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Abstract 1225: LNS8801: A novel, enantiomerically pure, small molecule agonist of the G protein-coupled estrogen receptor (GPER) for the treatment of cancer

Chris Natale, Tina Garyantes, Todd Ridky

Cancer Res (2021) 81 (13_Supplement): 1225.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1225

Published: 01 July 2021

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Journal Articles

Abstract 1224: Discovery of novel BAF inhibitors for the treatment of transcription factor-driven cancers

Cancer Res (2021) 81 (13_Supplement): 1224.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1224

Published: 01 July 2021

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Abstract 1213: PDE10A as a novel target to suppress Wnt/β-catenin signaling and other oncogenic pathways in ovarian cancer

Rebecca M. Barber, Elaine Gavin, Alla Musiyenko, Wito Richter, Kevin J. Lee, Annelise Wilhite, Joel F. Andrews, Steve McClellan, Ileana Aragon, Antonio Ward, Xi Chen, Adam Keeton, Kristy Berry, Gary A. Piazza, Jennifer M. Scalici, Luciana Madeira da Silva

Cancer Res (2021) 81 (13_Supplement): 1213.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1213

Published: 01 July 2021

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Abstract 1205: Clinical and genomic features of advanced urothelial carcinoma with 9p21 deletion

Andre L. De Souza, Praveen Srinivasan, Luke B. Soliman, Dragan J. Golijanin, Ali Amin, Howard Safran, Anthony E. Mega, Wafik S. El-Deiry, Benedito A. Carneiro

Cancer Res (2021) 81 (13_Supplement): 1205.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1205

Published: 01 July 2021

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Abstract 1204: SO-N102, a novel CLDN18.2-targeting antibody-drug conjugate with strong anti-tumor effect in various solid tumors expressing low target levels

Lenka Kyrych Sadilkova, Iva Valentova, Simona Hoskova, Pavel Vopalensky, Lukas Bammert, Roger Beerli, Ulrich Moebius, Radek Spisek

Cancer Res (2021) 81 (13_Supplement): 1204.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1204

Published: 01 July 2021

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Abstract 1222: Validating the WD repeat protein CDC40 as a potential therapeutic target for lung cancer

Die Hu, Brigitte L. Thériault, Vida Talebian, Julie Owen, Richard Marcellus, Rima Al-awar

Cancer Res (2021) 81 (13_Supplement): 1222.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1222

Published: 01 July 2021

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Abstract 1206: Discovery and characterization of AB521, a novel, potent, and selective hypoxia-inducible factor (HIF)-2α inhibitor

Cancer Res (2021) 81 (13_Supplement): 1206.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1206

Published: 01 July 2021

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Abstract 1203: ZL-1211 exhibits broad anti-tumor activity in CLDN18.2 high- and low-expressing models

Cancer Res (2021) 81 (13_Supplement): 1203.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1203

Published: 01 July 2021

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Abstract 1228: Novel small molecule inhibitors that target the exportin binding pocket of TOP2A for the treatment of multiple myeloma

Joel G. Turner, David Ostrov, Nicholas Lawrence, Jana Dawson, Juan Gomez, Alexis Bauer, Mark Meads, Alex Achille, Kenneth Shain

Cancer Res (2021) 81 (13_Supplement): 1228.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1228

Published: 01 July 2021

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Abstract 1215: Targeting TIP1 with a novel radiosensitizing antibody-drug conjugate (ADC) enhances the therapeutic efficacy of radiation for non-small cell lung carcinoma treatment

Calvin Lewis, Abhay K. Singh, Dinesh Thotala, Dennis E. Hallahan, Vaishali Kapoor

Cancer Res (2021) 81 (13_Supplement): 1215.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1215

Published: 01 July 2021

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Abstract 1207: Thymoquinone-based drug development targeting SUCLA2 loss in advanced prostate cancer

Chiaki Takahashi

Cancer Res (2021) 81 (13_Supplement): 1207.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1207

Published: 01 July 2021

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Abstract 1216: New therapeutic antibody ("WM-A1") for treatment of low or no PD-L1 NSCLC patients

Hye jin Son, Minki Lee, Seongrak Kim, Jai-Hee Moon, Hana Kim, Wonhwa Shin, Joseph Kim, Mi So Lee, Daeun Kim, Seunggeon Bae, Joonyee Jeong, Seung-Woo Hong, Chun-Ho Park, Hyun Ho Lee, Dong-Hoon Jin

Cancer Res (2021) 81 (13_Supplement): 1216.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1216

Published: 01 July 2021

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Abstract 1208: Identifying a novel glycolytic inhibitor for treatment of aggressive prostate cancer

Tanya Ivanova Stoyanova

Cancer Res (2021) 81 (13_Supplement): 1208.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1208

Published: 01 July 2021

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Abstract 1201: Amentoflavone inhibits cell growth and metastasis in colorectal cancer was associated with the suppression of KIAA1199

Hsiang-Ju Ku, Zhao-Lin Tan, I-Tsang Chiang, Yuan Chang, Fei-Ting Hsu

Cancer Res (2021) 81 (13_Supplement): 1201.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1201

