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Journal Articles

In Vitro Insertional Mutagenesis Screen Identifies Novel Genes Driving Breast Cancer Metastasis

Csaba Miskey, Lacramioara Botezatu, Nuri A. Temiz, Andreas Gogol-Döring, Áron Bartha, Balázs Győrffy, David A. Largaespada, Zoltán Ivics, Attila Sebe

Mol Cancer Res OF1–OF14.

DOI: https://doi.org/10.1158/1541-7786.MCR-21-0772

Published: 23 June 2022

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Includes: Supplementary data

Journal Articles

Loss of E-cadherin Induces IGF1R Activation and Reveals a Targetable Pathway in Invasive Lobular Breast Carcinoma

Ashuvinee Elangovan, Jagmohan Hooda, Laura Savariau, Susrutha Puthanmadhomnarayanan, Megan E. Yates, Jian Chen, Daniel D. Brown, Priscilla F. McAuliffe, Steffi Oesterreich, Jennifer M. Atkinson, Adrian V. Lee

Mol Cancer Res OF1–OF15.

DOI: https://doi.org/10.1158/1541-7786.MCR-22-0090

Published: 23 June 2022

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Includes: Supplementary data

Journal Articles

Dependence on the MUC1-C Oncoprotein in Classic, Variant, and Non–neuroendocrine Small Cell Lung Cancer

Atsushi Fushimi, Yoshihiro Morimoto, Satoshi Ishikawa, Nami Yamashita, Atrayee Bhattacharya, Tatsuaki Daimon, Hasan Rajabi, Caining Jin, Masayuki Hagiwara, Yota Yasumizu, Zhou Luan, Wenhao Suo, Kwok-Kin Wong, Henry Withers, Song Liu, Mark D. Long, Donald Kufe

Mol Cancer Res OF1–OF12.

DOI: https://doi.org/10.1158/1541-7786.MCR-22-0165

Published: 16 June 2022

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Includes: Supplementary data

Journal Articles

Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner

Jinghai Wu, Xin Liu, Julie A. Wallace Reeser, Anthony J. Trimboli, Thierry Pécot, Gina M. Sizemore, Shan K. Naidu, Soledad A. Fernandez, Lianbo Yu, Michael Hallett, Morag Park, Gustavo W. Leone, Blake E. Hildreth, III, Michael C. Ostrowski

Mol Cancer Res OF1–OF14.

DOI: https://doi.org/10.1158/1541-7786.MCR-21-0960

Published: 16 June 2022

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Includes: Supplementary data

Journal Articles

Attenuating Adaptive VEGF-A and IL8 Signaling Restores Durable Tumor Control in AR Antagonist–Treated Prostate Cancers

Pamela J. Maxwell, Melanie McKechnie, Christopher W. Armstrong, Judith M. Manley, Chee Wee Ong, Jenny Worthington, Ian G. Mills, Daniel B. Longley, James P. Quigley, Amina Zoubeidi, Johann S. de Bono, Elena Deryugina, Melissa J. LaBonte, David J.J. Waugh

Mol Cancer Res (2022) 20 (6): 841–853.

DOI: https://doi.org/10.1158/1541-7786.MCR-21-0780

Published: 03 June 2022

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Includes: Supplementary data

Journal Articles

Suppression of SIN3A by miR-183 Promotes Breast Cancer Metastasis

Mackenzie L. Davenport, Mara R. Davis, Baylea N. Davenport, David K. Crossman, Aaron Hall, Jason Pike, Shuko Harada, Douglas R. Hurst, Mick D. Edmonds

Mol Cancer Res (2022) 20 (6): 883–894.

DOI: https://doi.org/10.1158/1541-7786.MCR-21-0508

Published: 03 June 2022

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Journal Articles

Vitamin D Receptor Activation Attenuates Hippo Pathway Effectors and Cell Survival in Metastatic Neuroblastoma

Yagnesh Ladumor, Bo Kyung Alex Seong, Robin Hallett, Ivette Valencia-Sama, Teresa Adderley, Yingying Wang, Lynn Kee, Alexander Gont, David R. Kaplan, Meredith S. Irwin

Mol Cancer Res (2022) 20 (6): 895–908.

DOI: https://doi.org/10.1158/1541-7786.MCR-21-0425

Published: 03 June 2022

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Includes: Supplementary data

Journal Articles

Inhibiting WEE1 and IKK-RELA Crosstalk Overcomes TNFα Resistance in Head and Neck Cancers

Zhengbo Hu, Ramya Viswanathan, Hui Cheng, Jianghong Chen, Xinping Yang, Angel Huynh, Paul Clavijo, Yi An, Yvette Robbins, Christopher Silvin, Clint Allen, Pinar Ormanoglu, Scott Martin, Shaleeka Cornelius, Anthony Saleh, Zhong Chen, Carter Van Waes, Ethan L. Morgan

Mol Cancer Res (2022) 20 (6): 867–882.

