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Poster Presentations - Proffered Abstracts
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Journal Articles

Abstract P171: Ligand-displaying-exosomes using RNA nanotechnology for targeted delivery of multispecific drugs for liver cancer regression

Xin Li, Satheesh Ellipilli, Hongzhi Wang, Wen-Jui Lee, Yuan Soon Ho, Peixuan Guo
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P171.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P171
Published: 01 December 2021
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Journal Articles

Abstract P170: SpliceCore® a platform for identifying aberrant alternative splicing in triple negative breast cancer for novel therapeutic development

Miguel A. Manzanares, Dhingra Priyanka, Kendall Anderson, Vanessa Frederick, Adam Geier, Alyssa Casill, Martin Akerman, Gayatri Arun
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P170.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P170
Published: 01 December 2021
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Abstract P169: Dynamic cell-level modeling of antibody binding and internalization for radiosensitivity assessements in alpha-emitter radiopharmaceutical therapy

Remco Bastiaannet, Ioanna Liatsou, Robert Hobbs, George Sgouros
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P169.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P169
Published: 01 December 2021
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Journal Articles

Abstract P168: Pretargeted radioimmunotherapy using 225Ac for intraperitoneal Her2-expressing epithelial ovarian carcinoma xenografts

Sebastian K. Chung, Christopher S. Chandler, Daniela Burnes Vargas, Shin H. Seo, Michael R. McDevitt, Darren Veach, Blesida Punzalan, Xu Hong, Hong-fen Guo, Garrett M. Nash, Andrea Cercek, Nai-Kong V. Cheung, Steven M. Larson, Sarah M. Cheal
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P168.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P168
Published: 01 December 2021
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Journal Articles

Abstract P106: Reprogramming regulatory T cells (Treg) using a MALT1 inhibitor for cancer therapy

Peter Keller, Irina Mazo, Yun Gao, Vijayapal Reddy, Francisco Caballero, Sam Kazer, Dannah Miller, Roberto Gianani, James E. Marvin, Bret Stephens, Gregory L. Beatty, Ulrich H. von Andrian, Thorsten R. Mempel
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P106.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P106
Published: 01 December 2021
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Journal Articles

Abstract P105: Targeting VSIG4, a novel macrophage checkpoint, repolarizes suppressive macrophages which induces an inflammatory response in primary cell in vitro assays and fresh human tumor cultures

Steve Sazinsky, Ani Nguyen, Mohammad Zafari, Ryan Phennicie, Joe Wahle, Veronica Komoroski, Kathryn Rooney, Craig Mizzoni, Boris Klebanov, Jessica Ritter, Denise Manfra, Igor Feldman, Tatiana Novobrantseva
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P105.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P105
Published: 01 December 2021
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Journal Articles

Abstract P257: Preclinical data identifies bezuclastinib as a differentiated KIT inhibitor with unique selectivity to KIT D816V and minimal evidence of brain penetration

Anna Guarnieri, Mark Chicarelli, LouAnn Cable, Francis Sullivan, Howard Ball, Shannon Winski, John Robinson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P257.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P257
Published: 01 December 2021
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Journal Articles

Abstract P256: Pan-ErbB inhibition enhances activity of KRASG12C inhibitors in preclinical models of KRASG12C mutant cancers

Jacqulyne P. Robichaux, Ana Galan-Cobo, Ried T. Powell, Kelly A. Gale, Jun He, Fahao Zhang, Monique B. Nilsson, Xiang Zhang, Mary M. Sobieski, Nghi Nguyen, Stephan C. Clifford, John V. Heymach
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P256.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P256
Published: 01 December 2021
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Journal Articles

Abstract P158: Phenotypic analysis of myeloid cells in a 3D image-based repolarization assay with tumor spheroids

Gera Goverse, Nataliia Beztsinna, Benjamin Visser, Tomas Veenendaal, Marjan van de Merbel, Emma Spanjaard, Ashgard Weterings, Kuan Yan, Leo Price, Lidia Daszkiewicz
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P158.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P158
Published: 01 December 2021
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Journal Articles

Abstract P157: Targeting Trop2 for treatment of prostate and breast cancer

Tanya Stoyanova
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P157.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P157
Published: 01 December 2021
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Journal Articles

Abstract P156: Identification of previously unknown targets for approved small-molecule drugs using chemoproteomic platform IMTACTM

