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Journal Articles

Loss of E-cadherin Induces IGF1R Activation and Reveals a Targetable Pathway in Invasive Lobular Breast Carcinoma

Ashuvinee Elangovan, Jagmohan Hooda, Laura Savariau, Susrutha Puthanmadhomnarayanan, Megan E. Yates, Jian Chen, Daniel D. Brown, Priscilla F. McAuliffe, Steffi Oesterreich, Jennifer M. Atkinson, Adrian V. Lee
Journal: Molecular Cancer Research
Mol Cancer Res OF1–OF15.
DOI: https://doi.org/10.1158/1541-7786.MCR-22-0090
Published: 23 June 2022
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Includes: Supplementary data
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Abstract 6230: Loss of ALK4 function promotes cancer progression by regulating cell surface TGF-β receptor stability

Manqi Zhang, Jian Chen, Gerard Conrad Blobe
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6230.
DOI: https://doi.org/10.1158/1538-7445.AM2022-6230
Published: 15 June 2022
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Hotspot ESR1 Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis

Zheqi Li, Yang Wu, Megan E. Yates, Nilgun Tasdemir, Amir Bahreini, Jian Chen, Kevin M. Levine, Nolan M. Priedigkeit, Azadeh Nasrazadani, Simak Ali, Laki Buluwela, Spencer Arnesen, Jason Gertz, Jennifer K. Richer, Benjamin Troness, Dorraya El-Ashry, Qiang Zhang, Lorenzo Gerratana, Youbin Zhang, Massimo Cristofanilli, Maritza A. Montanez, Prithu Sundd, Callen T. Wallace, Simon C. Watkins, Caterina Fumagalli, Elena Guerini-Rocco, Li Zhu, George C. Tseng, Nikhil Wagle, Jason S. Carroll, Paul Jank, Carsten Denkert, Maria M. Karsten, Jens-Uwe Blohmer, Ben H. Park, Peter C. Lucas, Jennifer M. Atkinson, Adrian V. Lee, Steffi Oesterreich
Journal: Cancer Research
Cancer Res (2022) 82 (7): 1321–1339.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-2576
Published: 01 April 2022
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A Dual PI3K/HDAC Inhibitor Induces Immunogenic Ferroptosis to Potentiate Cancer Immune Checkpoint Therapy

Fushun Fan, Pei Liu, Rudi Bao, Jian Chen, Minhua Zhou, Zhenxian Mo, Yaru Ma, Haiqi Liu, Yiping Zhou, Xiong Cai, Changgeng Qian, Xinjian Liu
Journal: Cancer Research
Cancer Res (2021) 81 (24): 6233–6245.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-1547
Published: 15 December 2021
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Includes: Supplementary data
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Abstract 2848: Neomorphic cell-cell adhesion reprogramming facilitates metastasis of ESR1 mutant breast cancer

Yang Wu, Zheqi Li, Amir Bahreini, Jian Chen, Ye Qin, Kevin M. Levine, Nilgun Tasdemir, Nolan M. Priedigkeit, Li Zhu, George C. Tseng, Yu Jiang, Benjamin Troness, Laki Buluwela, Simak Ali, Spencer Arnesen, Jason Gertz, Ben Ho Park, Jennifer M. Atkinson, Dorraya El-Ashry, Adrian V. Lee, Steffi Oesterreich
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2848.
DOI: https://doi.org/10.1158/1538-7445.AM2021-2848
Published: 01 July 2021
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Abstract GS1-05: Hotspot ESR1 mutations rewire cell-cell adhesome to facilitate breast cancer metastasis

Zheqi Li, Yang Wu, Amir Bahreini, Jian Chen, Ye Qin, Kevin M. Levine, Nilgun Tasdemir, Nolan Priedigkeit, Li Zhu, George C. Tseng, Yu Jiang, Benjamin Troness, Laki Buluwela, Simak Ali, Spencer Arnesen, Jason Gertz, Ben H. Park, Qiang Zhang, Lorenzo Gerratana, Andrew Davis, Jennifer M. Atkinson, Dorraya El-Ashry, Massimo Cristofanilli, Adrian V. Lee, Steffi Oesterreich
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): GS1-05.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-GS1-05
Published: 15 February 2021
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Journal Articles

