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Journal Articles

Abstract PD14-01: Comprehensive molecular characterization of patients with metastatic invasive lobular carcinoma (ILC): Using real-world data to describe this unique clinical entity

Andrew A Davis, Amir Behdad, Kayla Viets Layng, Firas Wehbe, Lorenzo Gerratana, Elizabeth Mauer, Alex Barrett, Ami N Shah, Paolo D’Amico, Lisa Flaum, William J Gradishar, Leonidas C Platanias, Massimo Cristofanilli
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD14-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-PD14-01
Published: 15 February 2022
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Journal Articles

Abstract PD6-03: Spatio-molecular dissection of the breast cancer metastatic microenvironment

Daniel L Abravanel, Johanna Klughammer, Timothy Blosser, Yury Goltsev, Sizun Jiang, Yunjao Bai, Evan Murray, Shahar Alon, Yi Cui, Daniel R Goodwin, Anubhav Sinha, Ofir Cohen, Michal Slyper, Orr Ashenberg, Danielle Dionne, Judit Jané-Valbuena, Caroline BM Porter, Asa Segerstolpe, Julia Waldman, Sébastien Vigneau, Karla Helvie, Allison Frangieh, Laura DelloStritto, Miraj Patel, Jingyi We, Kathleen Pfaff, Nicole Cullen, Ana Lako, Madison Turner, Isaac Wakiro, Sara Napolitano, Abhay Kanodia, Rebecca Ortiz, Colin MacKichan, Stephanie Inga, Judy Chen, Aaron R Thorner, Asaf Rotem, Scott Rodig, Fei Chen, Edward S Boyden, Garry P Nolan, Xiaowei Zhuang, Orit Rozenblatt-Rosen, Bruce E Johnson, Aviv Regev, Nikhil Wagle
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD6-03.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-PD6-03
Published: 15 February 2022
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Journal Articles

Abstract PD6-02: The metastatic breast cancer project - Expanding the clinical, genomic, and transcriptomic landscape of metastatic breast cancer through patient-partnered research

Esha Jain, Dewey Kim, Jorge Gomez Tejeda Zanudo, Sara Balch, Mary McGillicuddy, Brett N. Tomson, Tania G. Hernandez, Beena S. Thomas, Daniel L. Abravanel, Shahrayz Shah, Rafael Ramos, Delia Sosa, Ilan Small, Lauren Sterlin, Sarah Winnicki, Colleen Nguyen, Micheal Dunphy, Elana Anastasio, Todd R. Golub, Corrie A. Painter, Nikhil Wagle
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD6-02.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-PD6-02
Published: 15 February 2022
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Journal Articles

Abstract PD2-08: Serial genomic profiling reveals molecular mechanisms of breast cancer resistance to palbociclib

Zhengyan Kan, Seock-Ah Im, Kyunghee Park, Ji Wen, Kyung-Hun Lee, Yoon-La Choi, Won-Chul Lee, Ahrum Min, Vinicius Bonato, Seri Park, Sripad Ram, Dae-Won Lee, Ji-Yeon Kim, Su Kyeong Lee, Won-Woo Lee, Jisook Lee, Miso Kim, Scott L. Weinrich, Han Suk Ryu, Tae Yong Kim, Stephen Dann, Diane Fernandez, Jiwon Koh, Song Yi Park, Shibing Deng, Eric Powell, Rupesh Kanchi Ravi, Jadwiga Bienkowska, Paul A. Rejto, Woong-Yang Park, Yeon Hee Park
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD2-08.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-PD2-08
Published: 15 February 2022
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Journal Articles

Abstract PD6-07: Whole genome sequencing-based circulating tumor DNA profiling of metastatic breast cancer patients for molecular characterization and therapy response prediction

Joohyuk Sohn, Min Hwan Kim, Jin Mo Ahn, Won-Ji Ryu, Seul-Gi Kim, Jee Hung Kim, Tae Yeong Kim, Hyun Ju Han, Jee Ye Kim, Hyung Seok Park, Seho Park, Byeong Woo Park, Seung Il Kim, Eun Hae Cho, Gun Min Kim
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD6-07.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-PD6-07
Published: 15 February 2022
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Journal Articles

Abstract PD3-04: Multi-omics characterization of triple-negative breast cancer identifies therapeutic vulnerabilities and epigenetic immune suppression in the mesenchymal subtype

Brian D Lehmann, Antonio Colaprico, Tiago C Silva, Jianjiao Chen, Hanbing An, Yuguang Ban, Lily Wang, Jamaal L James, Justin Balko, Paula I Gonzalez-Ericsson, Melinda E Sanders, Bing Zhang, Jennifer A Pietenpol, Xi S Chen
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD3-04.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-PD3-04
Published: 15 February 2022
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Journal Articles

Abstract P3-09-08: An automated tool to determine optimal cluster numbers in single-cell RNA sequencing data identifies key prognostic subsets of T cells in breast tumors

Siyao Liu, Aatish Thennavan, J.S. Marron, Charles Perou
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-09-08.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P3-09-08
Published: 15 February 2022
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Journal Articles

Abstract P3-09-07: R-loop forming sequences determine early response genes and tumorigenic pathways driven in BRCA1-deficient carriers

Andre Grageda, Vladimir A Kuznetsov
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-09-07.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P3-09-07
Published: 15 February 2022
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Journal Articles

Abstract P3-09-19: The utility of using genomic testing on needle core biopsies during the COVID-19 pandemic: Molecular characterization, risk stratification, neoadjuvant outcome, and future implications

