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Journal Articles

Redefining CD56 as a Biomarker and Therapeutic Target in Multiple Myeloma

Francesca Cottini, Jose Rodriguez, Tiffany Hughes, Nidhi Sharma, Ling Guo, Gerard Lozanski, Bei Liu, Emanuele Cocucci, Yiping Yang, Don Benson

Mol Cancer Res OF1–OF13.

DOI: https://doi.org/10.1158/1541-7786.MCR-21-0828

Published: 04 May 2022

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Includes: Supplementary data

Journal Articles

Hypoxia Drives Centrosome Amplification in Cancer Cells via HIF1α-dependent Induction of Polo-Like Kinase 4

Karuna Mittal, Jaspreet Kaur, Shaligram Sharma, Nivya Sharma, Guanhao Wei, Ishita Choudhary, Precious Imhansi-Jacob, Nagini Maganti, Shrikant Pawar, Padmashree Rida, Michael S. Toss, Mohammed Aleskandarany, Emiel A. Janssen, Håvard Søiland, Meenakshi. V. Gupta, Michelle D. Reid, Emad A. Rakha, Ritu Aneja

Mol Cancer Res (2022) 20 (4): 596–606.

DOI: https://doi.org/10.1158/1541-7786.MCR-20-0798

Published: 01 April 2022

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Includes: Supplementary data

Journal Articles

Selective Vulnerability of Senescent Glioblastoma Cells to BCL-XL Inhibition

Mol Cancer Res OF1–OF11.

DOI: https://doi.org/10.1158/1541-7786.MCR-21-0029

Published: 16 March 2022

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Includes: Supplementary data

Journal Articles

Syntaxin4-Munc18c Interaction Promotes Breast Tumor Invasion and Metastasis by Regulating MT1-MMP Trafficking

Megan I. Brasher, Shawn C. Chafe, Paul C. McDonald, Oksana Nemirovsky, Genya Gorshtein, Zachary J. Gerbec, Wells S. Brown, Olivia R. Grafinger, Matthew Marchment, Esther Matus, Shoukat Dedhar, Marc G. Coppolino

Mol Cancer Res (2022) 20 (3): 434–445.

DOI: https://doi.org/10.1158/1541-7786.MCR-20-0527

Published: 03 March 2022

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Journal Articles

Deregulation of AKT–mTOR Signaling Contributes to Chemoradiation Resistance in Lung Squamous Cell Carcinoma

Changxian Shen, Duan-Liang Shyu, Min Xu, Linlin Yang, Amy Webb, Wenrui Duan, Terence M. Williams

Mol Cancer Res (2022) 20 (3): 425–433.

DOI: https://doi.org/10.1158/1541-7786.MCR-21-0272

Published: 03 March 2022

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Includes: Supplementary data

Journal Articles

A Novel Therapeutic Strategy Targeting the Mesenchymal Phenotype of Malignant Pleural Mesothelioma by Suppressing LSD1

Aditya Wirawan, Ken Tajima, Fumiyuki Takahashi, Yoichiro Mitsuishi, Wira Winardi, Moulid Hidayat, Daisuke Hayakawa, Naohisa Matsumoto, Kenta Izumi, Tetsuhiko Asao, Ryo Ko, Naoko Shimada, Kazuya Takamochi, Kenji Suzuki, Masaaki Abe, Okio Hino, Yoshitaka Sekido, Kazuhisa Takahashi

Mol Cancer Res (2022) 20 (1): 127–138.

DOI: https://doi.org/10.1158/1541-7786.MCR-21-0230

Published: 05 January 2022

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Includes: Supplementary data

Journal Articles

Heme Sequestration Effectively Suppresses the Development and Progression of Both Lung Adenocarcinoma and Squamous Cell Carcinoma

Sanchareeka Dey, Adnin Ashrafi, Chantal Vidal, Nivesh Jain, Sarada Preeta Kalainayakan, Poorva Ghosh, Parinaz Sadat Alemi, Narges Salamat, Purna Chaitanya Konduri, Jung-whan Kim, Li Zhang

Mol Cancer Res (2022) 20 (1): 139–149.

DOI: https://doi.org/10.1158/1541-7786.MCR-21-0385

Published: 05 January 2022

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Includes: Supplementary data

Journal Articles

Gene Body Methylation of the Lymphocyte-Specific Gene CARD11 Results in Its Overexpression and Regulates Cancer mTOR Signaling

Michael H. McGuire, Santosh K. Dasari, Hui Yao, Yunfei Wen, Lingegowda S. Mangala, Emine Bayraktar, Wencai Ma, Cristina Ivan, Einav Shoshan, Sherry Y. Wu, Eric Jonasch, Menashe Bar-Eli, Jing Wang, Keith A. Baggerly, Anil K. Sood

Mol Cancer Res (2021) 19 (11): 1917–1928.

