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Journal Articles

Abstract P257: Preclinical data identifies bezuclastinib as a differentiated KIT inhibitor with unique selectivity to KIT D816V and minimal evidence of brain penetration

Anna Guarnieri, Mark Chicarelli, LouAnn Cable, Francis Sullivan, Howard Ball, Shannon Winski, John Robinson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P257.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P257
Published: 01 December 2021
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Journal Articles

Abstract P256: Pan-ErbB inhibition enhances activity of KRASG12C inhibitors in preclinical models of KRASG12C mutant cancers

Jacqulyne P. Robichaux, Ana Galan-Cobo, Ried T. Powell, Kelly A. Gale, Jun He, Fahao Zhang, Monique B. Nilsson, Xiang Zhang, Mary M. Sobieski, Nghi Nguyen, Stephan C. Clifford, John V. Heymach
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P256.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P256
Published: 01 December 2021
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Journal Articles

Abstract P158: Phenotypic analysis of myeloid cells in a 3D image-based repolarization assay with tumor spheroids

Gera Goverse, Nataliia Beztsinna, Benjamin Visser, Tomas Veenendaal, Marjan van de Merbel, Emma Spanjaard, Ashgard Weterings, Kuan Yan, Leo Price, Lidia Daszkiewicz
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P158.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P158
Published: 01 December 2021
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Journal Articles

Abstract P157: Targeting Trop2 for treatment of prostate and breast cancer

Tanya Stoyanova
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P157.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P157
Published: 01 December 2021
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Journal Articles

Abstract P156: Identification of previously unknown targets for approved small-molecule drugs using chemoproteomic platform IMTACTM

Vivian Zhang, Cindy Huang, Chao Zhang, Ping Cao
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P156.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P156
Published: 01 December 2021
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Journal Articles

Abstract P155: Heterogeneity of circulating tumor cell neoplastic subpopulations interrogated by single-cell transcriptomics

Dario Marchetti
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P155.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P155
Published: 01 December 2021
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Journal Articles

Abstract P154: Genomic profiling and matched therapy for recurrent or metastatic salivary gland neoplasms. Results from the matched cohort of the GEMS-001 clinical trial

Alberto Hernando-Calvo, Eoghan Malone, Daphne Dai, Amy Prawira, Ilan Weinreb, Anneli Eliason, Angela Rodriguez, Katherine Lajkosz, Sarah Jennings, Anna Spreafico, Lillian L. Siu, Aaron Hansen
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P154.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P154
Published: 01 December 2021
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Journal Articles

Abstract P153: Claudin-1 is a therapeutic target for hepatocellular carcinoma

Natascha Roehlen, Marion Muller, Sara Cherradi, Frank Juehling, Francois H.T. Duong, Nuno Almeida, Fabio Del Zompo, Mirian Fernandez, Tobias Riedl, Hussein El Saghire, Antonio Saviano, Sarah Durand, Clara Ponsolles, Marine Oudot, Emanuele Felli, Patrick Pessaux, Irwin Davidson, Emilie Crouchet, Patrick Laquerriere, Mathias Heikenwälder, Roberto Iacone, Markus Meyer, Greg Elson, Tamas Schweighoffer, Catherine Schuster, Laurent Mailly, Joachim Lupberger, Thomas F Baumert
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P153.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P153
Published: 01 December 2021
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Journal Articles

Abstract P150: PSMD1 and PSMD3 as putative targets for cancer therapy

Andres J. Rubio, Alfonso E. Bencomo-Alvarez, James E. Young, Vanessa V. Velazquez, Anna M. Eiring
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P150.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P150
Published: 01 December 2021
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Journal Articles

Abstract P149: Novel compounds to probe Hippo kinase STK3 noncanonical function in prostate cancer

Amelia U. Schirmer, Lucy M. Driver, Megan T. Zhao, Carrow I. Wells, Xuan Yang, David H. Drewry, Ivan Spasojevic, Everardo Macias
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P149.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P149
Published: 01 December 2021
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Journal Articles

Abstract P110: Neandertal introgressions contribute to upper aero-digestive tract tumor patient survival and identify patients who may benefit from STING agonist treatment

Antonio Gualberto, Tenghui Chen, Catherine Scholz, Jason Luke
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P110.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P110
Published: 01 December 2021
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Journal Articles

