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Journal Articles

Anti-extra domain B splice variant of fibronectin antibody drug conjugate eliminates tumors with enhanced efficacy when combined with checkpoint blockade

Mol Cancer Ther mct.22.0099.

DOI: https://doi.org/10.1158/1535-7163.MCT-22-0099

Published: 06 July 2022

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Includes: Supplementary data

Journal Articles

Abstract LB535: A novel IL12-based immunocytokine targeting fibroblast activation protein (FAP) for the treatment of cancer

Lisa Nadal, Frederik Peissert, Abdullah Elsayed, Chiara Libbra, Dario Neri, Roberto De Luca

Cancer Res (2022) 82 (12_Supplement): LB535.

DOI: https://doi.org/10.1158/1538-7445.AM2022-LB535

Published: 15 June 2022

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Journal Articles

Abstract LB527: A novel dimeric small molecule-radio conjugate targeting fibroblast activation protein with high and prolonged tumor uptake

Samuele Cazzamalli, Andrea Galbiati, Aureliano Zana, Matilde Bocci, Jacopo Millul, Jacqueline Mock, Abdullah Elsayed, Dario Neri

Cancer Res (2022) 82 (12_Supplement): LB527.

DOI: https://doi.org/10.1158/1538-7445.AM2022-LB527

Published: 15 June 2022

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Journal Articles

Abstract LB522: Fibroblast activation protein triggers the release of drug payload from non-internalizing small molecule-drug conjugates in solid tumors

Aureliano Zana, Andrea Galbiati, Ettore Gilardoni, Jacopo Millul, Theo Sturm, Riccardo Stucchi, Matilde Bocci, Abdullah Elsayed, Lisa Nadal, Martina Cirillo, Dario Neri, Samuele Cazzamalli

Cancer Res (2022) 82 (12_Supplement): LB522.

DOI: https://doi.org/10.1158/1538-7445.AM2022-LB522

Published: 15 June 2022

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Journal Articles

A Novel Antibody–IL15 Fusion Protein Selectively Localizes to Tumors, Synergizes with TNF-based Immunocytokine, and Inhibits Metastasis

Riccardo Corbellari, Marco Stringhini, Jaqueline Mock, Tiziano Ongaro, Alessandra Villa, Dario Neri, Roberto De Luca

Mol Cancer Ther (2021) 20 (5): 859–871.

DOI: https://doi.org/10.1158/1535-7163.MCT-20-0853

Published: 01 May 2021

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Includes: Supplementary data

Journal Articles

Immunotherapy with Immunocytokines and PD-1 Blockade Enhances the Anticancer Activity of Small Molecule-Drug Conjugates Targeting Carbonic Anhydrase IX

Jacopo Millul, Christiane Krudewig, Aureliano Zana, Sheila Dakhel Plaza, Emanuele Puca, Alessandra Villa, Dario Neri, Samuele Cazzamalli

Mol Cancer Ther (2021) 20 (3): 512–522.

DOI: https://doi.org/10.1158/1535-7163.MCT-20-0361

Published: 02 March 2021

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Includes: Supplementary data

Journal Articles

An Antibody-Tumor Necrosis Factor Fusion Protein that Synergizes with Oxaliplatin for Treatment of Colorectal Cancer

Davor Bajic, Kerry Chester, Dario Neri

Mol Cancer Ther (2020) 19 (12): 2554–2563.

DOI: https://doi.org/10.1158/1535-7163.MCT-19-0729

Published: 02 December 2020

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Includes: Supplementary data

Journal Articles

Antibody-Based Delivery of Cytokine Payloads to Carbonic Anhydrase IX Leads to Cancer Cures in Immunocompetent Tumor-Bearing Mice

Barbara Ziffels, Marco Stringhini, Philipp Probst, Tim Fugmann, Theo Sturm, Dario Neri

Mol Cancer Ther (2019) 18 (9): 1544–1554.