Hani Katerji, Huina Zhang, Xi Wang, Linda Schiffhauer, Ajay Dhakal, Alissa Huston, Carla Falkson, David Hicks, Bradley Turner
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-09-19.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P3-09-19
Published: 15 February 2022
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Journal Articles

Abstract P3-09-06: Targeting tumor subpopulations based on single-cell transcriptomics

Jacqueline M Grible, Tess Leftwich, Amy L Olex, Alex K Duong, Nicole Hairr, Narmeen S Rashid, Timothy M Smith, Lia Signaevskaia, David C Boyd, Mikhail G Dozmorov, Joshua C Harrell
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-09-06.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P3-09-06
Published: 15 February 2022
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Journal Articles

Abstract P3-09-05: Genomic and clinical characterization of breast tumors with unusual HER2 FISH pattern (ratio < 2, HER2 copy number ≥ 6): Are they mostly HER2 “positive?”

Christina H Wei, Lixin Yang, Daphne Stewart, Victoria Bedell, Daniel Schmolze, Sophia Apple, Joyce L. Murata-Collins, Raju Pillai, Joanne E. Mortimer
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-09-05.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P3-09-05
Published: 15 February 2022
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Journal Articles

Abstract P3-09-16: Validating alternative splicing events between bulk and scRNA sequencing data: A bioinformatic approach

Gannon Cottone, Benjamin T Spike, Elnaz Mirzaei Mehrabad, Seema A Khan, Susan Clare
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-09-16.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P3-09-16
Published: 15 February 2022
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Journal Articles

Abstract P3-09-15: Value-added clinical tumor/normal whole exome and whole transcriptome sequencing versus a DNA and RNA tumor only gene panel for managing breast cancer

Kimberly S. Cole, Zhiqiang Li, Amy Tiersten, Wanying Zhang, Hussam Al-Kateb, Feras M. Hantash, Michael R. Rossi, Scott Newman, Xiang Zhou, Eric E. Schadt, Rong Chen, William K. Oh, Marc Y. Fink
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-09-15.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P3-09-15
Published: 15 February 2022
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Journal Articles

Abstract P3-09-14: Whole exome sequencing of matched primary and metastatic triple-negative breast cancer samples

Jaspreet Kaur, Darshan S. Chandrashekar, Zsuzsanna Varga, Emiel Janssen, Khanjan Gandhi, Karuna Mittal, Umay Kiraz, Sooryanarayana Varambally, Ritu Aneja
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-09-14.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P3-09-14
Published: 15 February 2022
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Journal Articles

Abstract P3-09-13: Androgen receptor loss is associated with genomic instability characterized by copy number alterations and mirna deregulation in triple-negative breast cancer

Shristi Bhattarai, Bruna M. Sugita, Luciane Cavalli, Ritu Aneja
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-09-13.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P3-09-13
Published: 15 February 2022
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Journal Articles

Abstract P3-09-04: Genomic landscape of HER2-negative advanced or metastatic breast cancer with PIK3CA gain-of-function mutations

Jing Xi, Kathleen Harnden, Jingqin Luo, Greg S. Call, Elizabeth Mauer, Karyn Ronski, Cynthia X. Ma, Neil Vasan
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-09-04.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P3-09-04
Published: 15 February 2022
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Journal Articles

Abstract P3-09-03: Single nucletotide polymorphisms of aromatase gene (CYP19A1) and toxicity of adjuvant aromatase inhibitors: A translational, prospective study

Benedetta Conte, Chiara Molinelli, Giancarlo Bisagni, Antonio Durando, Giovanni Sanna, Stefania Gori, Ornella Garrone, Stefano Tamberi, Sabino De Placido, Francesco Schettini, Antonio Pazzola, Riccardo Ponzone, Filippo Montemurro, Gianluigi Lunardi, Rosario Notaro, Anna Turletti, Claudia Bighin, Francesca Poggio, Giulia Buzzatti, Matteo Lambertini, Luca Boni, Lucia Del Mastro
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-09-03.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P3-09-03
Published: 15 February 2022
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Journal Articles

Abstract P3-09-02: Mutational assessment of newly diagnosed breast cancer using Germline and tumor genomICs

Dilanka L De Silva, Anita R Skandarajah, Michelle Sinclair, Maira Kentwell, Lisa Devereux, Magnus Zeethoven, Kirsten Hogg, Luxi Lal, Lesley Stafford, Paul A James, Geoffrey J Lindeman, Gregory B Mann, Ian G Campbell
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-09-02.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P3-09-02
Published: 15 February 2022
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Journal Articles

Abstract P3-09-01: A ubiquitination cascade regulating the integrated stress response and survival in carcinomas

Lisa D Cervia, Tsukasa Shibue, Benjamin Gaeta, Ashir A Borah, Lisa Leung, Naomi Li, Nancy Dumont, Alfredo Gonzalez, Nolan Bick, Mariya Kazachkova, Joshua M Dempster, John M Krill-Burger, Federica Piccioni, Namrata D Udeshi, Meagan E Olive, Steven A Carr, David E Root, James M McFarland, Francisca Vazquez, William C Hahn
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-09-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P3-09-01
Published: 15 February 2022
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Journal Articles

Abstract P3-09-12: Breast cancer derived GATA3 mutations disrupt luminal transcriptional network

Motoki Takaku, Mika Saotome, Renju Nair
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-09-12.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P3-09-12
Published: 15 February 2022
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