Vivian Zhang, Cindy Huang, Chao Zhang, Ping Cao
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P156.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P156
Published: 01 December 2021
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Journal Articles

Abstract P155: Heterogeneity of circulating tumor cell neoplastic subpopulations interrogated by single-cell transcriptomics

Dario Marchetti
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P155.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P155
Published: 01 December 2021
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Journal Articles

Abstract P154: Genomic profiling and matched therapy for recurrent or metastatic salivary gland neoplasms. Results from the matched cohort of the GEMS-001 clinical trial

Alberto Hernando-Calvo, Eoghan Malone, Daphne Dai, Amy Prawira, Ilan Weinreb, Anneli Eliason, Angela Rodriguez, Katherine Lajkosz, Sarah Jennings, Anna Spreafico, Lillian L. Siu, Aaron Hansen
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P154.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P154
Published: 01 December 2021
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Journal Articles

Abstract P153: Claudin-1 is a therapeutic target for hepatocellular carcinoma

Natascha Roehlen, Marion Muller, Sara Cherradi, Frank Juehling, Francois H.T. Duong, Nuno Almeida, Fabio Del Zompo, Mirian Fernandez, Tobias Riedl, Hussein El Saghire, Antonio Saviano, Sarah Durand, Clara Ponsolles, Marine Oudot, Emanuele Felli, Patrick Pessaux, Irwin Davidson, Emilie Crouchet, Patrick Laquerriere, Mathias Heikenwälder, Roberto Iacone, Markus Meyer, Greg Elson, Tamas Schweighoffer, Catherine Schuster, Laurent Mailly, Joachim Lupberger, Thomas F Baumert
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P153.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P153
Published: 01 December 2021
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Abstract P150: PSMD1 and PSMD3 as putative targets for cancer therapy

Andres J. Rubio, Alfonso E. Bencomo-Alvarez, James E. Young, Vanessa V. Velazquez, Anna M. Eiring
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P150.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P150
Published: 01 December 2021
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Journal Articles

Abstract P149: Novel compounds to probe Hippo kinase STK3 noncanonical function in prostate cancer

Amelia U. Schirmer, Lucy M. Driver, Megan T. Zhao, Carrow I. Wells, Xuan Yang, David H. Drewry, Ivan Spasojevic, Everardo Macias
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P149.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P149
Published: 01 December 2021
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Journal Articles

Abstract P110: Neandertal introgressions contribute to upper aero-digestive tract tumor patient survival and identify patients who may benefit from STING agonist treatment

Antonio Gualberto, Tenghui Chen, Catherine Scholz, Jason Luke
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P110.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P110
Published: 01 December 2021
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Abstract P109: Targeting BRD4 in T cells with self-delivering RNAi PH-894 for immunotherapy

Melissa Maxwell, Daisuke Ujiie, Benjamin Cuiffo, Brianna Rivest, Dingxue Yan, James Cardia, Jeroen Melief, Rolf Kiessling, Simon P. Fricker
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P109.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P109
Published: 01 December 2021
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Abstract P108: In vivo CRISPR screens identify E3 ligase COP1 as a modulator of macrophage infiltration and cancer immunotherapy target

Xiaoqing Wang, Collin Tokheim, Shengqing S. Gu, Binbin Wang, Qin Tang, Yihao Li, Nicole Traugh, Zexian Zeng, Yi Zhang, Boning Zhang, Jingxin Fu, Tengfei Xiao, Wei Li, Clifford Meyer, Peng Jiang, Paloma Cejas, Klothilda Lim, Henry Long, Myles Brown, X. Shirley Liu
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P108.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P108
Published: 01 December 2021
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Abstract P107: PSGL-1 blocking antibodies repolarize tumor associated macrophages, reduce suppressive myeloid populations and induce inflammation in the tumor microenvironment, leading to suppression of tumor growth

Ani Nguyen, Jessica Ritter, Mohammad Zafari, Denise Manfra, Veronica Komoroski, Brian O'Nuallain, Ryan Phennicie, Kevin Kauffman, Dominika Nowakowska, Joe Wahle, Steve Sazinsky, Michael Brehm, Igor Feldman, Tatiana Novobrantseva
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P107.
DOI: https://doi.org/10.1158/1535-7163.TARG-21-P107
Published: 01 December 2021
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