DOI: https://doi.org/10.1158/1541-7786.MCR-20-0753

Published: 01 November 2021

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Includes: Supplementary data

Journal Articles

NP-ALT, a Liposomal:Peptide Drug, Blocks p27Kip1 Phosphorylation to Induce Oxidative Stress, Necroptosis, and Regression in Therapy-Resistant Breast Cancer Cells

Irina Jilishitz, Jason Luis Quiñones, Priyank Patel, Grace Chen, Jared Pasetsky, Allison VanInwegen, Scott Schoninger, Manasi P. Jogalekar, Vladislav Tsiperson, Lingyue Yan, Yun Wu, Susan R.S. Gottesman, Jonathan Somma, Stacy W. Blain

Mol Cancer Res (2021) 19 (11): 1929–1945.

DOI: https://doi.org/10.1158/1541-7786.MCR-21-0081

Published: 01 November 2021

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Includes: Supplementary data

Journal Articles

Radium-223–Induced Bystander Effects Cause DNA Damage and Apoptosis in Disseminated Tumor Cells in Bone Marrow

Brian S. Canter, Calvin N. Leung, J. Christopher Fritton, Tom Bäck, Didier Rajon, Edouard I. Azzam, Roger W. Howell

Mol Cancer Res (2021) 19 (10): 1739–1750.

DOI: https://doi.org/10.1158/1541-7786.MCR-21-0005

Published: 01 October 2021

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Includes: Supplementary data

Journal Articles

TSC2 Interacts with HDLBP/Vigilin and Regulates Stress Granule Formation

Kosmas Kosmas, Harilaos Filippakis, Damir Khabibullin, Michal Turkiewicz, Hilaire C. Lam, Jane Yu, Nancy L. Kedersha, Paul J. Anderson, Elizabeth P. Henske

Mol Cancer Res (2021) 19 (8): 1389–1397.

DOI: https://doi.org/10.1158/1541-7786.MCR-20-1046

Published: 01 August 2021

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Includes: Supplementary data

Journal Articles

Defects in Emerin–Nucleoskeleton Binding Disrupt Nuclear Structure and Promote Breast Cancer Cell Motility and Metastasis

Alexandra G. Liddane, Chelsea A. McNamara, Mallory C. Campbell, Isabelle Mercier, James M. Holaska

Mol Cancer Res (2021) 19 (7): 1196–1207.

DOI: https://doi.org/10.1158/1541-7786.MCR-20-0413

Published: 01 July 2021

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Includes: Supplementary data

Journal Articles

Circulating Tumor Cell Genomic Evolution and Hormone Therapy Outcomes in Men with Metastatic Castration-Resistant Prostate Cancer

Santosh Gupta, Susan Halabi, Gabor Kemeny, Monika Anand, Paraskevi Giannakakou, David M. Nanus, Daniel J. George, Simon G. Gregory, Andrew J. Armstrong

Mol Cancer Res (2021) 19 (6): 1040–1050.

DOI: https://doi.org/10.1158/1541-7786.MCR-20-0975

Published: 01 June 2021

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Includes: Supplementary data

Journal Articles

Development and Characterization of Novel Endoxifen-Resistant Breast Cancer Cell Lines Highlight Numerous Differences from Tamoxifen-Resistant Models

Calley J. Jones, Malayannan Subramaniam, Michael J. Emch, Elizabeth S. Bruinsma, James N. Ingle, Matthew P. Goetz, John R. Hawse

Mol Cancer Res (2021) 19 (6): 1026–1039.

DOI: https://doi.org/10.1158/1541-7786.MCR-20-0872

Published: 01 June 2021

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Includes: Supplementary data

Journal Articles

Inhibition of O-GlcNAc Transferase Renders Prostate Cancer Cells Dependent on CDK9

Harri M. Itkonen, Ninu Poulose, Rebecca E. Steele, Sara E.S. Martin, Zebulon G. Levine, Damien Y. Duveau, Ryan Carelli, Reema Singh, Alfonso Urbanucci, Massimo Loda, Craig J. Thomas, Ian G. Mills, Suzanne Walker

Mol Cancer Res (2020) 18 (10): 1512–1521.

DOI: https://doi.org/10.1158/1541-7786.MCR-20-0339

Published: 02 October 2020

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Includes: Supplementary data

Journal Articles

HCN Channel Activity Balances Quiescence and Proliferation in Neural Stem Cells and Is a Selective Target for Neuroprotection During Cancer Treatment

Helena Johard, Anna Omelyanenko, Gao Fei, Misha Zilberter, Zankruti Dave, Randa Abu-Youssef, Linnéa Schmidt, Aditya Harisankar, C. Theresa Vincent, Julian Walfridsson, Sven Nelander, Tibor Harkany, Klas Blomgren, Michael Andäng

Mol Cancer Res (2020) 18 (10): 1522–1533.

