibroblasts and Pericytes as a Novel Therapeutic Approach to Inhibit Angiogenesis and Tumor Growth

Ruchi Bansal, Tushar Tomar, Arne Östman, Klaas Poelstra, Jai Prakash

Mol Cancer Ther (2012) 11 (11): 2419–2428.

DOI: https://doi.org/10.1158/1535-7163.MCT-11-0758

Published: 08 November 2012

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Includes: Supplementary data

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O(6)-Methylguanine-DNA Methyltransferase Is a Novel Negative Effector of Invasion in Glioblastoma Multiforme

Manik Chahal, Bassam Abdulkarim, Yaoxian Xu, Marie-Christine Guiot, Jacob C. Easaw, Nicolas Stifani, Siham Sabri

Mol Cancer Ther (2012) 11 (11): 2440–2450.

DOI: https://doi.org/10.1158/1535-7163.MCT-11-0977

Published: 08 November 2012

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Includes: Multimedia, Supplementary data

Journal Articles

Perillyl Alcohol for the Treatment of Temozolomide-Resistant Gliomas

Hee-Yeon Cho, Weijun Wang, Niyati Jhaveri, Shering Torres, Joshua Tseng, Michelle N. Leong, David Jungpa Lee, Amir Goldkorn, Tong Xu, Nicos A. Petasis, Stan G. Louie, Axel H. Schönthal, Florence M. Hofman, Thomas C. Chen

Mol Cancer Ther (2012) 11 (11): 2462–2472.

DOI: https://doi.org/10.1158/1535-7163.MCT-12-0321

Published: 08 November 2012

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Includes: Supplementary data

Journal Articles

Inhibition of TGF-β Enhances the In Vivo Antitumor Efficacy of EGF Receptor–Targeted Therapy

Atul Bedi, Xiaofei Chang, Kimberly Noonan, Vui Pham, Rishi Bedi, Elana J. Fertig, Michael Considine, Joseph A. Califano, Ivan Borrello, Christine H. Chung, David Sidransky, Rajani Ravi

Mol Cancer Ther (2012) 11 (11): 2429–2439.

DOI: https://doi.org/10.1158/1535-7163.MCT-12-0101-T

Published: 08 November 2012

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Includes: Supplementary data

Journal Articles

Synthetic Lethal Screening with Small-Molecule Inhibitors Provides a Pathway to Rational Combination Therapies for Melanoma

Devin G. Roller, Mark Axelrod, Brian J. Capaldo, Karin Jensen, Aaron Mackey, Michael J. Weber, Daniel Gioeli

Mol Cancer Ther (2012) 11 (11): 2505–2515.

DOI: https://doi.org/10.1158/1535-7163.MCT-12-0461

Published: 08 November 2012

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Includes: Supplementary data

Journal Articles

Humanization of an Anti-CCR4 Antibody That Kills Cutaneous T-Cell Lymphoma Cells and Abrogates Suppression by T-Regulatory Cells

De-Kuan Chang, Jianhua Sui, Shusheng Geng, Asli Muvaffak, Mei Bai, Robert C. Fuhlbrigge, Agnes Lo, Anuradha Yammanuru, Luke Hubbard, Jared Sheehan, James J. Campbell, Quan Zhu, Thomas S. Kupper, Wayne A. Marasco

Mol Cancer Ther (2012) 11 (11): 2451–2461.

DOI: https://doi.org/10.1158/1535-7163.MCT-12-0278

Published: 08 November 2012

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Includes: Supplementary data

Journal Articles

A Locked, Dimeric CXCL12 Variant Effectively Inhibits Pulmonary Metastasis of CXCR4-Expressing Melanoma Cells Due to Enhanced Serum Stability

Tomonori Takekoshi, Joshua J. Ziarek, Brian F. Volkman, Sam T. Hwang

Mol Cancer Ther (2012) 11 (11): 2516–2525.

DOI: https://doi.org/10.1158/1535-7163.MCT-12-0494

Published: 08 November 2012

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Includes: Supplementary data

Journal Articles

Mechanistic Basis for Overcoming Platinum Resistance Using Copper Chelating Agents

Zheng D. Liang, Yan Long, Wen-Bin Tsai, Siqing Fu, Razelle Kurzrock, Mihai Gagea-Iurascu, Fan Zhang, Helen H.W. Chen, Bryan T. Hennessy, Gordon B. Mills, Niramol Savaraj, Macus Tien Kuo

Mol Cancer Ther (2012) 11 (11): 2483–2494.

DOI: https://doi.org/10.1158/1535-7163.MCT-12-0580

Published: 08 November 2012

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Includes: Supplementary data

Journal Articles

Stromal Platelet-Derived Growth Factor Receptor α (PDGFRα) Provides a Therapeutic Target Independent of Tumor Cell PDGFRα Expression in Lung Cancer Xenografts

David E. Gerber, Puja Gupta, Michael T. Dellinger, Jason E. Toombs, Michael Peyton, Inga Duignan, Jennifer Malaby, Timothy Bailey, Colleen Burns, Rolf A. Brekken, Nick Loizos

Mol Cancer Ther (2012) 11 (11): 2473–2482.