DOI: https://doi.org/10.1158/1541-7786.MCR-21-0624

Published: 03 June 2022

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EML4-ALK Variant 3 Promotes Mitotic Errors and Spindle Assembly Checkpoint Deficiency Leading to Increased Microtubule Poison Sensitivity

Kellie Lucken, Laura O'Regan, Jene Choi, Josephina Sampson, Sarah L. Pashley, Richard Bayliss, Sam Khan, Andrew M. Fry

Mol Cancer Res (2022) 20 (6): 854–866.

DOI: https://doi.org/10.1158/1541-7786.MCR-21-1010

Published: 03 June 2022

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Journal Articles

Phosphoproteomics Reveals the Role of Constitutive KAP1 Phosphorylation by B-cell Receptor Signaling in Chronic Lymphocytic Leukemia

Jung-Lin Wu, Hsin-Yi Wu, Shang-Ju Wu, Ho-Yang Tsai, Shao-Hsing Weng, Kuen-Tyng Lin, Liang-In Lin, Chi-Yuan Yao, Margarita Zamanova, Yi-Yuan Lee, Takashi Angata, Hwei-Fang Tien, Yu-Ju Chen, Kuo-I Lin

Mol Cancer Res OF1–OF11.

DOI: https://doi.org/10.1158/1541-7786.MCR-21-0722

Published: 01 June 2022

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Journal Articles

MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion

Saravanakumar Marimuthu, Imayavaramban Lakshmanan, Sakthivel Muniyan, Shailendra K. Gautam, Rama Krishna Nimmakayala, Sanchita Rauth, Pranita Atri, Ashu Shah, Namita Bhyravbhatla, Kavita Mallya, Paul M. Grandgenett, Michael A. Hollingsworth, Kaustubh Datta, Maneesh Jain, Moorthy P. Ponnusamy, Surinder K. Batra

Mol Cancer Res OF1–OF14.

DOI: https://doi.org/10.1158/1541-7786.MCR-21-0888

Published: 01 June 2022

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Includes: Supplementary data

Journal Articles

TGF-β-Induced FLRT3 Attenuation Is Essential for Cancer-Associated Fibroblast–Mediated Epithelial–Mesenchymal Transition in Colorectal Cancer

Mengdi Yang, Dan Li, Zhiyuan Jiang, Changcan Li, Suyuan Ji, Jing Sun, Yujie Chang, Shunyi Ruan, Zhiyu Wang, Rui Liang, Xueyu Dai, Bin Li, Hui Zhao

Mol Cancer Res OF1–OF13.

DOI: https://doi.org/10.1158/1541-7786.MCR-21-0924

Published: 01 June 2022

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Journal Articles

Combinatorial Treatment with PARP-1 Inhibitors and Cisplatin Attenuates Cervical Cancer Growth through Fos-Driven Changes in Gene Expression

Rebecca Gupte, Ken Y. Lin, Tulip Nandu, Jayanthi S. Lea, W. Lee Kraus

Mol Cancer Res OF1–OF10.

DOI: https://doi.org/10.1158/1541-7786.MCR-22-0111

Published: 25 May 2022

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Journal Articles

Loss of PBRM1 Alters Promoter Histone Modifications and Activates ALDH1A1 to Drive Renal Cell Carcinoma

David A. Schoenfeld, Royce Zhou, Sakellarios Zairis, William Su, Nicole Steinbach, Deepti Mathur, Ankita Bansal, Alexis L. Zachem, Bertilia Tavarez, Dan Hasson, Emily Bernstein, Raul Rabadan, Ramon Parsons

Mol Cancer Res OF1–OF15.

DOI: https://doi.org/10.1158/1541-7786.MCR-21-1039

Published: 11 May 2022

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Includes: Supplementary data

Journal Articles

HIPK2 Cooperates with KRAS Signaling and Associates with Colorectal Cancer Progression

Micol Di Segni, Ilaria Virdia, Alessandra Verdina, Carla Azzurra Amoreo, Silvia Baldari, Gabriele Toietta, Maria Grazia Diodoro, Marcella Mottolese, Isabella Sperduti, Fabiola Moretti, Simonetta Buglioni, Silvia Soddu, Giuliana Di Rocco

Mol Cancer Res (2022) 20 (5): 686–698.

DOI: https://doi.org/10.1158/1541-7786.MCR-21-0628

Published: 04 May 2022

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Journal Articles

PARK2 Regulates eIF4B-Driven Lymphomagenesis

Bandish B. Kapadia, Anirban Roychowdhury, Forum Kayastha, Nahid Nanaji, Ronald B. Gartenhaus

Mol Cancer Res (2022) 20 (5): 735–748.