Abstract P109: Targeting BRD4 in T cells with self-delivering RNAi PH-894 for immunotherapy

Melissa Maxwell, Daisuke Ujiie, Benjamin Cuiffo, Brianna Rivest, Dingxue Yan, James Cardia, Jeroen Melief, Rolf Kiessling, Simon P. Fricker
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P109.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P109
Published: 01 December 2021
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Journal Articles

Abstract P108: In vivo CRISPR screens identify E3 ligase COP1 as a modulator of macrophage infiltration and cancer immunotherapy target

Xiaoqing Wang, Collin Tokheim, Shengqing S. Gu, Binbin Wang, Qin Tang, Yihao Li, Nicole Traugh, Zexian Zeng, Yi Zhang, Boning Zhang, Jingxin Fu, Tengfei Xiao, Wei Li, Clifford Meyer, Peng Jiang, Paloma Cejas, Klothilda Lim, Henry Long, Myles Brown, X. Shirley Liu
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P108.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P108
Published: 01 December 2021
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Journal Articles

Abstract P107: PSGL-1 blocking antibodies repolarize tumor associated macrophages, reduce suppressive myeloid populations and induce inflammation in the tumor microenvironment, leading to suppression of tumor growth

Ani Nguyen, Jessica Ritter, Mohammad Zafari, Denise Manfra, Veronica Komoroski, Brian O'Nuallain, Ryan Phennicie, Kevin Kauffman, Dominika Nowakowska, Joe Wahle, Steve Sazinsky, Michael Brehm, Igor Feldman, Tatiana Novobrantseva
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P107.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P107
Published: 01 December 2021
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Journal Articles

Abstract P094: Targeted sequencing revealed clonal genetic changes in spatially different foci in urothelial carcinoma of bladder

M. Talha Ugurlu, Rachel Goldberg, Pritam Sadhukhan, Mohammad O. Hoque
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P094.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P094
Published: 01 December 2021
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Journal Articles

Abstract P093: Proteomic analysis reveals a mechanism of resistance to radiation mediated by microvesicles in glioma

Elena Panizza, Brandon D. Regalado, Fangyu Wang, Robert J. Munroe, Nathaniel M. Vacanti, Marc A. Antonyak, Richard A. Cerione
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P093.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P093
Published: 01 December 2021
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Journal Articles

Abstract P092: A novel approach to target drug-resistance in thyroid cancer by regulating Annexin 7 (ANXA7)/p21 axis

Surya Radhakrishnan, Alakesh Bera, Narayanan Puthillathu, Nahbuma Gana, Madhan Subramanian, Eric Russ, Anubhuti Paria, Swarnarup Paria, Stephen Rothwell, Harvey B. Pollard, Meera Srivastava
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P092.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P092
Published: 01 December 2021
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Journal Articles

Abstract P089: Discovery of novel small-molecule inhibitors for an epigenetic modulator WDR5

Cindy Huang, Shirley Guo, Ping Cao
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P089.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P089
Published: 01 December 2021
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Journal Articles

Abstract P041: Initial results from a phase 1b study of ORIC-101, a glucocorticoid receptor antagonist, in combination with enzalutamide in patients with metastatic prostate cancer

Wassim Abida, Neeraj Agarwal, Andrew W. Hahn, Neal Shore, Paul Sieber, Tanya Dorff, Mathew Rettig, Mathew Smith, Paul Monk, Rongda Xu, Ann Johnson, Anneleen Daemen, Edna Chow Maneval, Pratik S. Multani, Rupal Patel, Michael J. Morris
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P041.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P041
Published: 01 December 2021
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Abstract P039: A phase 1 dose escalation study of protein arginine methyltransferase 5 (PRMT5) inhibitor PRT543 in patients with advanced solid tumors and lymphoma

Meredith McKean, Manish R. Patel, Robert Wesolowski, Renata Ferrarotto, Eytan M. Stein, Alexander N. Shoushtari, David Mauro, John Viscusi, Peggy Scherle, Neha Bhagwat, William Sun, Rachel Chiaverelli, Eric Mintah, Shekeab Jauhari, Laura Finn, Neil D. Palmisiano, Robert A. Baiocchi
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P039.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P039
Published: 01 December 2021
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