DOI: https://doi.org/10.1158/1535-7163.MCT-18-1301

Published: 03 September 2019

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Includes: Supplementary data

Journal Articles

Targeted Delivery of IL2 to the Tumor Stroma Potentiates the Action of Immune Checkpoint Inhibitors by Preferential Activation of NK and CD8⁺ T Cells

Cornelia Hutmacher, Nicolás Gonzalo Núñez, Anna Rita Liuzzi, Burkhard Becher, Dario Neri

Cancer Immunol Res (2019) 7 (4): 572–583.

DOI: https://doi.org/10.1158/2326-6066.CIR-18-0566

Published: 01 April 2019

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Includes: Supplementary data

Journal Articles

Antibody–Cytokine Fusions: Versatile Products for the Modulation of Anticancer Immunity

Dario Neri

Cancer Immunol Res (2019) 7 (3): 348–354.

DOI: https://doi.org/10.1158/2326-6066.CIR-18-0622

Published: 01 March 2019

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Journal Articles

Antibody-based Delivery of TNF to the Tumor Neovasculature Potentiates the Therapeutic Activity of a Peptide Anticancer Vaccine

Philipp Probst, Marco Stringhini, Danilo Ritz, Tim Fugmann, Dario Neri

Clin Cancer Res (2019) 25 (2): 698–709.

DOI: https://doi.org/10.1158/1078-0432.CCR-18-1728

Published: 15 January 2019

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Includes: Supplementary data

Journal Articles

Enhanced Therapeutic Activity of Non-Internalizing Small-Molecule-Drug Conjugates Targeting Carbonic Anhydrase IX in Combination with Targeted Interleukin-2

Samuele Cazzamalli, Barbara Ziffels, Fontaine Widmayer, Patrizia Murer, Giovanni Pellegrini, Francesca Pretto, Sarah Wulhfard, Dario Neri

Clin Cancer Res (2018) 24 (15): 3656–3667.

DOI: https://doi.org/10.1158/1078-0432.CCR-17-3457

Published: 31 July 2018

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Includes: Supplementary data

Journal Articles

Abstract 2785: Potency-matched dual cytokine antibody fusion proteins in combination with PD-L1 blockade

Roberto De Luca, Dario Neri

Cancer Res (2018) 78 (13_Supplement): 2785.

DOI: https://doi.org/10.1158/1538-7445.AM2018-2785

Published: 01 July 2018

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Journal Articles

Abstract 2768: Potentiating the action of antibody-dependent cell-mediated cytotoxicity with immunocytokines

Patrizia Murer, Jonathan D. Kiefer, Louis Plüss, Dario Neri

Cancer Res (2018) 78 (13_Supplement): 2768.

DOI: https://doi.org/10.1158/1538-7445.AM2018-2768

Published: 01 July 2018

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Journal Articles

Abstract 3811: Targeted Interleukin 2 and synergy with immune check-point inhibitors

Cornelia Deborah Hutmacher-Berndt, Dario Neri

Cancer Res (2018) 78 (13_Supplement): 3811.

DOI: https://doi.org/10.1158/1538-7445.AM2018-3811

Published: 01 July 2018

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Journal Articles

Abstract 758: Head-to-head comparison of ADC and SMDC products, alone and in combination with antibody-IL2 fusion proteins

Samuele Cazzamalli, Alberto Dal Corso, Fontaine Widmayer, Dario Neri

Cancer Res (2018) 78 (13_Supplement): 758.

DOI: https://doi.org/10.1158/1538-7445.AM2018-758

Published: 01 July 2018

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Journal Articles

Abstract 5563: Kinetically-controlled release of blocking molecules for the targeted enhancement of therapeutic activity in antibody-cytokine fusion proteins

Tiziano Ongaro, Martina Bigatti, Filippo Sladojevich, Etienne Donckele, Alessandra Micaela Villa, Dario Neri

Cancer Res (2018) 78 (13_Supplement): 5563.

