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Journal Articles

Autocrine GMCSF Signaling Contributes to Growth of HER2⁺ Breast Leptomeningeal Carcinomatosis

Khairul I. Ansari, Arunoday Bhan, Mika Saotome, Antariksh Tyagi, Bony De Kumar, Clara Chen, Motoki Takaku, Rahul Jandial

Cancer Res (2021) 81 (18): 4723–4735.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-0259

Published: 16 September 2022

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Includes: Supplementary data

Journal Articles

Aberrant Nuclear Export of circNCOR1 Underlies SMAD7-Mediated Lymph Node Metastasis of Bladder Cancer

Mingjie An, Hanhao Zheng, Jian Huang, Yan Lin, Yuming Luo, Yao Kong, Mingrui Pang, Dingwen Zhang, Jiabin Yang, Jiancheng Chen, Yuanlong Li, Changhao Chen, Tianxin Lin

Cancer Res (2022) 82 (12): 2239–2253.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-4349

Published: 15 June 2022

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Includes: Supplementary data

Journal Articles

Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer

Xiuchao Wang, Yunzhan Li, Zekun Li, Shengchen Lin, Hongwei Wang, Jianwei Sun, Chungen Lan, Liangliang Wu, Dongxiao Sun, Chongbiao Huang, Pankaj K. Singh, Nadine Hempel, Mohamed Trebak, Gina M. DeNicola, Jihui Hao, Shengyu Yang

Cancer Res (2022) 82 (12): 2254–2268.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-3230

Published: 15 June 2022

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Includes: Multimedia, Supplementary data

Journal Articles

Rab13 Sustains Breast Cancer Stem Cells by Supporting Tumor–Stroma Cross-talk

Hui Wang, Haibo Xu, Wei Chen, Mei Cheng, Li Zou, Qin Yang, Chi Bun Chan, Hao Zhu, Ceshi Chen, Jianyun Nie, Baowei Jiao

Cancer Res (2022) 82 (11): 2124–2140.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-4097

Published: 06 June 2022

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Includes: Supplementary data

Journal Articles

A Genome-Wide CRISPR Activation Screen Identifies PRRX2 as a Regulator of Enzalutamide Resistance in Prostate Cancer

Yara Rodríguez, Kenji Unno, Mihai I. Truica, Zachary R. Chalmers, Young A. Yoo, Rajita Vatapalli, Vinay Sagar, Jindan Yu, Barbara Lysy, Maha Hussain, Huiying Han, Sarki A. Abdulkadir

Cancer Res (2022) 82 (11): 2110–2123.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-3565

Published: 06 June 2022

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Includes: Supplementary data

Journal Articles

Phosphorylation of SHP2 at Tyr62 Enables Acquired Resistance to SHP2 Allosteric Inhibitors in FLT3-ITD–Driven AML

Anamarija Pfeiffer, Giulia Franciosa, Marie Locard-Paulet, Ilaria Piga, Kristian Reckzeh, Vidyasiri Vemulapalli, Stephen C. Blacklow, Kim Theilgaard-Mönch, Lars J. Jensen, Jesper V. Olsen

Cancer Res (2022) 82 (11): 2141–2155.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-0548

Published: 06 June 2022

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Includes: Supplementary data

Journal Articles

TET2 Suppresses VHL Deficiency-Driven Clear Cell Renal Cell Carcinoma by Inhibiting HIF Signaling

Xinchao Zhang, Shuyan Li, Jing He, Yunjie Jin, Ruonan Zhang, Wenjing Dong, Mingen Lin, Yajing Yang, Tongguan Tian, Yuefan Zhou, Yixin Xu, Qun-Ying Lei, Jing Zhang, Qing Zhang, Yanping Xu, Lei Lv

Cancer Res (2022) 82 (11): 2097–2109.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-3013

Published: 06 June 2022

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Includes: Supplementary data

Journal Articles

Suppression of Endothelial Cell FAK Expression Reduces Pancreatic Ductal Adenocarcinoma Metastasis after Gemcitabine Treatment

Cancer Res (2022) 82 (10): 1909–1925.