DOI: https://doi.org/10.1158/1535-7163.MCT-12-0431

Published: 08 November 2012

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Includes: Supplementary data

Journal Articles

8-Amino-Adenosine Activates p53-Independent Cell Death of Metastatic Breast Cancers

Alla Polotskaia, Sandy Hoffman, Nancy L. Krett, Mala Shanmugam, Steven T. Rosen, Jill Bargonetti

Mol Cancer Ther (2012) 11 (11): 2495–2504.

DOI: https://doi.org/10.1158/1535-7163.MCT-12-0085

Published: 08 November 2012

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Journal Articles

Antitumor Activity of Triolimus: A Novel Multidrug-Loaded Micelle Containing Paclitaxel, Rapamycin, and 17-AAG

Jason R. Hasenstein, Ho-Chul Shin, Kelsey Kasmerchak, Darya Buehler, Glen S. Kwon, Kevin R. Kozak

Mol Cancer Ther (2012) 11 (10): 2233–2242.

DOI: https://doi.org/10.1158/1535-7163.MCT-11-0987

Published: 09 October 2012

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Includes: Supplementary data

Journal Articles

Active Efflux of Dasatinib from the Brain Limits Efficacy against Murine Glioblastoma: Broad Implications for the Clinical Use of Molecularly Targeted Agents

Sagar Agarwal, Rajendar K. Mittapalli, David M. Zellmer, Jose L. Gallardo, Randy Donelson, Charlie Seiler, Stacy A. Decker, Karen S. SantaCruz, Jenny L. Pokorny, Jann N. Sarkaria, William F. Elmquist, John R. Ohlfest

Mol Cancer Ther (2012) 11 (10): 2183–2192.

DOI: https://doi.org/10.1158/1535-7163.MCT-12-0552

Published: 09 October 2012

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Includes: Supplementary data

Journal Articles

Garcinol Regulates EMT and Wnt Signaling Pathways In Vitro and In Vivo, Leading to Anticancer Activity against Breast Cancer Cells

Aamir Ahmad, Sanila H. Sarkar, Bassam Bitar, Shadan Ali, Amro Aboukameel, Seema Sethi, Yiwei Li, Bin Bao, Dejuan Kong, Sanjeev Banerjee, Subhash B. Padhye, Fazlul H. Sarkar

Mol Cancer Ther (2012) 11 (10): 2193–2201.

DOI: https://doi.org/10.1158/1535-7163.MCT-12-0232-T

Published: 09 October 2012

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NARROW

Development of Gene Expression–Based Score to Predict Sensitivity of Multiple Myeloma Cells to DNA Methylation Inhibitors

Targeting the Inhibitor of Apoptosis Proteins as a Novel Therapeutic Strategy in Medulloblastoma

Inhibiting Aurora Kinases Reduces Tumor Growth and Suppresses Tumor Recurrence after Chemotherapy in Patient-Derived Triple-Negative Breast Cancer Xenografts

Targeting KRAS-Mutant Non–Small Cell Lung Cancer with the Hsp90 Inhibitor Ganetespib

Bispecific and Trispecific Killer Cell Engagers Directly Activate Human NK Cells through CD16 Signaling and Induce Cytotoxicity and Cytokine Production

Regression of Human Prostate Cancer Xenografts in Mice by AMG 212/BAY2010112, a Novel PSMA/CD3-Bispecific BiTE Antibody Cross-Reactive with Non-Human Primate Antigens

BMS-754807, a Small-Molecule Inhibitor of Insulin-like Growth Factor-1 Receptor/Insulin Receptor, Enhances Gemcitabine Response in Pancreatic Cancer

Selective Targeting of Interferon γ to Stromal Fibroblasts and Pericytes as a Novel Therapeutic Approach to Inhibit Angiogenesis and Tumor Growth

O(6)-Methylguanine-DNA Methyltransferase Is a Novel Negative Effector of Invasion in Glioblastoma Multiforme

Perillyl Alcohol for the Treatment of Temozolomide-Resistant Gliomas

Inhibition of TGF-β Enhances the In Vivo Antitumor Efficacy of EGF Receptor–Targeted Therapy

Synthetic Lethal Screening with Small-Molecule Inhibitors Provides a Pathway to Rational Combination Therapies for Melanoma

Humanization of an Anti-CCR4 Antibody That Kills Cutaneous T-Cell Lymphoma Cells and Abrogates Suppression by T-Regulatory Cells

A Locked, Dimeric CXCL12 Variant Effectively Inhibits Pulmonary Metastasis of CXCR4-Expressing Melanoma Cells Due to Enhanced Serum Stability

Mechanistic Basis for Overcoming Platinum Resistance Using Copper Chelating Agents

Stromal Platelet-Derived Growth Factor Receptor α (PDGFRα) Provides a Therapeutic Target Independent of Tumor Cell PDGFRα Expression in Lung Cancer Xenografts

8-Amino-Adenosine Activates p53-Independent Cell Death of Metastatic Breast Cancers

Antitumor Activity of Triolimus: A Novel Multidrug-Loaded Micelle Containing Paclitaxel, Rapamycin, and 17-AAG

Active Efflux of Dasatinib from the Brain Limits Efficacy against Murine Glioblastoma: Broad Implications for the Clinical Use of Molecularly Targeted Agents

Garcinol Regulates EMT and Wnt Signaling Pathways In Vitro and In Vivo, Leading to Anticancer Activity against Breast Cancer Cells

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