Abstract PS17-23: Development of a breast cancer organoid resource faithfully representing epithelial heterogeneity and drug response

Daniel D Brown, Kai Ding, Fangyuan Chen, Jian Chen, Brian Orr, Sarah Taylor, Kurt Weiss, Steffi Oesterreich, Peter C Lucas, Priscilla F McAuliffe, Jennifer M Atkinson, Adrian V Lee
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS17-23.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-PS17-23
Published: 15 February 2021
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Abstract 3054: Targeting TGF-β signaling for obesity/insulin resistance-associated hepatocellular carcinoma

Jian Chen, Xiaoping Su, Andres Rojas, Robert S Bresalier, John R. Stroehlein, Sai-ching Yeung
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3054.
DOI: https://doi.org/10.1158/1538-7445.AM2020-3054
Published: 15 August 2020
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Journal Articles

Abstract 4286: TGF-β signature is a therapeutic biomarker for combination immunotherapy for hepatocellular carcinoma

Jian Chen, Xiaoping Su
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4286.
DOI: https://doi.org/10.1158/1538-7445.AM2020-4286
Published: 15 August 2020
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Journal Articles

Abstract 4064: Optimization of the transposon expression system for electroporation based gene delivery

Jian Chen, Youbang Chen
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4064.
DOI: https://doi.org/10.1158/1538-7445.AM2020-4064
Published: 15 August 2020
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Journal Articles

Abstract 4917: Estrogen receptor D538G mutation promotes cell migration via hyperactivation of Wnt signaling pathway

Zheqi Li, Kevin M. Levine, Spencer Arneson, Kristofer C. Berrett, Nolan M. Priedigkeit, Amir Bahreini, Jian Chen, Li Zhu, Jason S. Carroll, George C. Tseng, Peter C. Lucas, Jennifer M. Atkinson, Jason Gertz, Adrian V. Lee, Steffi Oesterreich
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4917.
DOI: https://doi.org/10.1158/1538-7445.AM2020-4917
Published: 15 August 2020
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Journal Articles

Verteporfin Inhibits PD-L1 through Autophagy and the STAT1–IRF1–TRIM28 Signaling Axis, Exerting Antitumor Efficacy

Jiyong Liang, Lulu Wang, Chao Wang, Jianfeng Shen, Bojin Su, Anantha L. Marisetty, Dexing Fang, Cynthia Kassab, Kang Jin Jeong, Wei Zhao, Yiling Lu, Abhinav K. Jain, Zhicheng Zhou, Han Liang, Shao-Cong Sun, Changming Lu, Zhi-Xiang Xu, Qinghua Yu, Shan Shao, XiaoHua Chen, Meng Gao, Francois X. Claret, Zhiyong Ding, Jian Chen, Pingsheng Chen, Michelle C. Barton, Guang Peng, Gordon B. Mills, Amy B. Heimberger
Journal: Cancer Immunology Research
Series: Author Choice
Cancer Immunol Res (2020) 8 (7): 952–965.
DOI: https://doi.org/10.1158/2326-6066.CIR-19-0159
Published: 01 July 2020
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Includes: Supplementary data
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Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling

Jian Chen, Abhisek Mitra, Shulin Li, Shumei Song, Bao-Ngoc Nguyen, Jiun-Sheng Chen, Ji-Hyun Shin, Nancy R. Gough, Paul Lin, Vincent Obias, Aiwu Ruth He, Zhixing Yao, Tathiane M. Malta, Houtan Noushmehr, Patricia S. Latham, Xiaoping Su, Asif Rashid, Bibhuti Mishra, Ray-Chang Wu, Lopa Mishra
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (9): 1819–1832.
DOI: https://doi.org/10.1158/0008-5472.CAN-19-3116
Published: 04 May 2020
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Includes: Supplementary data
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Abstract A44: High-efficiency electroporation of nonexpanded T cells and NK cells for CAR-T and CAR-NK