DOI: https://doi.org/10.1158/0008-5472.CAN-20-3807

Published: 16 May 2022

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Includes: Supplementary data

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RNA Helicase DHX37 Facilitates Liver Cancer Progression by Cooperating with PLRG1 to Drive Superenhancer-Mediated Transcription of Cyclin D1

Zhen Liu, Youqiong Ye, Yizhe Liu, Yanfang Liu, Huifang Chen, Mengting Shen, Zhen Wang, Shenglin Huang, Leng Han, Zhiao Chen, Xianghuo He

Cancer Res (2022) 82 (10): 1937–1952.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-3038

Published: 16 May 2022

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Includes: Supplementary data

Journal Articles

Differential Gain-of-Function Activity of Three p53 Hotspot Mutants In Vivo

Shunbin Xiong, Dhruv Chachad, Yun Zhang, Jovanka Gencel-Augusto, Mario Sirito, Vinod Pant, Peirong Yang, Chang Sun, Gilda Chau, Yuan Qi, Xiaoping Su, Elizabeth M. Whitley, Adel K. El-Naggar, Guillermina Lozano

Cancer Res (2022) 82 (10): 1926–1936.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-3376

Published: 16 May 2022

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Includes: Supplementary data

Journal Articles

Cardiac Dysfunction Promotes Cancer Progression via Multiple Secreted Factors

Lama Awwad, Ami Aronheim

Cancer Res (2022) 82 (9): 1753–1761.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-2463

Published: 03 May 2022

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Includes: Supplementary data

Journal Articles

Genome-Protective Topoisomerase 2a-Dependent G₂ Arrest Requires p53 in hTERT-Positive Cancer Cells

Nicola Lockwood, Silvia Martini, Ainara Lopez-Pardo, Katharina Deiss, Hendrika A. Segeren, Robert K. Semple, Ian Collins, Dimitra Repana, Mathias Cobbaut, Tanya Soliman, Francesca Ciccarelli, Peter J. Parker

Cancer Res (2022) 82 (9): 1762–1773.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-1785

Published: 03 May 2022

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Includes: Supplementary data

Journal Articles

Loss of KMT5C Promotes EGFR Inhibitor Resistance in NSCLC via LINC01510-Mediated Upregulation of MET

Arpita S. Pal, Alejandra Agredo, Nadia A. Lanman, Jihye Son, Ikjot Singh Sohal, Manvir Bains, Chennan Li, Jenna Clingerman, Kayla Gates, Andrea L. Kasinski

Cancer Res (2022) 82 (8): 1534–1547.

DOI: https://doi.org/10.1158/0008-5472.CAN-20-0821

Published: 15 April 2022

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Includes: Supplementary data

Journal Articles

In Vivo Modeling of Patient Genetic Heterogeneity Identifies New Ways to Target Cholangiocarcinoma

Nicholas T. Younger, Mollie L. Wilson, Anabel Martinez Lyons, Edward J. Jarman, Alison M. Meynert, Graeme R. Grimes, Konstantinos Gournopanos, Scott H. Waddell, Peter A. Tennant, David H. Wilson, Rachel V. Guest, Stephen J. Wigmore, Juan Carlos Acosta, Timothy J. Kendall, Martin S. Taylor, Duncan Sproul, Pleasantine Mill, Luke Boulter

Cancer Res (2022) 82 (8): 1548–1559.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-2556

Published: 15 April 2022

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Includes: Supplementary data

Journal Articles

Extracellular Vesicle–Packaged CDH11 and ITGA5 Induce the Premetastatic Niche for Bone Colonization of Breast Cancer Cells

Xiao-Qing Li, Rui Zhang, Hong Lu, Xiao-Min Yue, Yu-Fan Huang

Cancer Res (2022) 82 (8): 1560–1574.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-1331

Published: 15 April 2022

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Includes: Supplementary data

Journal Articles

Autocrine Canonical Wnt Signaling Primes Noncanonical Signaling through ROR1 in Metastatic Castration-Resistant Prostate Cancer

Fen Ma, Seiji Arai, Keshan Wang, Carla Calagua, Amanda R. Yuan, Larysa Poluben, Zhongkai Gu, Joshua W. Russo, David J. Einstein, Huihui Ye, Meng Xiao He, Yu Liu, Eliezer Van Allen, Adam G. Sowalsky, Manoj K. Bhasin, Xin Yuan, Steven P. Balk