DOI: https://doi.org/10.1158/1541-7786.MCR-20-0292

Published: 02 October 2020

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Includes: Supplementary data

Journal Articles

Chromosome 6p Amplification in Aqueous Humor Cell-Free DNA Is a Prognostic Biomarker for Retinoblastoma Ocular Survival

Liya Xu, Ashley Polski, Rishvanth K. Prabakar, Mark W. Reid, Patricia Chevez-Barrios, Rima Jubran, Jonathan W. Kim, Peter Kuhn, David Cobrinik, James Hicks, Jesse L. Berry

Mol Cancer Res (2020) 18 (8): 1166–1175.

DOI: https://doi.org/10.1158/1541-7786.MCR-19-1262

Published: 04 August 2020

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Includes: Supplementary data

Journal Articles

Kinetics of Nuclear Uptake and Site-Specific DNA Cleavage during CRISPR-Directed Gene Editing in Solid Tumor Cells

Kelly Banas, Natalia Rivera-Torres, Pawel Bialk, Byung-Chun Yoo, Eric B. Kmiec

Mol Cancer Res (2020) 18 (6): 891–902.

DOI: https://doi.org/10.1158/1541-7786.MCR-19-1208

Published: 02 June 2020

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Includes: Supplementary data

Journal Articles

Endogenous PAD4 in Breast Cancer Cells Mediates Cancer Extracellular Chromatin Network Formation and Promotes Lung Metastasis

Lai Shi, Huanling Yao, Zheng Liu, Ming Xu, Allan Tsung, Yanming Wang

Mol Cancer Res (2020) 18 (5): 735–747.

DOI: https://doi.org/10.1158/1541-7786.MCR-19-0018

Published: 04 May 2020

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Journal Articles

A Novel Zebrafish Model of Metastasis Identifies the HSD11β1 Inhibitor Adrenosterone as a Suppressor of Epithelial–Mesenchymal Transition and Metastatic Dissemination

Joji Nakayama, Jeng-Wei Lu, Hideki Makinoshima, Zhiyuan Gong

Mol Cancer Res (2020) 18 (3): 477–487.

DOI: https://doi.org/10.1158/1541-7786.MCR-19-0759

Published: 02 March 2020

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Includes: Supplementary data

NARROW

Redefining CD56 as a Biomarker and Therapeutic Target in Multiple Myeloma

Hypoxia Drives Centrosome Amplification in Cancer Cells via HIF1α-dependent Induction of Polo-Like Kinase 4

Selective Vulnerability of Senescent Glioblastoma Cells to BCL-XL Inhibition

Syntaxin4-Munc18c Interaction Promotes Breast Tumor Invasion and Metastasis by Regulating MT1-MMP Trafficking

Deregulation of AKT–mTOR Signaling Contributes to Chemoradiation Resistance in Lung Squamous Cell Carcinoma

A Novel Therapeutic Strategy Targeting the Mesenchymal Phenotype of Malignant Pleural Mesothelioma by Suppressing LSD1

Heme Sequestration Effectively Suppresses the Development and Progression of Both Lung Adenocarcinoma and Squamous Cell Carcinoma

Gene Body Methylation of the Lymphocyte-Specific Gene CARD11 Results in Its Overexpression and Regulates Cancer mTOR Signaling

NP-ALT, a Liposomal:Peptide Drug, Blocks p27Kip1 Phosphorylation to Induce Oxidative Stress, Necroptosis, and Regression in Therapy-Resistant Breast Cancer Cells

Radium-223–Induced Bystander Effects Cause DNA Damage and Apoptosis in Disseminated Tumor Cells in Bone Marrow

TSC2 Interacts with HDLBP/Vigilin and Regulates Stress Granule Formation

Defects in Emerin–Nucleoskeleton Binding Disrupt Nuclear Structure and Promote Breast Cancer Cell Motility and Metastasis

Circulating Tumor Cell Genomic Evolution and Hormone Therapy Outcomes in Men with Metastatic Castration-Resistant Prostate Cancer

Development and Characterization of Novel Endoxifen-Resistant Breast Cancer Cell Lines Highlight Numerous Differences from Tamoxifen-Resistant Models

Inhibition of O-GlcNAc Transferase Renders Prostate Cancer Cells Dependent on CDK9

HCN Channel Activity Balances Quiescence and Proliferation in Neural Stem Cells and Is a Selective Target for Neuroprotection During Cancer Treatment

Chromosome 6p Amplification in Aqueous Humor Cell-Free DNA Is a Prognostic Biomarker for Retinoblastoma Ocular Survival

Kinetics of Nuclear Uptake and Site-Specific DNA Cleavage during CRISPR-Directed Gene Editing in Solid Tumor Cells

Endogenous PAD4 in Breast Cancer Cells Mediates Cancer Extracellular Chromatin Network Formation and Promotes Lung Metastasis

A Novel Zebrafish Model of Metastasis Identifies the HSD11β1 Inhibitor Adrenosterone as a Suppressor of Epithelial–Mesenchymal Transition and Metastatic Dissemination

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