DOI: https://doi.org/10.1158/1538-7445.AM2018-5563

Published: 01 July 2018

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Journal Articles

Abstract 5553: A novel immunocytokine for the treatment of cancer

Mattia Matasci, Emanuele Puca, Tiziano Ongaro, Sarah Wulhfard, Alessandra Villa, Dario Neri

Cancer Res (2018) 78 (13_Supplement): 5553.

DOI: https://doi.org/10.1158/1538-7445.AM2018-5553

Published: 01 July 2018

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Journal Articles

Potency-matched Dual Cytokine–Antibody Fusion Proteins for Cancer Therapy

Roberto De Luca, Alex Soltermann, Francesca Pretto, Catherine Pemberton-Ross, Giovanni Pellegrini, Sarah Wulhfard, Dario Neri

Mol Cancer Ther (2017) 16 (11): 2442–2451.

DOI: https://doi.org/10.1158/1535-7163.MCT-17-0211

Published: 01 November 2017

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Includes: Supplementary data

Journal Articles

Sarcoma Eradication by Doxorubicin and Targeted TNF Relies upon CD8⁺ T-cell Recognition of a Retroviral Antigen

Philipp Probst, Janine Kopp, Annette Oxenius, Mario P. Colombo, Danilo Ritz, Tim Fugmann, Dario Neri

Cancer Res (2017) 77 (13): 3644–3654.

DOI: https://doi.org/10.1158/0008-5472.CAN-16-2946

Published: 02 July 2017

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Includes: Supplementary data

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NARROW

Anti-extra domain B splice variant of fibronectin antibody drug conjugate eliminates tumors with enhanced efficacy when combined with checkpoint blockade

Abstract LB535: A novel IL12-based immunocytokine targeting fibroblast activation protein (FAP) for the treatment of cancer

Abstract LB527: A novel dimeric small molecule-radio conjugate targeting fibroblast activation protein with high and prolonged tumor uptake

Abstract LB522: Fibroblast activation protein triggers the release of drug payload from non-internalizing small molecule-drug conjugates in solid tumors

A Novel Antibody–IL15 Fusion Protein Selectively Localizes to Tumors, Synergizes with TNF-based Immunocytokine, and Inhibits Metastasis

Immunotherapy with Immunocytokines and PD-1 Blockade Enhances the Anticancer Activity of Small Molecule-Drug Conjugates Targeting Carbonic Anhydrase IX

An Antibody-Tumor Necrosis Factor Fusion Protein that Synergizes with Oxaliplatin for Treatment of Colorectal Cancer

Antibody-Based Delivery of Cytokine Payloads to Carbonic Anhydrase IX Leads to Cancer Cures in Immunocompetent Tumor-Bearing Mice

Targeted Delivery of IL2 to the Tumor Stroma Potentiates the Action of Immune Checkpoint Inhibitors by Preferential Activation of NK and CD8⁺ T Cells

Antibody–Cytokine Fusions: Versatile Products for the Modulation of Anticancer Immunity

Antibody-based Delivery of TNF to the Tumor Neovasculature Potentiates the Therapeutic Activity of a Peptide Anticancer Vaccine

Enhanced Therapeutic Activity of Non-Internalizing Small-Molecule-Drug Conjugates Targeting Carbonic Anhydrase IX in Combination with Targeted Interleukin-2

Abstract 2785: Potency-matched dual cytokine antibody fusion proteins in combination with PD-L1 blockade

Abstract 2768: Potentiating the action of antibody-dependent cell-mediated cytotoxicity with immunocytokines

Abstract 3811: Targeted Interleukin 2 and synergy with immune check-point inhibitors

Abstract 758: Head-to-head comparison of ADC and SMDC products, alone and in combination with antibody-IL2 fusion proteins

Abstract 5563: Kinetically-controlled release of blocking molecules for the targeted enhancement of therapeutic activity in antibody-cytokine fusion proteins

Abstract 5553: A novel immunocytokine for the treatment of cancer

Potency-matched Dual Cytokine–Antibody Fusion Proteins for Cancer Therapy

Sarcoma Eradication by Doxorubicin and Targeted TNF Relies upon CD8⁺ T-cell Recognition of a Retroviral Antigen

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