Jian Chen, Xiaofeng Xia
Journal: Cancer Immunology Research
Cancer Immunol Res (2020) 8 (4_Supplement): A44.
DOI: https://doi.org/10.1158/2326-6074.TUMIMM18-A44
Published: 01 April 2020
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Abstract P1-21-03: Unique estrogen receptor alpha turnover, regulation and targeting in invasive lobular breast carcinoma

Jennifer M Atkinson, Sreeja Sreekumar, Kevin M Levine, Matthew J Sikora, Jian Chen, David J Dabbs, Carolin Meier, Ahmed Basudan, Nilgun Tasdemir, David Boone, Priscilla F McAuliffe, Rachel C Jankowitz, Adrian V Lee, Steffi Oesterreich
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P1-21-03.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-P1-21-03
Published: 15 February 2020
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Abstract 3382: A pan-cancer analysis reveals high frequency genetic alterations in mediators of signaling by the TGF-β superfamily

Kazufumi Ohshiro, Sobia Zaidi, Anil Korkut, Jian Chen, Shuyun Rao, Shoujun Gu, Wilma Jogunoori, Bibhuti Mishra, Rehan Akbani, Lopa Mishra
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3382.
DOI: https://doi.org/10.1158/1538-7445.AM2019-3382
Published: 01 July 2019
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Abstract 4443: Targeting E3 ligase PJA1 via TGF-β pathway in hepatocellular carcinoma

Kazufumi Ohshiro, Jian Chen, Wilma Jogunoori, Chu-Xia Deng, Bibhuti Mishra, Shulin Li, Lopa Mishra
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4443.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4443
Published: 01 July 2019
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Abstract A026: Novel electroporation method for quick CAR-T-cell manufacture

Jian Chen, Xiaofeng Xia
Journal: Cancer Immunology Research
Cancer Immunol Res (2019) 7 (2_Supplement): A026.
DOI: https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-A026
Published: 01 February 2019
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Abstract 3413: A pan-cancer atlas of genomic, epigenomic and transcriptomic alterations in the TGF-β pathway

Anil Korkut, Sobia Zaidi, Rupa Kanchi, Ashton C. Berger, Gordon Robertson, Lawrence N. Kwong, Mike Datto, Jason Roszik, Shiyun Ling, Andre Schultz, Visweswaran Ravikumar, Ganiraju Manyam, Arvind Rao, Simon Shelley, Yuexin Liu, Zhenlin Ju, Donna Hansel, Guillermo de Velasco, Arjun Pennathur, Jesper B. Andersen, Colm J. O'Rourke, Kazufumi Ohshiro, Wilma Jogunoori, Nancy Gough, Shulin Li, Hatice Osmanbeyoglu, Andres Houseman, Shuyun Rao, Maciej Wiznerowicz, Jian Chen, Shoujun Gu, Wencai Ma, Jiexin Zhang, Pan Tong, Andrew D. Cherniack, Chuxia Deng, Linda Resar-Smith, Jaffer Ajani, The Cancer Genome Atlas Research Network, John N. Weinstein, Lopa Mishra, Rehan Akbani
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3413.
DOI: https://doi.org/10.1158/1538-7445.AM2018-3413
Published: 01 July 2018
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Abstract 2226: TGF-β and CEACAMs regulated biomarkers detect early colorectal cancer

Sobia Zaidi, Anil Korkut, Wilma Jogunoori, Jian Chen, Shoujun Gu, Shuyun Rao, Kazufumi Ohshiro, Rehan Akbani, Chuxia Deng, Bibhuti Mishra, Lopa Mishra
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2226.
DOI: https://doi.org/10.1158/1538-7445.AM2018-2226
Published: 01 July 2018
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