Cancer Res (2022) 82 (8): 1518–1533.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-1807

Published: 15 April 2022

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Includes: Supplementary data

Journal Articles

Chaperone-Mediated Autophagy Controls Proteomic and Transcriptomic Pathways to Maintain Glioma Stem Cell Activity

Jaione Auzmendi-Iriarte, Maddalen Otaegi-Ugartemendia, Estefania Carrasco-Garcia, Mikel Azkargorta, Antonio Diaz, Ander Saenz-Antoñanzas, Joaquin Andrés Andermatten, Mikel Garcia-Puga, Idoia Garcia, Alejandro Elua-Pinin, Irune Ruiz, Nicolas Sampron, Felix Elortza, Ana Maria Cuervo, Ander Matheu

Cancer Res (2022) 82 (7): 1283–1297.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-2161

Published: 01 April 2022

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Includes: Supplementary data

Journal Articles

Targeting Squalene Epoxidase Interrupts Homologous Recombination via the ER Stress Response and Promotes Radiotherapy Efficacy

Cancer Res (2022) 82 (7): 1298–1312.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-2229

Published: 01 April 2022

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Includes: Supplementary data

Journal Articles

Alterations of the Mdm2 C-Terminus Differentially Impact Its Function In Vivo

Vinod Pant, Neeraj K. Aryal, Shunbin Xiong, Gilda P. Chau, Natalie W. Fowlkes, Guillermina Lozano

Cancer Res (2022) 82 (7): 1313–1320.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-2381

Published: 01 April 2022

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Journal Articles

Hotspot ESR1 Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis

Cancer Res (2022) 82 (7): 1321–1339.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-2576

Published: 01 April 2022

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Includes: Supplementary data

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NARROW

Autocrine GMCSF Signaling Contributes to Growth of HER2⁺ Breast Leptomeningeal Carcinomatosis

Aberrant Nuclear Export of circNCOR1 Underlies SMAD7-Mediated Lymph Node Metastasis of Bladder Cancer

Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer

Rab13 Sustains Breast Cancer Stem Cells by Supporting Tumor–Stroma Cross-talk

A Genome-Wide CRISPR Activation Screen Identifies PRRX2 as a Regulator of Enzalutamide Resistance in Prostate Cancer

Phosphorylation of SHP2 at Tyr62 Enables Acquired Resistance to SHP2 Allosteric Inhibitors in FLT3-ITD–Driven AML

TET2 Suppresses VHL Deficiency-Driven Clear Cell Renal Cell Carcinoma by Inhibiting HIF Signaling

Suppression of Endothelial Cell FAK Expression Reduces Pancreatic Ductal Adenocarcinoma Metastasis after Gemcitabine Treatment

RNA Helicase DHX37 Facilitates Liver Cancer Progression by Cooperating with PLRG1 to Drive Superenhancer-Mediated Transcription of Cyclin D1

Differential Gain-of-Function Activity of Three p53 Hotspot Mutants In Vivo

Cardiac Dysfunction Promotes Cancer Progression via Multiple Secreted Factors

Genome-Protective Topoisomerase 2a-Dependent G₂ Arrest Requires p53 in hTERT-Positive Cancer Cells

Loss of KMT5C Promotes EGFR Inhibitor Resistance in NSCLC via LINC01510-Mediated Upregulation of MET

In Vivo Modeling of Patient Genetic Heterogeneity Identifies New Ways to Target Cholangiocarcinoma

Extracellular Vesicle–Packaged CDH11 and ITGA5 Induce the Premetastatic Niche for Bone Colonization of Breast Cancer Cells

Autocrine Canonical Wnt Signaling Primes Noncanonical Signaling through ROR1 in Metastatic Castration-Resistant Prostate Cancer

Chaperone-Mediated Autophagy Controls Proteomic and Transcriptomic Pathways to Maintain Glioma Stem Cell Activity

Targeting Squalene Epoxidase Interrupts Homologous Recombination via the ER Stress Response and Promotes Radiotherapy Efficacy

Alterations of the Mdm2 C-Terminus Differentially Impact Its Function In Vivo

Hotspot ESR1 Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis

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