Published: 01 July 2021

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Abstract 1202: ERG344: A novel IRG1 inhibitor for the treatment of colon cancer

Adonia E. Papathanassiu, Francesca Lodi, Hong A. Vu, Diether Lambrechts

Cancer Res (2021) 81 (13_Supplement): 1202.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1202

Published: 01 July 2021

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Abstract 1227: Oncofusion driven de novo enhancer assembly promotes malignancy in Ewing sarcomavia aberrant expression of the stereociliary protein LOXHD1

Qu Deng, Ramakrishnan Natesan, Florencia Cidre-Aranz, Shehbeel Arif, Ying Liu, Reyaz Rasool, Pei Wang, Zvi Crammer, Margaret Chou, Chandan Kumar, Kristy Weber, Karin Eisinger, Nicolas Grillet, Thomas Grünewald, Irfan Asangani

Cancer Res (2021) 81 (13_Supplement): 1227.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1227

Published: 01 July 2021

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Abstract 1226: Targeting OSCC fitness genes YAP1 and WWTR1 via synergistic killing of CA3 in combination with cisplatin

Annie Wai Yeeng Chai, Pei San Yee, Shi Mun Yee, Sok Ching Cheong

Cancer Res (2021) 81 (13_Supplement): 1226.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1226

Published: 01 July 2021

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Abstract 1218: Targeting B-RAF and checkpoint inhibitor resistant melanoma with RSK inhibitor PMD-026 in pre-clinical models

Joe William Ramos, Stephanie Si, Takeo Fujii, Brien Haun, Won Seok Yang, Aarthi Jayanthan, Sandra E. Dunn

Cancer Res (2021) 81 (13_Supplement): 1218.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1218

Published: 01 July 2021

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Abstract 1200: Long-duration term TTFields treatment of glioblastoma cells induces cell death

Stefania Castiglione, Matteo Ranucci, Gaetano Cannavale, Francesca Cianci, Ivan Verduci, Michele Mazzanti

Cancer Res (2021) 81 (13_Supplement): 1200.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1200

Published: 01 July 2021

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Journal Articles

Abstract 1210: NFX1-123: A potential therapeutic target in cancer

Sreenivasulu Chintala, Anand Anbarasu, Rachel A. Katzenellenbogen

Cancer Res (2021) 81 (13_Supplement): 1210.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1210

Published: 01 July 2021

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2 3 4 5

NARROW

Abstract 1225: LNS8801: A novel, enantiomerically pure, small molecule agonist of the G protein-coupled estrogen receptor (GPER) for the treatment of cancer

Abstract 1224: Discovery of novel BAF inhibitors for the treatment of transcription factor-driven cancers

Abstract 1213: PDE10A as a novel target to suppress Wnt/β-catenin signaling and other oncogenic pathways in ovarian cancer

Abstract 1205: Clinical and genomic features of advanced urothelial carcinoma with 9p21 deletion

Abstract 1204: SO-N102, a novel CLDN18.2-targeting antibody-drug conjugate with strong anti-tumor effect in various solid tumors expressing low target levels

Abstract 1222: Validating the WD repeat protein CDC40 as a potential therapeutic target for lung cancer

Abstract 1206: Discovery and characterization of AB521, a novel, potent, and selective hypoxia-inducible factor (HIF)-2α inhibitor

Abstract 1203: ZL-1211 exhibits broad anti-tumor activity in CLDN18.2 high- and low-expressing models

Abstract 1228: Novel small molecule inhibitors that target the exportin binding pocket of TOP2A for the treatment of multiple myeloma

Abstract 1215: Targeting TIP1 with a novel radiosensitizing antibody-drug conjugate (ADC) enhances the therapeutic efficacy of radiation for non-small cell lung carcinoma treatment

Abstract 1207: Thymoquinone-based drug development targeting SUCLA2 loss in advanced prostate cancer

Abstract 1216: New therapeutic antibody ("WM-A1") for treatment of low or no PD-L1 NSCLC patients

Abstract 1208: Identifying a novel glycolytic inhibitor for treatment of aggressive prostate cancer

Abstract 1201: Amentoflavone inhibits cell growth and metastasis in colorectal cancer was associated with the suppression of KIAA1199

Abstract 1202: ERG344: A novel IRG1 inhibitor for the treatment of colon cancer

Abstract 1227: Oncofusion driven de novo enhancer assembly promotes malignancy in Ewing sarcomavia aberrant expression of the stereociliary protein LOXHD1

Abstract 1226: Targeting OSCC fitness genes YAP1 and WWTR1 via synergistic killing of CA3 in combination with cisplatin

Abstract 1218: Targeting B-RAF and checkpoint inhibitor resistant melanoma with RSK inhibitor PMD-026 in pre-clinical models

Abstract 1200: Long-duration term TTFields treatment of glioblastoma cells induces cell death

Abstract 1210: NFX1-123: A potential therapeutic target in cancer

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