DOI: https://doi.org/10.1158/1541-7786.MCR-21-0729

Published: 04 May 2022

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Includes: Supplementary data

Journal Articles

Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling

Eleonora Sementino, Yuwaraj Kadariya, Mitchell Cheung, Craig W. Menges, Yinfei Tan, Anna-Mariya Kukuyan, Ujjawal Shrestha, Sofiia Karchugina, Kathy Q. Cai, Suraj Peri, James S. Duncan, Jonathan Chernoff, Joseph R. Testa

Mol Cancer Res (2022) 20 (5): 699–711.

DOI: https://doi.org/10.1158/1541-7786.MCR-21-0837

Published: 04 May 2022

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Includes: Supplementary data

Journal Articles

MYC Promotes Tyrosine Kinase Inhibitor Resistance in ROS1-Fusion-Positive Lung Cancer

Sudarshan R. Iyer, Igor Odintsov, Adam J. Schoenfeld, Evan Siau, Marissa S. Mattar, Elisa de Stanchina, Inna Khodos, Alexander Drilon, Gregory J. Riely, Marc Ladanyi, Romel Somwar, Monika A. Davare

Mol Cancer Res (2022) 20 (5): 722–734.

DOI: https://doi.org/10.1158/1541-7786.MCR-22-0025

Published: 04 May 2022

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Includes: Supplementary data

Journal Articles

Blocking PI3K p110β Attenuates Development of PTEN-Deficient Castration-Resistant Prostate Cancer

Mol Cancer Res (2022) 20 (5): 673–685.

DOI: https://doi.org/10.1158/1541-7786.MCR-21-0322

Published: 04 May 2022

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Includes: Supplementary data

Journal Articles

Inhibition of LSD1 Attenuates Oral Cancer Development and Promotes Therapeutic Efficacy of Immune Checkpoint Blockade and YAP/TAZ Inhibition

Thabet Alhousami, Michael Diny, Faiza Ali, Jennifer Shin, Gaurav Kumar, Vikas Kumar, Joshua D. Campbell, Vikki Noonan, Glenn J. Hanna, Gerald V. Denis, Stefano Monti, Maria A. Kukuruzinska, Xaralabos Varelas, Manish V. Bais

Mol Cancer Res (2022) 20 (5): 712–721.

DOI: https://doi.org/10.1158/1541-7786.MCR-21-0310

Published: 04 May 2022

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Includes: Supplementary data

2 3 4 5

NARROW

In Vitro Insertional Mutagenesis Screen Identifies Novel Genes Driving Breast Cancer Metastasis

Loss of E-cadherin Induces IGF1R Activation and Reveals a Targetable Pathway in Invasive Lobular Breast Carcinoma

Dependence on the MUC1-C Oncoprotein in Classic, Variant, and Non–neuroendocrine Small Cell Lung Cancer

Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner

Attenuating Adaptive VEGF-A and IL8 Signaling Restores Durable Tumor Control in AR Antagonist–Treated Prostate Cancers

Suppression of SIN3A by miR-183 Promotes Breast Cancer Metastasis

Vitamin D Receptor Activation Attenuates Hippo Pathway Effectors and Cell Survival in Metastatic Neuroblastoma

Inhibiting WEE1 and IKK-RELA Crosstalk Overcomes TNFα Resistance in Head and Neck Cancers

EML4-ALK Variant 3 Promotes Mitotic Errors and Spindle Assembly Checkpoint Deficiency Leading to Increased Microtubule Poison Sensitivity

Phosphoproteomics Reveals the Role of Constitutive KAP1 Phosphorylation by B-cell Receptor Signaling in Chronic Lymphocytic Leukemia

MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion

TGF-β-Induced FLRT3 Attenuation Is Essential for Cancer-Associated Fibroblast–Mediated Epithelial–Mesenchymal Transition in Colorectal Cancer

Combinatorial Treatment with PARP-1 Inhibitors and Cisplatin Attenuates Cervical Cancer Growth through Fos-Driven Changes in Gene Expression

Loss of PBRM1 Alters Promoter Histone Modifications and Activates ALDH1A1 to Drive Renal Cell Carcinoma

HIPK2 Cooperates with KRAS Signaling and Associates with Colorectal Cancer Progression

PARK2 Regulates eIF4B-Driven Lymphomagenesis

Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling

MYC Promotes Tyrosine Kinase Inhibitor Resistance in ROS1-Fusion-Positive Lung Cancer

Blocking PI3K p110β Attenuates Development of PTEN-Deficient Castration-Resistant Prostate Cancer

Inhibition of LSD1 Attenuates Oral Cancer Development and Promotes Therapeutic Efficacy of Immune Checkpoint Blockade and YAP/TAZ Inhibition

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